Self-injury: Pain and Stress Mechanisms

自残：疼痛和压力机制

• 批准号: 7142288
• 负责人: FRANK J SYMONS
• 金额: $ 10.61万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-22 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7142288
• 关键词: behavioral /social science research tag; child psychology; clinical research; coping; cortisol; developmental disease /disorder; early experience; human subject; hypothalamic pituitary adrenal axis; longitudinal human study; neuroregulation; pain; pathologic process; preschool child (1-5); psychoanalysis; saliva; self destructive behavior; sensory thresholds; stress

DESCRIPTION (provided by applicant): Goals: My research has dealt primarily with the behavioral mechanisms underlying chronic SIB among individuals with developmental disorders. A more complete understanding of the pathophysiology of SIB will require integrating our rich understanding of pain neurobiology and stress psychobiology with our emerging understanding of the role of early experience on multiple pain and stress-sensitive physiological systems. Research: During my R29 funding period, I extended the opioid model of SIB in line with clinical features suggestive of altered pain processing, formed collaborative relations, and began developing the necessary expertise allowing me to seek funding to test an integrative pain and stress model of SIB in adults. The purpose of the funded R01 is to compare socially and nonsocially-mediated SIB adult cases on a set of behavioral and biological measures related to sensory function, stress physiology, and pain behavior. Career Plan: The career development plan uses a translational research training framework as an organizing set of principles to guide research and training goals specific to new developments in neuroscience and behavioral genetics, integrating the wider research program of developmental psychopathology, and expanding the self- injury research agenda to embrace gene-environmental interplay and improve our understanding of individual vulnerability. Preliminary work and collaborative relations are described to support the need for release time to enhance my training and research into these related areas. The plan emphasizes the need to extend self- injury research to issues germane to pediatric and neurological research (i.e., pain regulation, high risk populations), and to include other systems important in the regulation of pain (i.e., peripheral and central transmission mechanisms), stress (i.e., the HPA axis), and the autonomic nervous system (i.e., fronto-limbic and autonomic circuitry). Specifically, I want to gain the expertise to test the following three preliminary hypotheses. First, there will be differences in hypothalamic-pituitary-adrenal (HPA) axis activity (cortisol) and sensory function (detection thresholds) in children with severe neurological impairment and self-injury compared with matched controls without self-injury (between group analyses). Second: the frequency and temporal sequencing of self-injury will be correlated with HPA axis activity and sensory function (within group analyses). Third, the relation between HPA axis activity, sensory function, and SIB will change over time such that the degree of dysregulation in the former predicts increasing severity in the latter (prospective analysis). Institution and Environment Commitment: The Department of Educational Psychology and the University of Minnesota are committed to this award and provide rich resources for my career development.

描述（由申请人提供）：目的：我的研究主要涉及发育障碍个体慢性SIB的行为机制。要更全面地了解SIB的病理生理学，需要将我们对疼痛神经生物学和应激心理生物学的丰富理解与我们对早期经历在多种疼痛和应激敏感生理系统中的作用的新兴理解结合起来。研究：在R29资助期间，我根据提示疼痛处理改变的临床特征扩展了SIB的阿片类药物模型，形成了合作关系，并开始发展必要的专业知识，使我能够寻求资金来测试成人SIB的综合疼痛和压力模型。资助的R01的目的是比较社会和非社会介导的SIB成人病例在一系列与感觉功能、应激生理和疼痛行为相关的行为和生物学指标。职业发展计划：职业发展计划使用转化研究培训框架作为一套有组织的原则来指导研究和培训目标，具体到神经科学和行为遗传学的新发展，整合更广泛的发展精神病理学研究项目，扩大自我伤害研究议程，包括基因-环境相互作用，提高我们对个体脆弱性的理解。初步的工作和协作关系被描述为支持发布时间的需要，以加强我在这些相关领域的培训和研究。该计划强调需要将自伤研究扩展到与儿科和神经学研究相关的问题（即疼痛调节，高风险人群），并包括其他在疼痛调节中重要的系统（即外周和中枢传递机制），压力（即HPA轴）和自主神经系统（即额边缘和自主神经回路）。具体来说，我想获得专业知识来检验以下三个初步假设。首先，有严重神经损伤和自残的儿童与没有自残的对照组相比，下丘脑-垂体-肾上腺（HPA）轴活性（皮质醇）和感觉功能（检测阈值）存在差异（组间分析）。第二：自我伤害的频率和时间顺序将与下丘脑轴活动和感觉功能相关（组内分析）。第三，下丘脑轴活动、感觉功能和SIB之间的关系会随着时间的推移而改变，因此前者的失调程度预示着后者的严重程度会增加（前瞻性分析）。机构和环境承诺：教育心理学系和明尼苏达大学致力于这个奖项，并为我的职业发展提供丰富的资源。