Psychiatric Characterization/Mild Cognitive Impairment

精神特征/轻度认知障碍

• 批准号: 7081116
• 负责人: Yonas E Geda
• 金额: $ 10.1万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7081116
• 关键词: Alzheimer' s disease; aging; brain disorder diagnosis; clinical research; cognition disorders; dementia; disease /disorder proneness /risk; human subject; neuropsychological tests; pathologic process; prognosis

DESCRIPTION (provided by applicant): The study of mild cognitive impairment (MCI) is crucial since MCI subjects convert to Alzheimer's Disease (AD) at the rate of 10-15%/year as compared to 1-2% of the general population; indeed, the long term goal of the candidate is to develop a research project dedicated to the prevention of AD by early detection and treatment of psychiatric problems in patients with MCI. In order to achieve this; the candidate needs to have expertise and knowledge in prospective research. The proposed special application of the K01 Award (Scientist Development Award for New Minority Faculty) will address this need via two short term goals: (1) developing expertise in neurodegenerative disorders with a focus on MCI, which is the border zone between normal aging and AD; and (2) developing expertise in prospective research and longitudinal methods by focusing on identifying psychiatric risk factors and their impact in the disease progression of MCI. These two objectives will be met via mentored activities, course work and research. The mentor of the candidate is a Principal Investigator (PI) on AD prevention study targeting MCI involving 70 Alzheimer's Disease Research Centers. The candidate will meet with the mentors regularly throughout the grant period to discuss didactic and research issues. The course work will lead to a MSc degree in clinical research through the Mayo Clinical Research Training Program (MCRTP). The candidate's research plan is innovative because it targets the study of noncognitive variables in MCI. Most subjects with MCI likely manifest the earliest signs of AD. These manifestations not only include cognitive dysfunction, but may also involve neuropsychiatric symptoms as well. In this proposed K award, apathy, anxiety and depression will be longitudinally studied in MCI subjects and age-gender matched controls. The research will be conducted at the Mayo Alzheimer's Disease Research Center. The K award will then be followed by an R01 submission that will focus on the treatment of these symptoms in order to decrease the rate of decline of MCI to AD. In summary, the research project and the educational activities of the K award will lay down the foundation for the candidate to become an independent investigator in the gray zone between aging and dementia.

描述(由申请人提供)：轻度认知障碍(MCI)的研究至关重要，因为MCI受试者每年以10-15%的速度转化为阿尔茨海默病(AD)，而总人口的比例为1-2%；实际上，候选人的长期目标是开发一个致力于通过早期发现和治疗MCI患者的精神问题来预防AD的研究项目。为了实现这一点，候选人需要在前瞻性研究方面拥有专业知识和知识。K01奖(新少数族裔教师科学家发展奖)的拟议特别应用将通过两个短期目标满足这一需求：(1)发展神经退行性疾病方面的专门知识，重点是MCI，这是正常衰老和AD之间的边界地带；(2)通过重点识别精神风险因素及其在MCI疾病发展中的影响，发展前瞻性研究和纵向方法方面的专门知识。这两个目标将通过辅导活动、课程工作和研究来实现。候选人的导师是AD预防研究的首席调查员(PI)，该研究针对70个阿尔茨海默病研究中心的MCI。候选人将在整个资助期内定期与导师会面，讨论教学和研究问题。该课程将通过梅奥临床研究培训计划(MCRTP)获得临床研究硕士学位。候选人的研究计划是创新的，因为它的目标是研究MCI中的非认知变量。大多数患有MCI的受试者很可能表现出AD的最早迹象。这些表现不仅包括认知功能障碍，还可能涉及神经精神症状。在这项拟议的K奖中，冷漠、焦虑和抑郁将在MCI受试者和年龄性别匹配的对照组中进行纵向研究。这项研究将在梅奥阿尔茨海默病研究中心进行。K奖之后将提交一份R01文件，重点放在这些症状的治疗上，以降低MCI到AD的下降率。综上所述，K奖的研究项目和教育活动将为候选人在老龄化和痴呆症之间的灰色地带成为一名独立研究员奠定基础。