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Intrathecal Baclofen and Pain Outcomes in Cerebral Palsy

鞘内注射巴氯芬与脑瘫的疼痛结果

基本信息

批准号：
9244672
负责人：
FRANK J SYMONS
金额：
$ 48.48万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9244672
关键词：
Activities of Daily Living Address Analgesics Baclofen Belief Biological Biological Markers Caregivers Catheters Cerebral Palsy Cerebrospinal Fluid Characteristics Child Chronic Chronic disabling pain Clinical Cognitive Congenital musculoskeletal anomalies Data Decision Making Distress Dose Equilibrium Failure Family Family member Frequencies Goals Health Personnel Immune Impairment Implant Individual Differences Inflammation Inflammatory Knowledge Measurement Measures Modeling Motor Muscle Contraction Muscle Spasticity Muscular Dystrophies Musculoskeletal Neurodevelopmental Disability Neurodevelopmental Disorder Neurosecretory Systems Nociception Operative Surgical Procedures Oral Outcome Pain Pain Nature Pain Research Pain management Patient Selection Patients Physiological Physiology Population Procedures Process Prospective Studies Proxy Psychosocial Factor Public Health Pump Quality of life Reporting Research Rett Syndrome Risk Sampling Schedule Scientific Advances and Accomplishments Selection Criteria Seroma Severities Spastic Stress Structure Subgroup Syndrome System Testing Treatment outcome Vulnerable Populations Withdrawal Work Wound Infection chronic pain clinical decision-making clinically relevant design disability experience functional outcomes improved innovation insight novel outcome prediction primary outcome prospective prospective test psychosocial public health relevance response spasticity treatment effect treatment response

项目摘要

DESCRIPTION (provided by applicant): This application addresses PA 10-006 Mechanisms, Models, Measurement, and Management in Pain Research (R01). The majority of children with cerebral palsy (CP) live with spasticity and spasticity-induced disabling chronic pain. One of the front-line treatments for spasticity involves surgically implanting a pump to intrathecally deliver baclofen (ITB). Doing so avoids the problems with orally administered baclofen but creates problems of its own including general surgical risks but also procedure specific issues such as cerebral spinal fluid (CSF) leaks and catheter malfunction leading to serious withdrawal complications. Thus, the procedure is not without risk, but on balance the evidence is tilted toward efficacy for spasticity outcomes by reducing spasticity. It is less clear, however, whether the chronic pain is also and always reduced. There are mixed and muddled results specific to pain outcomes; mixed because in some studies pain is reported to decrease but in others there is no apparent change, muddled because the majority of the studies are poorly designed with pain poorly measured and so the results are scientifically uncertain and clinically ambiguous. This specific problem - whether or not pain improves following ITB treatment - is part of a much broader general issue - whether we can use scientific advances from pain research to improve our clinical understanding of pain and disability among children with significant intellectual, motor, and communicative impairments associated with neurodevelopmental disorders. The overall goal of this application is to initiate a line of research with the primary objective of improving our scientific understanding of changes in chronic pain in response to treatment among children with significant neurodevelopmental disabilities. The specific purpose of this interdisciplinary translational proposal is to clarify the clinical ambiguity in pain outcomes in relation to ITB treatment by prospectively studying a sample of children with CP and spasticity before and after ITB implant. By doing so, we will be able to (a) examine in detail the relation between changes in spasticity and pain, (b) evaluate whether pain that persists even in the presence of reduced spasticity will be associated with poorer functional outcomes, and (c) empirically test whether treatment parameters associated with the pump implant, clinical features associated with CP, or physiological variables associated with pain, stress, and inflammation interact to influence pain specific treatment outcomes. To date, there has been no comprehensive study specific to chronic pain among children with CP treated with ITB pump implants. Considering the vulnerable clinical population for the proposed project, we believe there is an urgent imperative to try to make scientific advances from the 'bench' relevant to real-world pain and disability problems. Ultimately, the knowledge gain should transfer into a clinical decision making aide with respect to improving patient selection criteria and by informing patients, their families, and healthcare providers more completely about the full range of expected outcomes with respect to pain and function.

描述（由申请人提供）：本申请涉及PA 10-006疼痛研究中的机制、模型、测量和管理（R 01）。大多数脑瘫儿童都患有痉挛和痉挛引起的致残性慢性疼痛。痉挛的一线治疗方法之一是通过手术植入一个泵，巴氯芬（ITB）。这样做避免了口服巴氯芬的问题，但也产生了其自身的问题，包括一般手术风险，以及手术特定问题，如脑脊液（CSF）泄漏和导管故障，导致严重的撤回并发症。因此，该手术并非没有风险，但总的来说，证据倾向于通过减少痉挛来改善痉挛结局。然而，尚不清楚慢性疼痛是否也总是减少。具体到疼痛结果，结果混杂而混乱;混杂是因为在一些研究中，疼痛被报告为减少，但在其他研究中没有明显的变化，混乱是因为大多数研究设计不良，疼痛测量不良，因此结果在科学上不确定，临床上模棱两可。这个具体问题-ITB治疗后疼痛是否改善-是一个更广泛的一般问题的一部分-我们是否可以利用疼痛研究的科学进展来提高我们对患有与神经发育障碍相关的严重智力、运动和交流障碍的儿童的疼痛和残疾的临床理解。本申请的总体目标是启动一系列研究，其主要目标是提高我们对慢性疼痛变化的科学理解，以应对患有严重神经发育障碍的儿童的治疗。本跨学科翻译提案的具体目的是通过前瞻性研究ITB植入前后的CP和痉挛儿童样本，澄清与ITB治疗相关的疼痛结局的临床模糊性。通过这样做，我们将能够（a）详细检查痉挛状态和疼痛变化之间的关系，（B）评估即使在痉挛状态减轻的情况下持续存在的疼痛是否与较差的功能结局相关，以及（c）经验性地测试与泵植入物相关的治疗参数、与CP相关的临床特征或与疼痛、压力、和炎症相互作用以影响疼痛特异性治疗结果。到目前为止，还没有专门针对接受ITB泵植入物治疗的CP儿童慢性疼痛的综合研究。考虑到拟议项目的脆弱临床人群，我们认为迫切需要尝试从“板凳”上取得与现实世界疼痛和残疾问题相关的科学进步。最终，获得的知识应转化为临床决策辅助工具，以改善患者选择标准，并更完整地告知患者、其家属和医疗保健提供者疼痛和功能方面的全部预期结局。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Psychometric properties of the brief pain inventory modified for proxy report of pain interference in children with cerebral palsy with and without cognitive impairment.

DOI：
10.1097/pr9.0000000000000666
发表时间：
2018-07
期刊：
Pain reports
影响因子：
4.8
作者：
Barney CC;Stibb SM;Merbler AM;Summers RLS;Deshpande S;Krach LE;Symons FJ
通讯作者：
Symons FJ

Can biomarkers differentiate pain and no pain subgroups of nonverbal children with cerebral palsy? A preliminary investigation based on noninvasive saliva sampling.

生物标志物可以区分脑瘫非语言儿童的疼痛和无痛亚组吗？

DOI：
10.1111/pme.12545
发表时间：
2015
期刊：
Pain medicine (Malden, Mass.)
影响因子：
0
作者：
Symons,FrankJ;ElGhazi,Issam;Reilly,BrianG;Barney,ChantelC;Hanson,Leah;Panoskaltsis-Mortari,Angela;Armitage,IanM;Wilcox,GeorgeL
通讯作者：
Wilcox,GeorgeL

Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes.