DESIGN, RANDOMIZATION AND ANALYSIS CORE

随机和分析核心(核心D)专注于为我们的科学研究人员提供 确保成功实施所需的一流统计推理和分析支持 以及对拟议的体验团(EC)试验的分析。它的具体目标是履行四项关键职能。 首先，核心将支持设计和实施欧共体学校和老年人的随机化 志愿者。第二，它将为有效地实现这一目标提供协调的统计支持 通过在统计分析和设计的所有项目中与调查人员合作来规划项目 规范多个项目共享的高层次分析应用。第三，它将作为一个 通过协助招聘和为其他EC核心提供智力伙伴关系和量化资源 留住核心(核心B)S对招聘、留住和招聘有效性的评价 针对不同子组的消息和策略；协助数据收集和管理 核心(核心C)S对分析数据集的质量控制分析和开发； 行政核心(核心A)和项目调查员对以下结果的集体理解 具体研究。最后，与Core，C合作，Core D将支持数据安全和 监测委员会分析不良事件并及时提供适当数据。通过 为这个项目引入大量专门的统计专业知识、基础设施和人员，我们将 能够克服社区试验给统计分析带来的严峻挑战，从而 提高我们获取关键证据的能力，这些证据是地方和国家采取高质量所需的 计划的规模，以改善我们的老年人的健康，并支持我们的孩子的成功。

The Randomization and Analysis Core (Core D) is focused on empowering our scientific investigators with first-rate statistical reasoning and analytic support that are needed to ensure the successful implementation and analysis of the proposed Experience Corps (EC) Trials. It specifically aims to perform four key functions. First, the Core will support for the design and Implementation of randomization of EC schools and older adult volunteers. Second it will provide coordinated statistical support for validly addressing the aims of this Program Project by collaborating with investigators in all projects in the design of statistical analyses and standardizing the application of high-level analyses shared by multiple projects. Third, it will serve as an intellectual partnership and quantitative resource for other EC cores by assisting the Recruitment and Retention Core (Core B)'s evaluation of the effectiveness of recruitment, retention, and recruitment messages and strategies targeting different subgroups; assisting with the Data Collection and management Core (Core C)'s quality control analyses and development of analytic datasets; and contributing to the collective understanding by the Administrative Core (Core A) and project investigators of the results from specific studies. Finally, in collaboration with Core, C, Core D will support the needs of the Data safety and Monitoring Board by analysis of adverse events and provision of appropriate data in a timely manner. By bringing in a critical mass of dedicated statistical expertise, infrastructure, and staffing to this project, we will be able to overcome the serious challenges that community trials poses for statistical analysis and hence improve our ability to derive critical evidence that is needed locally and nationally to take a high quality program to scale to improve the health of our senior citizens and support the success of our children.