MRI T2 Relaxation Time as a Predictor of Osteoarthritis

MRI T2 弛豫时间作为骨关节炎的预测因子

• 批准号: 7912829
• 负责人: GABRIELLE JOSEPH
• 金额: $ 4.66万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7912829
• 关键词: Address; Affect; Biochemical; Biological Markers; Bone Marrow; Cartilage; Cross-Sectional Studies; Degenerative polyarthritis; Detection; Development; Disease; Early Diagnosis; Goals; Incidence; Joints; Knee Osteoarthritis; Knee joint; Link; Magnetic Resonance Imaging; Maps; Meniscus structure of joint; Morphology; Pain; Patients; Relaxation; Risk; Role; Spatial Distribution; Techniques; Time; United States; cohort; longitudinal analysis; novel; prevent; prospective; public health relevance; therapy development

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone. Despite the fact that OA is a widespread and debilitating disease, current treatment options are extremely limited and no established disease-modifying therapies exist. The development of therapies that can prevent the onset OA and halt its progression is contingent upon the discovery of non-invasive biomarkers for early disease detection. While MRI can be used to non-invasively visualize morphologic joint degeneration in OA, recent MRI developments show promise for the detection of early biochemical changes in cartilage, prior to the morphologic degeneration. An advanced MRI technique, called T2 relaxation time mapping, is sensitive to early biochemical changes in cartilage and has the potential for early diagnosis of OA. The proposed study aims to evaluate cartilage T2 relaxation time in subjects who have no pain, but are at risk for the development of OA. Preliminary studies have shown promising results linking the spatial distribution of cartilage T2 to the progression of pain in subjects with OA. The results of the proposed study will be valuable in that they will help determine whether early biochemical changes in cartilage, as quantified by T2 mapping parameters, can predict the onset of symptomatic knee OA. In order to address this topic, the following three specific aims are proposed: Aim 1: Cross-sectional Analysis. To determine the relationship between cartilage biochemical composition as quantified using the mean, spatial distribution, and laminar organization of T2 relaxation time, and morphologic knee joint degeneration in the cartilage, meniscus and bone marrow, in patients from the OAI incidence cohort. Aim 2: Prospective Analysis. To determine whether baseline cartilage biochemical composition can predict the presence of symptomatic knee OA, defined as development of pain and an increase in morphologic degeneration in the cartilage, meniscus, and bone marrow after two years. Aim 3: Longitudinal Analysis. To determine whether changes in cartilage biochemical composition are related to the presence of symptomatic knee OA. PUBLIC HEALTH RELEVANCE: The ultimate goal of this project is to assess the relationship between cartilage biochemical composition, as quantified by novel MRI techniques (specifically T2 mapping), and longitudinal changes in cartilage morphology. Subjects from the Osteoarthritis Initiative (OAI) incidence cohort, who are at risk for developing osteoarthritis, will be investigated. The results of this study will be integral in evaluating the role of MRI T2 as a marker for early cartilage degeneration in osteoarthritis.

描述（由申请人提供）：骨关节炎（OA）是一种退化性关节疾病，仅影响了美国超过2700万人。尽管OA是一种普遍且使人衰弱的疾病，但目前的治疗选择极为有限，没有既定的疾病改良疗法。可以防止OA发作并停止其进展的疗法的发展取决于发现非侵入性生物标志物以进行早期疾病检测。虽然MRI可用于非侵入性地可视化OA中的形态关节变性，但最近的MRI开发显示出在形态变性之前检测到软骨早期生化变化的希望。一种称为T2松弛时间映射的高级MRI技术对软骨的早期生化变化敏感，并且有可能早期诊断OA。拟议的研究旨在评估没有疼痛但有OA发展风险的受试者的软骨T2松弛时间。初步研究表明，有希望的结果将软骨T2的空间分布与OA受试者的疼痛进展有关。拟议的研究的结果将很有价值，因为它们将有助于确定通过T2映射参数量化软骨的早期生化变化是否可以预测有症状的膝关节OA的发作。为了解决此主题，提出了以下三个特定目标：目标1：横截面分析。通过使用OAI发病率组的患者中，使用T2松弛时间的平均分布和层流组织定量的软骨生化组成与T2松弛时间的均值分布和层流组织进行了量化的关系。目标2：前瞻性分析。为了确定基线软骨生化成分是否可以预测有症状的膝关节OA的存在，定义为疼痛的发展和两年后软骨，半月板和骨髓中形态变性的增加。目标3：纵向分析。确定软骨生化组成的变化是否与有症状的膝关节OA有关。 公共卫生相关性：该项目的最终目标是评估软骨生化组成之间的关系，该关系通过新颖的MRI技术（特别是T2映射）量化，以及软骨形态的纵向变化。将研究来自骨关节炎倡议（OAI）发病率的受试者，患有患骨关节炎的风险。这项研究的结果将在评估MRI T2作为骨关节炎早期软骨变性的作用方面是不可或缺的。