Conference--Pathogenesis of Neuroimmunologic Disease

描述(由申请者提供)：本申请书代表继续支持一个名为“疾病的发病机制”的短期课程。 《神经免疫学疾病》由伍兹海洋生物实验室提供 马萨诸塞州霍尔市预计该课程将每隔一年开设一次。 2001年、2003年和2005年。这门课程提供了对当前 致病机制中的概念涉及一系列神经学和 精神疾病，包括一名教员，人数约40人，由 具有广泛专业知识的基础科学家和内科科学家。这个 为期两周的课程将介绍基因的应用， 分子生理学和细胞生理学的概念和技术 以免疫学和神经生理学为基础分析其发病机制 更广为人知的神经系统疾病被认为有免疫基础。 免疫病理机制讲座将涉及：神经抗原和 随着神经系统和免疫系统的细胞组件，它们的基因 控制以及它们之间的相互作用；通过抗原处理和呈递， 与细胞因子、补体、神经内分泌、 和“心理神经免疫学”的关系；以及与病毒在 神经系统的免疫病理紊乱。主要由抗体介导 “自身免疫性”疾病包括：重症肌无力、格林-巴利病、 和副肿瘤性疾病。主要由细胞介导的“自身免疫性”疾病 将包括：急性感染后脑脊髓炎、多发性硬化症和 眼部慢性炎症性疾病、自主神经系统和 肌肉。额外的讲座将涉及持续的病毒感染 神经系统与免疫相关的中枢慢性炎症性疾病 功能障碍，如：HTLV-1相关性脊髓病，进行性多灶性 白质脑病、SSPE、艾滋病的神经系统表现，以及 阿尔茨海默氏症。这些陈述将涉及潜在的机制 疾病过程和病变的形成，以及它们的生理后果。 课程还将辅以典型患者的示范 卫生保健机构的神经免疫性疾病以及相关的病毒和 动物的自身免疫模型。

DESCRIPTION (provided by applicant): This application represents a request for continued support for a short course entitled "Pathogenesis of Neuroimmuno1ogical Diseases" offered at the Marine Biological Laboratory, Woods Hole, MA. It is anticipated that the course will be offered every other year for 2001, 2003 and 2005. The course offers a comprehensive survey of current concepts in the pathogenetic mechanisms involved in a series of neurologic and psychiatric diseases, and includes a faculty, numbering about 40, composed of basic scientists and physician scientists with a wide area of expertise. The two week program of lectures will describe the application of genetic, molecular, and cell physiologic concepts and techniques in current use in immunology and neurophysiology to the analysis of the pathogenesis of the better known neurologic diseases thought to have an immune basis. Lectures in Immunopathologic Mechanisms will deal with: neural antigens and with the cellular components of the nervous and immune systems, their genetic control, and their interactions; with antigen processing and presentation, immunogenesis, and tolerogenesis; with cytokines, complement, neuroendocrine, and "psychoneuroimmunologic" relationships; and with the role of viruses in immunopathologic disorders of the nervous system. Primarily Antibody-Mediated "autoimmune" disorders will include: myasthenia gravis, Guillain Barre disease, and paraneoplastic disorders. Primarily Cell-Mediated 'autoimmune" disorders will include: acute post-infectious encephalomyelitis, multiple sclerosis, and chronic inflammatory diseases of the eye, the autonomic nervous system, and muscle. Additional lectures will deal with Persistent Viral Infections of the nervous system and chronic inflammatory disorders of the CNS related to immune dysfunction, such as: HTLV- 1-associated myelopathy, progressive multifocal leukoencephalopathy, SSPE, nervous system manifestations of AIDS, and Alzheimer's disease. The presentations will deal with mechanisms underlying disease process and lesion formation, and with their physiologic consequences. The sessions will be supplemented by demonstrations of patients with typical neuroimmunologic disease at health care institutions and of relevant viral and autoimmune models in animals.