DESIGN, RANDOMIZATION AND ANALYSIS CORE

设计、随机化和分析核心

• 批准号: 7114740
• 负责人: CONSTANTINE E FRANGAKIS
• 金额: $ 6.43万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114740
• 关键词: academic achievement; aging; behavioral /social science research tag; biomedical facility; data quality /integrity; elementary school; experimental designs; functional ability; health science research analysis /evaluation; human data; human old age (65+); interdisciplinary collaboration; middle childhood (6-11); quality of life; social model; statistical service /center; statistics /biometry; volunteer

The Randomization and Analysis Core (Core D) is focused on empowering our scientific investigators with first-rate statistical reasoning and analytic support that are needed to ensure the successful implementation and analysis of the proposed Experience Corps (EC) Trials. It specifically aims to perform four key functions. First, the Core will support for the design and Implementation of randomization of EC schools and older adult volunteers. Second it will provide coordinated statistical support for validly addressing the aims of this Program Project by collaborating with investigators in all projects in the design of statistical analyses and standardizing the application of high-level analyses shared by multiple projects. Third, it will serve as an intellectual partnership and quantitative resource for other EC cores by assisting the Recruitment and Retention Core (Core B)'s evaluation of the effectiveness of recruitment, retention, and recruitment messages and strategies targeting different subgroups; assisting with the Data Collection and management Core (Core C)'s quality control analyses and development of analytic datasets; and contributing to the collective understanding by the Administrative Core (Core A) and project investigators of the results from specific studies. Finally, in collaboration with Core, C, Core D will support the needs of the Data safety and Monitoring Board by analysis of adverse events and provision of appropriate data in a timely manner. By bringing in a critical mass of dedicated statistical expertise, infrastructure, and staffing to this project, we will be able to overcome the serious challenges that community trials poses for statistical analysis and hence improve our ability to derive critical evidence that is needed locally and nationally to take a high quality program to scale to improve the health of our senior citizens and support the success of our children.

随机化和分析核心（核心 D）致力于为我们的科学研究人员提供以下能力： 确保成功实施所需的一流统计推理和分析支持 以及对拟议的体验团 (EC) 试验的分析。它的具体目标是执行四个关键功能。 首先，核心将支持 EC 学校和老年人随机化的设计和实施 志愿者。其次，它将为有效实现本目标提供协调一致的统计支持。 计划项目通过与所有项目的研究人员合作设计统计分析和 标准化多个项目共享的高级分析的应用。第三，它将作为一个 通过协助招聘和其他 EC 核心的智力合作和定量资源 Retention Core（核心B）对招聘、保留和招聘有效性的评估 针对不同亚群体的信息和战略；协助数据收集和管理 核心（核心C）的质量控制分析和分析数据集的开发；并为 行政核心（核心 A）和项目调查员对结果的集体理解 具体研究。最后，Core D 与 Core、C 合作，将支持数据安全和 监测委员会通过分析不良事件并及时提供适当的数据。经过 为该项目引入大量专门的统计专业知识、基础设施和人员配置，我们将 能够克服社区试验对统计分析带来的严峻挑战，从而 提高我们获取当地和全国所需的关键证据的能力，以获取高质量的证据 计划扩大规模，以改善老年人的健康并支持我们的孩子的成功。