Psychosocial Stress and the Risk of Uterine Fibroids

社会心理压力和子宫肌瘤的风险

• 批准号: 7285169
• 负责人: ANISSA I VINES
• 金额: $ 3.54万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-11 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7285169
• 关键词: Address; Affect; African American; Age; Age at Menarche; Ancillary Study; Animals; Area; Benign; Biological; Biological Markers; Buffers; Chronic; Condition; Daily; Data; Data Analyses; Development; Diagnosis; Dimensions; Disease; Environmental Health; Epidemiologic Studies; Etiology; Event; Excision; Fibroid Tumor; Goals; Growth; Gynecologic; Health; Health Status; Hormones; Hydrocortisone; Hypertension; Hysterectomy; Institutes; Invasive; Lead; Life; Life Stress; Literature; Logistics; Measures; Menarche; Menopause; Morbidity - disease rate; Nulliparity; Numbers; Obesity; Outcome; Outcome Measure; Pain; Pathogenesis; Pathway interactions; Positioning Attribute; Premenopause; Prevalence; Procedures; Psyche structure; Psychological Stress; Psychology; Psychosocial Stress; Quality of life; Race; Range; Regression Analysis; Reporting; Research; Risk; Risk Factors; Role; Social Class; Socioeconomic Factors; Solutions; Stress; Stressful Event; Time; United States Agency for Healthcare Research and Quality; Uterine Fibroids; Uterus; Woman; Women' s Health; coping; disorder risk; experience; human study; improved; innovation; psychosocial; racial difference; racism; reproductive; reproductive epidemiology; reproductive hormone; research study; statistics; stressor; tumor; urinary

DESCRIPTION (provided by applicant): Significant morbidity due to uterine leiomyomata ("fibroids") affects one of every four to five women in reproductive life. Many women experience severe discomfort that ultimately results in a hysterectomy, an invasive procedure. African American women tend to be at a 2 to 9-fold higher risk of being diagnosed at a younger age and/or with larger more advanced fibroids than white women. The objective of this application is to examine the association between measures of stress and the risk of fibroids among a randomly selected group of premenopausal women between the ages of 35 and 49 years. The literature on known risk factors and the etiology of fibroids is slowing increasing with research suggesting that fibroids are hormonally dependent. Psychosocial stress has been shown to be associated with mental and other physical health outcomes such as obesity and hypertension among women. Evidence of stress causing fluctuations in reproductive hormone levels has been reported in both animal and human studies. The central hypothesis is that fibroids result from an increase in hormone levels as a result of increased levels of stress. Using data from the National Institute of Environmental Health Sciences, Uterine Fibroid Study (UFS), a secondary data analyses is proposed to address four specific aims: 1) Describe the measures of stress (i.e. psychosocial, cortisol, and perceived racism); 2) Examine the association between qualitative measures (i.e. perceived stress and life events stress) psychosocial stress and fibroids; 3) Examine the association between urinary cortisol, a biomarker of stress, and fibroids; and 4) Examine the association between perceived racism and the risk of fibroids among African American women using data from the Perceived Racism Study, an ancillary study to the UFS. Multiple Logistic and Polytomous regression analyses will be used to determine the risk of fibroids associated with stress while controlling for factors such as nulliparity, age at menarche, and increasing age. This research is significant because it is expected to advance and expand our understanding of how stress may manifest in the body and influence fibroid development. The proposed research is an under-investigated area of women's health that has the potential to inform reproductive epidemiology as well as improve our understanding of the pathogenesis of uterine fibroids.

描述（由申请人提供）：子宫平滑肌瘤（“肌瘤”）导致的显着发病率影响着每四到五名处于生育期的女性中的一位。许多女性会经历严重的不适，最终导致子宫切除术，这是一种侵入性手术。与白人女性相比，非裔美国女性在较年轻时被诊断出和/或患有较大、晚期肌瘤的风险往往高 2 至 9 倍。本应用的目的是在随机选择的 35 至 49 岁绝经前女性群体中检查压力测量值与肌瘤风险之间的关联。随着研究表明肌瘤依赖于激素，有关已知风险因素和肌瘤病因的文献正在缓慢增加。社会心理压力已被证明与女性的心理和其他身体健康结果有关，例如肥胖和高血压。动物和人类研究均报告了压力导致生殖激素水平波动的证据。核心假设是，肌瘤是由于压力水平增加而导致激素水平增加所致。使用国家环境健康科学研究所子宫肌瘤研究 (UFS) 的数据，提出了二次数据分析，以解决四个具体目标： 1) 描述压力的测量（即社会心理、皮质醇和感知的种族主义）； 2）检查定性测量（即感知压力和生活事件压力）心理社会压力与肌瘤之间的关联； 3）检查尿皮质醇（压力的生物标志物）与肌瘤之间的关联； 4) 使用“感知种族主义研究”（UFS 的一项辅助研究）的数据，检验非裔美国女性感知到的种族主义与肌瘤风险之间的关联。多重 Logistic 和 Polytomous 回归分析将用于确定与压力相关的肌瘤风险，同时控制未生育、初潮年龄和年龄增长等因素。这项研究意义重大，因为它有望促进和扩大我们对压力如何在体内表现并影响肌瘤发展的理解。拟议的研究是女性健康领域一个尚未得到充分调查的领域，它有可能为生殖流行病学提供信息，并提高我们对子宫肌瘤发病机制的了解。

项目成果

Self-Reported Daily Stress, Squelching of Anger and the Management of Daily Stress and the Prevalence of Uterine Leiomyomata: The Ultrasound Screening Study.

自我报告的日常压力、愤怒的压制和日常压力的管理以及子宫平滑肌瘤的患病率：超声筛查研究。

• DOI: 10.1002/smi.1360
• 发表时间: 2011
• 期刊: Stress and health : journal of the International Society for the Investigation of Stress
• 作者: Vines,AnissaI;Nguyen,ThuThiXuan;Ta,Myduc;Esserman,Denise;Baird,DonnaD
• 通讯作者: Baird,DonnaD

A comparison of the occurrence and perceived stress of major life events in black and white women.

黑人和白人女性重大生活事件的发生率和感知压力的比较。

• DOI: 10.1080/03630240903238743
• 发表时间: 2009
• 期刊: Women & health
• 影响因子: 1.6
• 作者: Vines,AnissaI;Ta,Myduc;Esserman,Denise;Baird,DonnaD
• 通讯作者: Baird,DonnaD