Supplemental zinc and bone turnover in early pubertal females

青春期早期女性补充锌和骨转换

• 批准号: 7185375
• 负责人: RICHARD D LEWIS
• 金额: $ 7.38万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-20 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7185375
• 关键词: Adolescence; Adolescent; Adult; Age; Age-Years; Alkaline Phosphatase; Animals; Biochemical; Biochemical Markers; Bone Density; Bone Mineral Contents; Calcium; Ceruloplasmin; Child; Childhood; Clinical; Condition; Control Groups; Copper; Data; Depressed mood; Diet; Dietary intake; End Point; Energy Intake; Erythrocytes; Failure to Thrive; Fatty acid glycerol esters; Female; Female Adolescents; Forearm; Growth; Growth Factor; Health; Hip region structure; Impairment; Infant; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Intake; Intervention Studies; Intervention Trial; Iron; Measures; Mediating; Metabolism; Minerals; Not Hispanic or Latino; Nutrient; Osteocalcin; Osteogenesis; Osteoporosis; Participant; Phase; Physical activity; Physiologic calcification; Placebos; Plasma; Postmenopause; Premenopause; Primates; Property; Proteins; Race; Randomized; Randomized Controlled Trials; Rate; Rattus; Reporting; Research; Risk; Role; Serum Markers; Sexual Maturation; Site; Skeletal system; Skeleton; Sodium; Somatotropin; Stimulus; Superoxide Dismutase; Supplementation; Testing; Therapeutic; Time; Trace metal; Upper arm; Vertebral Bone; Vertebral column; Vitamin A; Vitamin D; Week; Woman; Zinc; Zinc Sulfate; Zinc deficiency; base; bone; bone health; bone metabolism; bone strength; bone turnover; day; deoxypyridinoline; double-blind placebo controlled trial; gluconate; human study; improved; indexing; interest; men; nutrition; prospective; racial difference; rapid growth; response

DESCRIPTION (provided by applicant): Significant accomplishments have been achieved with respect to our understanding of calcium and vitamin D and skeletal health, yet a body of scientific evidence has also identified understudied nutrients that have potential for reducing the burden of osteoporosis. Zinc has important roles in bone metabolism and there are indications from animal and human studies that beyond correcting skeletal and growth impairments under deficiency conditions, supplementation with zinc may have a bone health-promoting role. It has been postulated that the action of zinc on bone metabolism is partially mediated by IGF-I. Prior to undertaking a long-term bone trial, a short-term zinc supplementation trial is proposed to first determine if zinc alters intermediate markers of bone metabolism in healthy, early pubertal females (9-10.5 years of age). We hypothesize that healthy females receiving 24 mg zinc /day over 3 weeks will have elevated serum markers of bone formation and plasma growth factors compared to those receiving placebo. We further hypothesize that the differences between the zinc and placebo groups will vary by race. To test these hypotheses, we will screen early pubertal females to assure similar maturational status and conduct a 3-week, randomized, double-blind, placebo-controlled trial with a zinc supplementation (zinc sulfate; n=80) and a placebo (n=80) arm. The groups will be further divided by race (non-Hispanic White and non-Hispanic Black; n=40 per group). The specific aims are to determine if early pubertal females supplemented with zinc compared to those receiving placebo will have: 1) greater increases in markers of bone turnover favoring bone formation; 2) greater increases in plasma IGF-1 and IGFBP-3; and 3) changes in bone turnover markers, IGF-1 and IGFBP-3 that differ by race. In addition, anthropometric measures, maturity offset, sexual maturation, erythrocyte superoxide dismutase activity, ceruloplasmin, dietary intakes and physical activity will be determined. Findings from this study will provide preliminary evidence of whether supplementation with zinc is a viable nutrition strategy to improve biochemical indices of bone turnover and growth factors in young females. Moreover, the results will help determine if a long-term clinical bone trial is warranted to more definitely assess the potential for supplemental zinc to reduce the risk for osteoporosis.

描述（由申请人提供）：在我们对钙和维生素D以及骨骼健康的理解方面已经取得了重大成就，但大量科学证据也确定了有可能减轻骨质疏松症负担的未充分研究的营养素。锌在骨代谢中具有重要作用，动物和人类研究表明，除了在缺乏条件下纠正骨骼和生长障碍外，补充锌可能具有促进骨骼健康的作用。据推测，锌对骨代谢的作用部分由IGF-I介导。在进行长期骨试验之前，建议进行短期锌补充试验，以首先确定锌是否改变健康青春期早期女性（9-10.5岁）骨代谢的中间标志物。我们假设，与接受安慰剂的健康女性相比，接受24 mg锌/天超过3周的健康女性的骨形成和血浆生长因子的血清标志物升高。我们进一步假设，锌和安慰剂组之间的差异将因种族而异。为了验证这些假设，我们将筛选青春期早期女性，以确保相似的成熟状态，并进行为期3周的随机、双盲、安慰剂对照试验，其中包括补锌（硫酸锌; n=80）和安慰剂（n=80）组。将按种族进一步分组（非西班牙裔白色和非西班牙裔黑人;每组n=40）。具体目的是确定与接受安慰剂的女性相比，补充锌的青春期早期女性是否具有：1）有利于骨形成的骨转换标志物的更大增加; 2）血浆IGF-1和IGFBP-3的更大增加; 3）骨转换标志物IGF-1和IGFBP-3的变化因种族而异。此外，还将测定人体测量、成熟偏移、性成熟、红细胞超氧化物歧化酶活性、血浆铜蓝蛋白、饮食摄入量和体力活动。这项研究的结果将提供补充锌是否是一个可行的营养策略，以改善年轻女性骨转换和生长因子的生化指标的初步证据。此外，研究结果将有助于确定是否需要进行长期的临床骨试验，以更明确地评估补充锌降低骨质疏松症风险的潜力。