Conference-Pathogenesis of Neuroimmunologic Disease

会议-神经免疫疾病的发病机制

• 批准号: 7225114
• 负责人: ELIEZAR A DAWIDOWICZ
• 金额: $ 2.65万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225114
• 关键词: Address; Animals; Area; Autoimmune Process; Biological; Cell Adhesion Molecules; Cells; Cytokine Signaling; Demyelinating Diseases; Disease; Faculty; Healthcare; Hypothalamic structure; Immune; Immune system; Immunobiology; Immunogenetics; Immunology; Inflammation; Inflammatory; Institution; Knockout Mice; Laboratories; Marines; Mental disorders; Metabolic; Microglia; Modeling; Molecular Genetics; Muscle; Myelin; Nervous system structure; Neurobiology; Neurologic; Neurons; Neuropathogenesis; Numbers; Nutritional; Pathogenesis; Pathology; Patients; Peripheral Nervous System; Physicians; Physiological; Physiology; Regulation; Role; Scientist; Series; Surveys; Techniques; Thinking; Transgenic Organisms; Viral; Virus Diseases; Week; Wood material; base; concept; cytokine; dysmyelination; human disease; lectures; macrophage; nervous system disorder; neuroimmunologic disease; neuroinflammation; neurophysiology; programs; symposium

DESCRIPTION (provided by applicant): This application represents a request for continued support for a short course entitled "Pathogenesis of Neuroimmunological Diseases" offered at the Marine Biological Laboratory, Woods Hole, MA. It is anticipated that the course will be offered every other year for 2007, 2009 and 2011. The course offers a comprehensive survey of current concepts in the pathogenetic mechanisms involved in a series of neurologic and psychiatric diseases, and includes a faculty, numbering about 40, composed of basic scientists and physician scientists with a wide area of expertise. The two-week program of lectures will describe the application of genetic, molecular, and cell physiologic concepts and techniques in current use in immunology and neurophysiology to the analysis of the pathogenesis of the better known neurologic diseases thought to have an immune basis. Lectures in: Basic Neurobiology will cover cells, secreted factors, adhesion molecules, physiology and structure of the nervous system; Immunobiology will address the cells, factors, adhesion molecules and network interactions that characterize the immune system and inflammatory apparatus. The basics of immunogenetics will also be introduced; Immunopathological disease will be introduced by discussing demyelinating disorders, which will be compared and contrasted with dysmyelinations, as well as nutritional and metabolic myelin diseases. Models of human disease and use of transgenic and knockout mice will also be introduced and discussed extensively; Viral neuropathogenesis will consider viral infections; HIV-related neuropathogenesis, cytokine action in the CNS and cytokine signaling to neural cells. This topic will be extended by addressing the roles of macrophages and microglia in CNS HIV-related pathology, with detailed discussion of HIV-associated pathology in the peripheral nervous system, including muscle; Neuroinflammation in other neurological diseases will be introduced with lectures on inflammatory regulation of hypothalamic function, and, conversely on vagal control of inflammation. The sessions will be supplemented by demonstrations of patients with typical neuroimmunologic disease at health care institutions and of relevant viral and autoimmune models in animals

描述（由申请人提供）：本申请请求继续支持马萨诸塞州伍兹霍尔海洋生物实验室提供的题为“神经免疫学疾病发病机制”的短期课程。预计该课程将在2007年、2009年和2011年每隔一年开设一次。本课程提供了一系列涉及神经和精神疾病的发病机制的当前概念的全面调查，包括大约40名教师，由基础科学家和具有广泛专业知识领域的内科科学家组成。为期两周的课程将介绍目前在免疫学和神经生理学中使用的遗传、分子和细胞生理学概念和技术，以分析被认为具有免疫基础的更广为人知的神经系统疾病的发病机制。基础神经生物学课程将涵盖神经系统的细胞、分泌因子、粘附分子、生理和结构；免疫生物学将解决细胞，因子，粘附分子和网络相互作用表征免疫系统和炎症装置。还将介绍免疫遗传学的基础知识；通过讨论脱髓鞘疾病来介绍免疫病理疾病，并将其与脱髓鞘异常以及营养性和代谢性髓鞘疾病进行比较和对比。还将介绍和广泛讨论人类疾病模型以及转基因和基因敲除小鼠的使用；病毒神经发病机制将考虑病毒感染；hiv相关的神经发病机制、细胞因子在中枢神经系统中的作用以及细胞因子向神经细胞的信号传导。该主题将通过解决巨噬细胞和小胶质细胞在中枢神经系统hiv相关病理中的作用来扩展，详细讨论hiv相关病理在周围神经系统，包括肌肉；其他神经系统疾病中的神经炎症将通过下丘脑功能的炎症调节，以及相反的迷走神经对炎症的控制来介绍。会议还将辅以卫生保健机构典型神经免疫疾病患者的演示以及相关的动物病毒和自身免疫模型