Initiation of Immune Responses to Toxoplasma gondii
Initiation of Immune Responses to Toxoplasma gondii
批准号:
7081704
负责人:
ELLEN A ROBEY
金额:
$31.59万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-04-01 至 2011-06-30
关键词:
T cell receptorToxoplasma gondiiantigen presenting cellbiological signal transductioncell cell interactioncell migrationcellular immunitycytotoxic T lymphocytedisease /disorder modelfibroblastsfluorescence microscopygene mutationgenetically modified animalshelper T lymphocytehost organism interactionimmune responseimmunogeneticslaboratory mousemacrophagemicroorganism immunologyparasite infection mechanismprotozoal antigentoll like receptortoxoplasmosisvirus infection mechanism
中文摘要
细胞内寄生虫弓形虫是B类优先病原体,是主要的食源性病原体,
人类和牲畜的病原体,但很少有人知道如何识别寄生虫,
由免疫系统控制。在目标1中,我们将研究先天免疫信号通路的影响,
在T上。使用成纤维细胞、树突状细胞、巨噬细胞和含有确定的遗传因子的小鼠进行弓形虫感染
病变将特别强调TRAIL-R和FADD(与项目2合作)以及NK
细胞和NK配体NKG2D(与项目3合作)。在目标2中,我们将确定主要的自然资源
在弓形虫感染期间由CDS T细胞识别的抗原。我们假设寄生虫抗原
CD8 T细胞识别的抗原将根据感染的阶段和抗原呈递的类型而变化。
细胞参与。在目标3中,我们将研究先天免疫应答和CD4 T细胞对免疫应答的影响。
CDS T细胞的反应。我们将在缺乏CD4 + T细胞的小鼠中定量CD8 + T细胞对特定抗原的应答,
T细胞或Aim 1中确定的先天免疫途径。我们还将使用双光子成像来检查
目的1和3中免疫应答的动态方面。
英文摘要
The intracellular parasite Toxoplasma gondii is a category B priority pathogen that is a major food borne
pathogen of humans and livestock, but very little is known about how the parasite is recognized and
controlled by the immune system. In Aim 1 we will examine the impact of innate immune signaling pathways
on T. gondii infection using fibroblasts, dendritic cells, macrophage and mice containing defined genetic
lesions. Particular emphasis will be placed on TRAIL-R and FADD (in collaboration with Project 2) and NK
cells and the NK ligand NKG2D (in collaboration with Project 3). In Aim 2 we will identify the major natural
antigens recognized by CDS T cells during Toxoplasma infection. We hypothesize that the parasite antigens
recognized by CDS T cells will vary depending on the stage of infection and the type of antigen presenting
cells involved. In Aim 3, we will examine the impact of innate immune responses and CD4 T cells on the
response of CDS T cells. We will quantitate CDS T cell responses to particular antigens in mice lacking CD4
T cells or the innate immune pathways identified in Aim 1. We will also use 2-photon imaging to examine the
dynamic aspects of immune responses in Aims 1 and 3.
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科研奖励(0)
会议论文
Signals that Control Thymocyte Migration
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批准号:10753064
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项目类别:
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资助金额:$46.76万
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财政年份:2023
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负责人:ELLEN A ROBEY
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依托单位:
Spatial and temporal mapping of cell fate within lymphoid tissue
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批准号:10468207
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项目类别:
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资助金额:$64.77万
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财政年份:2020
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负责人:ELLEN A ROBEY
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依托单位:
Spatial and temporal mapping of cell fate within lymphoid tissue
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批准号:10682561
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项目类别:
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资助金额:$64.77万
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财政年份:2020
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负责人:ELLEN A ROBEY
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依托单位:
Spatial and temporal mapping of cell fate within lymphoid tissue
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批准号:10261359
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项目类别:
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资助金额:$64.77万
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财政年份:2020
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负责人:ELLEN A ROBEY
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依托单位:
Immunology and Pathogenesis Program Training Grant
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批准号:10421298
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项目类别:
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资助金额:$39.82万
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财政年份:2012
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负责人:ELLEN A ROBEY
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依托单位:
Immunology & Pathogenesis Program Training Grant
-
批准号:8476201
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项目类别:
-
资助金额:$27.37万
-
财政年份:2012
-
负责人:ELLEN A ROBEY
-
依托单位:
Immunology & Pathogenesis Program Training Grant
-
批准号:9395060
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项目类别:
-
资助金额:$0.3万
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财政年份:2012
-
负责人:ELLEN A ROBEY
-
依托单位:
Immunology & Pathogenesis Program Training Grant
-
批准号:8838041
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项目类别:
-
资助金额:$28.61万
-
财政年份:2012
-
负责人:ELLEN A ROBEY
-
依托单位:
Immunology & Pathogenesis Program Training Grant
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批准号:8664792
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项目类别:
-
资助金额:$27.44万
-
财政年份:2012
-
负责人:ELLEN A ROBEY
-
依托单位:
Immunology and Pathogenesis Program Training Grant
-
批准号:9754761
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项目类别:
-
资助金额:$35.52万
-
财政年份:2012
-
负责人:ELLEN A ROBEY
-
依托单位:
Regulation of T cell responses during chronic infection by Toxoplasma gondii
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批准号:8291200
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项目类别:
-
资助金额:$19.19万
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财政年份:2011
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负责人:ELLEN A ROBEY
-
依托单位:
Regulation of T cell responses during chronic infection by Toxoplasma gondii
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批准号:8706016
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项目类别:
-
资助金额:$19.19万
-
财政年份:2011
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负责人:ELLEN A ROBEY
-
依托单位:
Regulation of T cell responses during chronic infection by Toxoplasma gondii
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批准号:8868896
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项目类别:
-
资助金额:$19.19万
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财政年份:2011
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负责人:ELLEN A ROBEY
-
依托单位:
Regulation of T cell responses during chronic infection by Toxoplasma gondii
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批准号:8063231
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项目类别:
-
资助金额:$19.19万
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财政年份:2011
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负责人:ELLEN A ROBEY
-
依托单位:
Regulation of T cell responses during chronic infection by Toxoplasma gondii
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批准号:8501348
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项目类别:
-
资助金额:$18.04万
-
财政年份:2011
-
负责人:ELLEN A ROBEY
-
依托单位:
Expanding and upgrading a custom built 2-photon microscope for time lapse fluores
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批准号:7792784
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项目类别:
-
资助金额:$47.17万
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财政年份:2010
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负责人:ELLEN A ROBEY
-
依托单位:
Imaging Core
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批准号:7081711
-
项目类别:
-
资助金额:$41.7万
-
财政年份:2006
-
负责人:ELLEN A ROBEY
-
依托单位:
Signals that Control Thymocyte Migration
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批准号:9107097
-
项目类别:
-
资助金额:$38.33万
-
财政年份:2006
-
负责人:ELLEN A ROBEY
-
依托单位:
Signals That Control Thymocyte Migration
-
批准号:8889608
-
项目类别:
-
资助金额:$37.26万
-
财政年份:2006
-
负责人:ELLEN A ROBEY
-
依托单位:
Signals that control thymocyte migration
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批准号:7409149
-
项目类别:
-
资助金额:$35.67万
-
财政年份:2006
-
负责人:ELLEN A ROBEY
-
依托单位:
海外基金