Glycomic control of cartilage extra cellular matrix turnover

天然存在的小糖分子控制软骨基质周转。我们已经合成了天然分子的小合成类似物，并证明了它们调节信号通路的能力。该项目将在细胞和组织分析中测试和数学建模合成分子，以确定其特性和组织效应，并评估其作为药物输送系统的适用性。研究结果将是设计治疗骨关节炎和其他软骨疾病的新方法的重要一步。

Small, naturally occurring glycomic molecules control cartilage matrix turnover. We have synthesised small synthetic analogues of the naturally occurring molecules, and demonstrated their ability to regulate signalling pathways. This project will test and mathematical model the synthetic molecules in cell and tissue assays to define their properties and tissue effects, and assess their suitability as a drug delivery system. The results will be an important step towards designing new ways of treating osteoarthritis and other cartilage diseases.