Psychiatric Characterization/Mild Cognitive Impairment

精神特征/轻度认知障碍

• 批准号: 7157575
• 负责人: Yonas E Geda
• 金额: $ 15.83万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157575
• 关键词: Address; Age; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Anxiety; Award; Clinical Research; Dementia; Development; Disease Progression; Early Diagnosis; Educational Activities; Equipment and supply inventories; Faculty; Foundations; Gender; General Population; Goals; Grant; Gray unit of radiation dose; High Prevalence; Impaired cognition; K-Series Research Career Programs; Knowledge; Lead; Measures; Mental Depression; Mentored Research Scientist Development Award; Mentors; Methods; Minority; Multivariate Analysis; Neurodegenerative Disorders; Outcome; Patients; Prevalence; Principal Investigator; Psychiatric therapeutic procedure; Rate; Research; Research Personnel; Research Project Grants; Research Project Summaries; Research Training; Risk Factors; Scientist; Symptoms; Training Programs; Work; functional decline; innovation; mild neurocognitive impairment; neuropsychiatry; normal aging; prospective

DESCRIPTION (provided by applicant): The study of mild cognitive impairment (MCI) is crucial since MCI subjects convert to Alzheimer's Disease (AD) at the rate of 10-15%/year as compared to 1-2% of the general population; indeed, the long term goal of the candidate is to develop a research project dedicated to the prevention of AD by early detection and treatment of psychiatric problems in patients with MCI. In order to achieve this; the candidate needs to have expertise and knowledge in prospective research. The proposed special application of the K01 Award (Scientist Development Award for New Minority Faculty) will address this need via two short term goals: (1) developing expertise in neurodegenerative disorders with a focus on MCI, which is the border zone between normal aging and AD; and (2) developing expertise in prospective research and longitudinal methods by focusing on identifying psychiatric risk factors and their impact in the disease progression of MCI. These two objectives will be met via mentored activities, course work and research. The mentor of the candidate is a Principal Investigator (PI) on AD prevention study targeting MCI involving 70 Alzheimer's Disease Research Centers. The candidate will meet with the mentors regularly throughout the grant period to discuss didactic and research issues. The course work will lead to a MSc degree in clinical research through the Mayo Clinical Research Training Program (MCRTP). The candidate's research plan is innovative because it targets the study of noncognitive variables in MCI. Most subjects with MCI likely manifest the earliest signs of AD. These manifestations not only include cognitive dysfunction, but may also involve neuropsychiatric symptoms as well. In this proposed K award, apathy, anxiety and depression will be longitudinally studied in MCI subjects and age-gender matched controls. The research will be conducted at the Mayo Alzheimer's Disease Research Center. The K award will then be followed by an R01 submission that will focus on the treatment of these symptoms in order to decrease the rate of decline of MCI to AD. In summary, the research project and the educational activities of the K award will lay down the foundation for the candidate to become an independent investigator in the gray zone between aging and dementia.

描述（由申请人提供）：轻度认知障碍（MCI）的研究至关重要，因为MCI受试者以每年10-15%的速度转变为阿尔茨海默病（AD），而普通人群的这一比例为1-2%；事实上，候选人的长期目标是开展一个研究项目，致力于通过早期发现和治疗MCI患者的精神问题来预防AD。为了达到这个目的；候选人需要具备前瞻性研究方面的专业知识和知识。K01奖（新少数民族教师科学家发展奖）的特别申请将通过两个短期目标来解决这一需求：(1)发展神经退行性疾病的专业知识，重点关注MCI，这是正常衰老和AD之间的边界地带；(2)发展前瞻性研究和纵向方法的专业知识，重点确定精神危险因素及其对MCI疾病进展的影响。这两个目标将通过指导活动、课程作业和研究来实现。候选人的导师是70个阿尔茨海默病研究中心针对MCI的AD预防研究的首席研究员（PI）。候选人将在资助期间定期与导师会面，讨论教学和研究问题。该课程将通过梅奥临床研究培训计划（MCRTP）获得临床研究硕士学位。候选人的研究计划具有创新性，因为它针对MCI的非认知变量的研究。大多数轻度认知障碍患者可能表现出AD的早期症状。这些表现不仅包括认知功能障碍，也可能涉及神经精神症状。在这个提议的K奖中，冷漠、焦虑和抑郁将在MCI受试者和年龄性别匹配的对照组中进行纵向研究。这项研究将在梅奥阿尔茨海默病研究中心进行。获得K奖后，将提交R01报告，重点关注这些症状的治疗，以降低MCI向AD的下降速度。综上所述，K奖的研究项目和教育活动将为候选人成为老龄化和痴呆症之间灰色地带的独立研究者奠定基础。