Glycomic control of cartilage extra cellular matrix turnover

软骨细胞外基质周转的糖组控制

• 批准号: nhmrc : 1051455
• 负责人: Prof Alan Grodzinsky
• 金额: $ 47.1万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glycomic-control-cartilage-matrix-turnover/112215
• 关键词: Glycomic; control; cartilage; extra; cellular

Small, naturally occurring glycomic molecules control cartilage matrix turnover. We have synthesised small synthetic analogues of the naturally occurring molecules, and demonstrated their ability to regulate signalling pathways. This project will test and mathematical model the synthetic molecules in cell and tissue assays to define their properties and tissue effects, and assess their suitability as a drug delivery system. The results will be an important step towards designing new ways of treating osteoarthritis and other cartilage diseases.

天然存在的小糖糖分子控制软骨基质的周转。我们已经合成了天然分子的小合成类似物，并证明了它们调节信号通路的能力。该项目将在细胞和组织分析中对合成分子进行测试和数学建模，以确定它们的性质和组织效应，并评估它们作为药物输送系统的适用性。该结果将是设计治疗骨关节炎和其他软骨疾病的新方法的重要一步。