Psychiatric Characterization/Mild Cognitive Impairment

精神特征/轻度认知障碍

• 批准号: 7007299
• 负责人: Yonas E Geda
• 金额: $ 11.13万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2006-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7007299
• 关键词: Alzheimer' s disease; aging; brain disorder diagnosis; clinical research; cognition disorders; dementia; disease /disorder proneness /risk; human subject; neuropsychological tests; pathologic process; prognosis

DESCRIPTION (provided by applicant): The study of mild cognitive impairment (MCI) is crucial since MCI subjects convert to Alzheimer's Disease (AD) at the rate of 10-15%/year as compared to 1-2% of the general population; indeed, the long term goal of the candidate is to develop a research project dedicated to the prevention of AD by early detection and treatment of psychiatric problems in patients with MCI. In order to achieve this; the candidate needs to have expertise and knowledge in prospective research. The proposed special application of the K01 Award (Scientist Development Award for New Minority Faculty) will address this need via two short term goals: (1) developing expertise in neurodegenerative disorders with a focus on MCI, which is the border zone between normal aging and AD; and (2) developing expertise in prospective research and longitudinal methods by focusing on identifying psychiatric risk factors and their impact in the disease progression of MCI. These two objectives will be met via mentored activities, course work and research. The mentor of the candidate is a Principal Investigator (PI) on AD prevention study targeting MCI involving 70 Alzheimer's Disease Research Centers. The candidate will meet with the mentors regularly throughout the grant period to discuss didactic and research issues. The course work will lead to a MSc degree in clinical research through the Mayo Clinical Research Training Program (MCRTP). The candidate's research plan is innovative because it targets the study of noncognitive variables in MCI. Most subjects with MCI likely manifest the earliest signs of AD. These manifestations not only include cognitive dysfunction, but may also involve neuropsychiatric symptoms as well. In this proposed K award, apathy, anxiety and depression will be longitudinally studied in MCI subjects and age-gender matched controls. The research will be conducted at the Mayo Alzheimer's Disease Research Center. The K award will then be followed by an R01 submission that will focus on the treatment of these symptoms in order to decrease the rate of decline of MCI to AD. In summary, the research project and the educational activities of the K award will lay down the foundation for the candidate to become an independent investigator in the gray zone between aging and dementia.

描述（由申请人提供）：轻度认知障碍 (MCI) 的研究至关重要，因为 MCI 受试者每年转化为阿尔茨海默病 (AD) 的比例为 10-15%，而普通人群的这一比例为 1-2%；事实上，候选人的长期目标是开发一个研究项目，致力于通过早期发现和治疗 MCI 患者的精神问题来预防 AD。为了实现这一目标；候选人需要具备前瞻性研究方面的专业知识和知识。拟议的 K01 奖（新少数族裔教师科学家发展奖）的特殊申请将通过两个短期目标来满足这一需求：（1）发展神经退行性疾病方面的专业知识，重点是 MCI，这是正常衰老和 AD 之间的边界区域； (2) 通过重点确定精神危险因素及其对 MCI 疾病进展的影响，发展前瞻性研究和纵向方法的专业知识。这两个目标将通过指导活动、课程作业和研究来实现。候选人的导师是针对 MCI 的 AD 预防研究的首席研究员 (PI)，涉及 70 个阿尔茨海默病研究中心。候选人将在整个资助期间定期与导师会面，讨论教学和研究问题。该课程将通过梅奥临床研究培训计划 (MCRTP) 获得临床研究硕士学位。该候选人的研究计划具有创新性，因为它的目标是研究 MCI 中的非认知变量。大多数患有 MCI 的受试者可能会表现出 AD 的最早迹象。这些表现不仅包括认知功能障碍，还可能涉及神经精神症状。在拟议的 K 奖中，将在 MCI 受试者和年龄-性别匹配的对照组中纵向研究冷漠、焦虑和抑郁。该研究将在梅奥阿尔茨海默病研究中心进行。 K 奖之后将提交 R01 申请，该申请将重点关注这些症状的治疗，以降低 MCI 向 AD 下降的速度。总而言之，K奖的研究项目和教育活动将为候选人成为衰老和痴呆之间灰色地带的独立研究者奠定基础。