Stem cell, tumor and bone marrow microenvironment cross-talk in vivo

体内干细胞、肿瘤和骨髓微环境的串扰

基本信息

  • 批准号:
    7430502
  • 负责人:
  • 金额:
    $ 230.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-09-30 至 2012-08-31
  • 项目状态:
    已结题

项目摘要

A growing body of evidence suggests that the host microenvironment plays an important role in the regulation of both normal and malignant stem cell self-renewal and differentiation. The specific locations, cellular components and molecular details of these stem cell niches are, however, little understood. Using in vivo confocal and multiphoton molecular imaging techniques to study cell interactions in the intact murine bone marrow (BM), we have defined a novel perivascular tumor and hematopoietic stem/progenitor cell (HSPC) niche. We have identified the molecules used by leukemic cells to access this niche, however the mechanisms governing HSC transit to these areas have not yet been defined. Moreover, the role of this niche in maintaining normal HSCs or coordinating specific HSC cell functions is unknown. Given the importance of HSC-based transplantation therapies as well as the clinical significance of tumor metastasis to the BM, there is great therapeutic potential in understanding these cellular interactions. The long-term goals of our research are, therefore, to define the molecular architecture and functional significance of this tumor and HSC niche using state-of-the-art in vivo imaging techniques combined with cell and molecular biology approaches. Specifically, we will 1) examine the mechanisms governing HSC transit and engraftment in these niches, 2) determine how tumor growth impacts the niche and whether tumor and benign HSCs compete within the niche, and 3) develop targeted nanoparticles to release encapsulated compounds in precise regions of the vascular niche. These nanoparticles will serve as a unique tool to elucidate the critical molecules that mediate HSC and tumor proliferation in the niche and as a prototype for a targeted drug delivery agent. Ultimately, we aim to use the knowledge from these studies to design specific anti-tumor treatments that spare normal hematopoiesis and to define factors that improve the efficacy of stem cell-based therapies.
越来越多的证据表明,宿主微环境在细胞凋亡过程中起着重要作用

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Dorothy A Sipkins其他文献

Dorothy A Sipkins的其他文献

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{{ truncateString('Dorothy A Sipkins', 18)}}的其他基金

Identifying and exploiting therapeutic vulnerabilities of tumor-host interactions that drive bone-to-meninges breast cancer metastasis
识别和利用导致骨到脑膜乳腺癌转移的肿瘤与宿主相互作用的治疗脆弱性
  • 批准号:
    10826488
  • 财政年份:
    2023
  • 资助金额:
    $ 230.25万
  • 项目类别:
Novel use of PI3K inhibition to prevent recurrence of B-cell acute lymphoblastic leukemia
PI3K 抑制预防 B 细胞急性淋巴细胞白血病复发的新用途
  • 批准号:
    10455633
  • 财政年份:
    2021
  • 资助金额:
    $ 230.25万
  • 项目类别:
Novel use of PI3K inhibition to prevent recurrence of B-cell acute lymphoblastic leukemia
PI3K 抑制预防 B 细胞急性淋巴细胞白血病复发的新用途
  • 批准号:
    10289183
  • 财政年份:
    2021
  • 资助金额:
    $ 230.25万
  • 项目类别:
Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis
定义和靶向中枢神经系统软脑膜转移的新途径
  • 批准号:
    10322127
  • 财政年份:
    2020
  • 资助金额:
    $ 230.25万
  • 项目类别:
Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis
定义和针对中枢神经系统软脑膜转移的新途径
  • 批准号:
    10553654
  • 财政年份:
    2020
  • 资助金额:
    $ 230.25万
  • 项目类别:
Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis
定义和靶向中枢神经系统软脑膜转移的新途径
  • 批准号:
    9888134
  • 财政年份:
    2020
  • 资助金额:
    $ 230.25万
  • 项目类别:
Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis
定义和针对中枢神经系统软脑膜转移的新途径
  • 批准号:
    10079480
  • 财政年份:
    2020
  • 资助金额:
    $ 230.25万
  • 项目类别:
Defining the Rules of Breast Cancer Cell Traffic Through Bone
定义乳腺癌细胞通过骨运输的规则
  • 批准号:
    10368923
  • 财政年份:
    2017
  • 资助金额:
    $ 230.25万
  • 项目类别:
Defining the Rules of Breast Cancer Cell Traffic Through Bone
定义乳腺癌细胞通过骨运输的规则
  • 批准号:
    10066311
  • 财政年份:
    2017
  • 资助金额:
    $ 230.25万
  • 项目类别:
Defining the Rules of Breast Cancer Cell Traffic Through Bone
定义乳腺癌细胞通过骨运输的规则
  • 批准号:
    9239952
  • 财政年份:
    2017
  • 资助金额:
    $ 230.25万
  • 项目类别:

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