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Vitamin D insufficiency: Prevalence and Impact in Young School Age Children

维生素 D 缺乏：学龄儿童的患病率和影响

基本信息

批准号：
7267661
负责人：
KUMARAVEL RAJAKUMAR
金额：
$ 7.13万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7267661
关键词：
10 year old 12 year old 25-hydroxyvitamin D Achievement Adolescent Adult African American Age Area Body mass index Bone Resorption C-terminal Calcitriol Calcium Caucasians Caucasoid Race Child Child health care Childhood Chronic Clinical Clinical Data Cohort Studies Collagen Type I Colon Carcinoma Data Development Diabetes Mellitus Dietary intake Dihydroxycholecalciferols Ensure Epidemic Fracture Health High Prevalence Hormones Hyperparathyroidism Life Link Longitudinal Studies Maintenance Malabsorption Syndromes Measures Metabolic Multiple Sclerosis Musculoskeletal Normal Range Nutrient Osteogenesis Osteoporosis Outcome Measure Parathyroid Hormones Phosphorus Physiologic calcification Pilot Projects Population Prevalence Prevention Procollagen Public Health Rate Research Design Rickets Risk Sample Size School-Age Population Seasonal Variations Secondary Hyperparathyroidism Serum Skeletal system Sun Exposure United States Vitamin D base bone bone health bone loss bone metabolism bone turnover cohort crosslink human PTH protein muscle strength skeletal disorder

项目摘要

DESCRIPTION (provided by applicant): Vitamin D insufficiency is deemed as an unrecognized epidemic among healthy adults and adolescents residing in the United States. Epidemiologic and clinical data clearly document the high prevalence of vitamin D insufficiency among adults and adolescents. However very little is known regarding the prevalence, seasonal variation and the metabolic impact of vitamin D insufficiency among pre- and early adolescent childhood populations. Using a longitudinal study design, we will estimate the prevalence and seasonal variation of vitamin D insufficiency in 6 to 12 year old pre- and early adolescent children and characterize its metabolic impact on their skeletal health. On the basis of the calculated sample size estimate, a cohort of 140 healthy pre- and early adolescent children (6-12 year old, Tanner I or II, African American [n=94] and Caucasian [n=46]) will be evaluated during summer (June through September) and winter (December through March). Vitamin D status, calcitrophic hormones, and markers of bone turnover will be assessed during summer and winter. Other measures collected will include dietary intakes of vitamin D and calcium, sun exposure and body mass index. Vitamin D insufficiency will be defined as serum 25 hydroxyvitamin D < 20 ng/mL However, on the basis of the relationship between serum 25 hydroxyvitamin D and PTH, the threshold level of serum 25 hydroxyvitamin D essential for vitamin D sufficiency will be determined. This study will establish the prevalence, seasonal variation, and the metabolic impact of vitamin D insufficiency in young school age African American and Caucasian children. The public health importance of childhood vitamin D insufficiency is linked to the impact of vitamin D status on the acquisition of peak bone mass. Reduced peak bone mass will predispose to premature onset of osteoporosis and osteoporotic fragility fractures. Treatment and prevention of vitamin D insufficiency during childhood will positively impact the skeletal health of children and reduce the "osteoporosis burden" during adulthood. The paucity of data regarding threshold vitamin D levels associated with vitamin D sufficiency status among young school age children and the potential likelihood that the threshold serum 25 hydroxyvitamin D levels essential for vitamin D sufficiency could be different between African American and Caucasian children, makes it compelling for this issue to be explored.

描述（由申请人提供）：维生素D不足被认为是居住在美国的健康成年人和青少年中未被认识到的流行病。流行病学和临床数据清楚地表明，成人和青少年中维生素D不足的患病率很高。然而，关于维生素D不足在青春期前和青春期早期儿童人群中的流行率、季节变化和代谢影响，人们知之甚少。采用纵向研究设计，我们将估计6至12岁青春期前和青春期早期儿童维生素D不足的患病率和季节变化，并描述其对骨骼健康的代谢影响。根据计算的样本量估计值，将在夏季（6月至9月）和冬季（12月至3月）对140名健康青春期前和青春期早期儿童（6-12岁，坦纳I或II，非裔美国人[n=94]和高加索人[n=46]）进行评价。维生素D状态，钙营养激素和骨转换标志物将在夏季和冬季进行评估。收集的其他指标将包括维生素D和钙的饮食摄入量，阳光照射和体重指数。维生素D不足定义为血清25羟基维生素D < 20 ng/mL。然而，基于血清25羟基维生素D和PTH之间的关系，将确定维生素D充足所必需的血清25羟基维生素D的阈值水平。这项研究将确定学龄期非洲裔美国人和高加索儿童维生素D不足的患病率、季节变化和代谢影响。儿童期维生素D不足的公共卫生重要性与维生素D状况对峰值骨量获得的影响有关。峰值骨量减少将使骨质疏松症和骨质疏松性脆性骨折过早发作。治疗和预防儿童期维生素D不足将对儿童的骨骼健康产生积极影响，并减少成年期的“骨质疏松症负担”。关于学龄儿童维生素D充足状态与维生素D阈值水平相关的数据缺乏，以及非洲裔美国儿童和高加索儿童维生素D充足所必需的血清25羟维生素D阈值水平可能不同的潜在可能性，使得这一问题值得探讨。