Effects of Physical Activity on Hippocampal Neurogenesis

体力活动对海马神经发生的影响

• 批准号: 7251927
• 负责人: Alexis M. Stranahan
• 金额: $ 3.8万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7251927
• 关键词: Adrenal Glands; Adult; Affect; Brain; Bromodeoxyuridine; Cardiovascular system; Cell Proliferation; D Aspartate; Data; Dementia; Elderly; Elevation; Environment; Environmental Risk Factor; Exercise; Fellowship; Frequencies; Goals; Hippocampus (Brain); Histone H3; Incidence; Individual; Learning; Measures; Mus; Names; Neurodegenerative Disorders; Neurons; Numbers; Ovarian hormone; Physical activity; Physiological; Prevention; Process; Rattus; Receptor Activation; Research; Research Proposals; Role; Running; Steroids; Stress; Structure; Thymidine; Time; analog; aspartate receptor; day; dentate gyrus; neurogenesis; psychologic

DESCRIPTION (provided by applicant): The brain continues to generate new neurons in the hippocampus throughout adulthood. The process of neurogenesis is influenced by environmental factors such as learning, stress, spatial complexity, and physical activity. The proposed research will explore the control of neurogenesis by wheel running activity, and investigate the temporal and physiological parameters of this phenomenon. In addition, the volitional aspect of exercise will be examined using forced treadmill and voluntary running wheel activity. The thymidine analog 5-bromodeoxyuridine (BrdU) is typically used in studies of cell proliferation and survival in the hippocampus. However, when studying environmental factors that elevate the circulatory system, the issue of availability causes difficulty in interpretation of results. To this end, immunolabeling for the endogenous markers Ki-67 and phospho-histone H3 will be applied to provide a measure of exercise-induced neurogenesis that is not affected by systemic elevation. Physical activity has been correlated with a lower incidence of dementia in older adults, and the data from studies of exercise-induced neurogenesis may one day be applied to the prevention or treatment of neurodegenerative disease.

描述（由申请人提供）：整个成年期，大脑继续在海马体中产生新的神经元。神经发生的过程受到环境因素的影响，如学习、压力、空间复杂性和体力活动。本研究将探讨轮跑活动对神经发生的控制，并研究这一现象的时间和生理参数。此外，意志方面的运动将检查使用强制跑步机和自愿运行轮活动。胸苷类似物5-溴脱氧尿苷（BrdU）通常用于海马中细胞增殖和存活的研究。然而，在研究提高循环系统的环境因素时，可用性问题导致难以解释结果。为此，将应用内源性标记物Ki-67和磷酸化组蛋白H3的免疫标记来提供不受全身升高影响的运动诱导的神经发生的测量。体育活动与老年人痴呆症的发病率较低有关，运动诱导神经发生的研究数据有朝一日可能会应用于预防或治疗神经退行性疾病。

项目成果

Physiological variability in brain-derived neurotrophic factor expression predicts dendritic spine density in the mouse dentate gyrus.

• DOI: 10.1016/j.neulet.2011.03.037
• 发表时间: 2011-05-09
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Stranahan AM

Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice.

• DOI: 10.1016/j.neurobiolaging.2008.10.016
• 发表时间: 2010-11
• 期刊: NEUROBIOLOGY OF AGING
• 影响因子: 4.2
• 作者: Stranahan, Alexis M.;Lee, Kim;Becker, Kevin G.;Zhang, Yonqing;Maudsley, Stuart;Martin, Bronwen;Cutler, Roy G.;Mattson, Mark P.
• 通讯作者: Mattson, Mark P.

Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility.

海马可塑性受损和神经变性导致与年龄相关的荷尔蒙搏动缺陷。

• DOI: 10.1016/j.arr.2007.12.004
• 发表时间: 2008
• 期刊: Ageing research reviews
• 影响因子: 13.1
• 作者: Stranahan,AlexisM;Lee,Kim;Mattson,MarkP
• 通讯作者: Mattson,MarkP

Impact of energy intake and expenditure on neuronal plasticity.

能量摄入和消耗对神经元可塑性的影响。

• DOI: 10.1007/s12017-008-8043-0
• 发表时间: 2008
• 期刊: Neuromolecular medicine
• 影响因子: 3.5
• 作者: Stranahan,AlexisM;Mattson,MarkP
• 通讯作者: Mattson,MarkP