Self-injury: Pain and Stress Mechanisms

自残：疼痛和压力机制

• 批准号: 7142288
• 负责人: FRANK J SYMONS
• 金额: $ 10.61万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-22 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7142288
• 关键词: behavioral /social science research tag; child psychology; clinical research; coping; cortisol; developmental disease /disorder; early experience; human subject; hypothalamic pituitary adrenal axis; longitudinal human study; neuroregulation; pain; pathologic process; preschool child (1-5); psychoanalysis; saliva; self destructive behavior; sensory thresholds; stress

DESCRIPTION (provided by applicant): Goals: My research has dealt primarily with the behavioral mechanisms underlying chronic SIB among individuals with developmental disorders. A more complete understanding of the pathophysiology of SIB will require integrating our rich understanding of pain neurobiology and stress psychobiology with our emerging understanding of the role of early experience on multiple pain and stress-sensitive physiological systems. Research: During my R29 funding period, I extended the opioid model of SIB in line with clinical features suggestive of altered pain processing, formed collaborative relations, and began developing the necessary expertise allowing me to seek funding to test an integrative pain and stress model of SIB in adults. The purpose of the funded R01 is to compare socially and nonsocially-mediated SIB adult cases on a set of behavioral and biological measures related to sensory function, stress physiology, and pain behavior. Career Plan: The career development plan uses a translational research training framework as an organizing set of principles to guide research and training goals specific to new developments in neuroscience and behavioral genetics, integrating the wider research program of developmental psychopathology, and expanding the self- injury research agenda to embrace gene-environmental interplay and improve our understanding of individual vulnerability. Preliminary work and collaborative relations are described to support the need for release time to enhance my training and research into these related areas. The plan emphasizes the need to extend self- injury research to issues germane to pediatric and neurological research (i.e., pain regulation, high risk populations), and to include other systems important in the regulation of pain (i.e., peripheral and central transmission mechanisms), stress (i.e., the HPA axis), and the autonomic nervous system (i.e., fronto-limbic and autonomic circuitry). Specifically, I want to gain the expertise to test the following three preliminary hypotheses. First, there will be differences in hypothalamic-pituitary-adrenal (HPA) axis activity (cortisol) and sensory function (detection thresholds) in children with severe neurological impairment and self-injury compared with matched controls without self-injury (between group analyses). Second: the frequency and temporal sequencing of self-injury will be correlated with HPA axis activity and sensory function (within group analyses). Third, the relation between HPA axis activity, sensory function, and SIB will change over time such that the degree of dysregulation in the former predicts increasing severity in the latter (prospective analysis). Institution and Environment Commitment: The Department of Educational Psychology and the University of Minnesota are committed to this award and provide rich resources for my career development.

描述（由申请人提供）：目标：我的研究主要涉及发育障碍个体慢性SIB的行为机制。要更全面地了解SIB的病理生理学，需要将我们对疼痛神经生物学和应激心理生物学的丰富理解与我们对早期经验在多种疼痛和应激敏感生理系统中的作用的新认识相结合。研究：在我的R29资助期间，我根据提示疼痛处理改变的临床特征扩展了SIB的阿片样物质模型，形成了合作关系，并开始发展必要的专业知识，使我能够寻求资金来测试成人SIB的综合疼痛和压力模型。资助的R 01的目的是比较社会和非社会介导的SIB成人病例的一组行为和生物学措施相关的感觉功能，应激生理学和疼痛行为。职业规划：职业发展计划使用转化研究培训框架作为一套组织原则，以指导针对神经科学和行为遗传学新发展的研究和培训目标，整合更广泛的发展性精神病理学研究计划，并扩展自我伤害研究议程，以拥抱基因-环境相互作用并提高我们对个体脆弱性的理解。初步工作和合作关系的描述，以支持需要释放时间，以加强我的培训和研究到这些相关领域。该计划强调有必要将自伤研究扩展到与儿科和神经学研究密切相关的问题（即，疼痛调节，高危人群），并包括在疼痛调节中重要的其它系统（即，外围和中心传动机构），应力（即，HPA轴），和自主神经系统（即，额边缘和自主电路）。具体来说，我想获得专业知识来测试以下三个初步假设。首先，与无自伤的对照组相比，有严重神经功能缺损和自伤的儿童的下丘脑-垂体-肾上腺（HPA）轴活动（皮质醇）和感觉功能（检测阈值）存在差异（组间分析）。第二：自伤的频率和时间顺序将与HPA轴活动和感觉功能相关（组内分析）。第三，HPA轴活动、感觉功能和SIB之间的关系将随着时间的推移而改变，使得前者的失调程度预测后者的严重程度增加（前瞻性分析）。机构和环境承诺：教育心理学系和明尼苏达大学致力于这个奖项，并为我的职业发展提供丰富的资源。