Development of MR Imaging for Degenerative Disc Disease

退行性椎间盘疾病磁共振成像的发展

• 批准号: 7222079
• 负责人: GABRIELLE JOSEPH
• 金额: $ 3.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7222079
• 关键词: Biochemical; Biochemistry; Cell Nucleus; Clinical; Collagen; Dehydration; Detection; Development; Diagnosis; Diagnostic; Diagnostic radiologic examination; Disease; Disease Progression; Early Diagnosis; Evaluation; Facet joint structure; High Prevalence; Hydration status; Image; Imaging Techniques; Intervertebral disc structure; Invasive; Lead; Low Back Pain; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Patients; Proteoglycan; Relaxation; Specimen; Staging; Techniques; Time; Tissues; X-Ray Computed Tomography; human subject; improved; in vivo; intervertebral disk degeneration; macromolecule; prevent; soft tissue; vertebra body

DESCRIPTION (provided by applicant): Current clinical imaging techniques, including radiography and computed tomography (CT), cannot detect early biochemical degenerative changes in the intervertebral disc. However, magnetic resonance imaging (MRI) has the potential for diagnosis of early intervertebral disc degeneration (IVDD). By identifying biochemical changes that occur in the early stages of IVDD, MRI may enable the detection of IVDD before irreversible morphologic degeneration occurs. Recent studies have proposed that T1rho relaxation time is associated with loss of macromolecules (which is an initiating factor in IVDD). The objective of this proposal is to develop an imaging technique for quantifying T1rho relaxation time in the intervertebral disc, and to utilize this method to investigate IVDD in human subjects with different degrees of disc degeneration. The sensitivity of T1rho will be investigated by evaluating the relationship between T1rho in intervertebral disc specimens and collagen and proteoglycan content. These studies will contribute to the development of a criterion for detecting early stages of disc degeneration, and will advance the overall understanding of how MR relaxation parameters relate to biochemical changes in disease.

描述（由申请人提供）：目前的临床成像技术，包括X线摄影和计算机断层扫描（CT），无法检测椎间盘的早期生化退行性变化。然而，磁共振成像（MRI）具有诊断早期椎间盘退变（IVDD）的潜力。通过识别IVDD早期阶段发生的生化变化，MRI可以在不可逆的形态学变性发生之前检测IVDD。最近的研究表明，T1rho弛豫时间与大分子的损失有关（这是IVDD的起始因素）。本提案的目的是开发一种用于量化椎间盘中T1 rho弛豫时间的成像技术，并利用该方法研究不同程度椎间盘退变的人类受试者的IVDD。将通过评价椎间盘标本中T1 rho与胶原和蛋白多糖含量之间的关系来研究T1 rho的敏感性。这些研究将有助于发展一个标准，用于检测早期阶段的椎间盘退变，并将推进MR弛豫参数如何与疾病的生化变化的整体理解。