ARTERIAL ENDOTHELIAL FUNCTION--AN EPIDEMIOLOGIC STUDY

动脉内皮功能——流行病学研究

• 批准号: 7258781
• 负责人: TRUDY L BURNS
• 金额: $ 73.72万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-15 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7258781
• 关键词: Adhesions; Adult; Affect; Age; Age-Years; Aging; Animals; Apolipoprotein E; Apolipoproteins B; Arterial Fatty Streak; Arteries; Atherosclerosis; Bile Acids; Blood Platelets; Blood Pressure; Blood Vessels; Blood coagulation; Body Size; Calcium; Cardiovascular Diseases; Carotid Arteries; Carotid Artery Diseases; Carotid Stenosis; Child; Childhood; Cholesterol; Coronary; Coronary artery; Coronary heart disease; Development; Diabetes Mellitus; Dilatation - action; Disease; Disease regression; Elderly; Electron Beam Tomography; Endothelial Cells; Enzymes; Epidemiologic Studies; Female; Folate; Functional disorder; Future; Generations; Genetic; Genotype; Grant; High Density Lipoprotein Cholesterol; Homocysteine; Homocystine; Homozygote; Human; Hyperhomocysteinemia; In Vitro; Individual; Inflammation; Intervention; Intervention Trial; Investigation; LDL Cholesterol Lipoproteins; Lesion; Life; Lipids; Lipoprotein (a); Low-Density Lipoproteins; Measurement; Measures; Medial; Mediating; Mediator of activation protein; Metabolic; Metabolism; Methylenetetrahydrofolate reductase (NADPH); Monkeys; Mutation; Oxidants; Particle Size; Pathogenesis; Pathological Dilatation; Plasma; Platelet aggregation; Play; Population; Predictive Value; Process; Process Measure; Production; Property; Risk; Risk Factors; Role; Sampling; Smoke; Smoking; Stimulation of Cell Proliferation; Stress; Symptoms; Therapeutic; Therapeutic Intervention; Thick; Time; Triglycerides; Vascular Diseases; Vasodilator Agents; Vasomotor; Vitamin B 12; Vitamin B6; Youth; absorption; apolipoprotein E-4; brachial artery; calcification; carbene; cardiovascular risk factor; cerebrovascular; cohort; coronary artery calcification; design; experience; hypercholesterolemia; improved; lipid transport; macrophage; male; monocyte; oxidation; oxidized low density lipoprotein; particle; response; shear stress; thermostability; young adult

Many young adult subjects have some degree of atherosclerotic coronary and carotid artery disease and experience no symptoms. As time passes, many die suddenly and unexpectedly and only limited therapeutic options are available once symptomatic coronary heart disease and stoke occur. Since the atherosclerotic process begins in youth, a measure of the early manifestations of atheroscleosis may have the potential of identifying subjects at risk for premature coronary and carotid occlusive vascular disease when therapeutic options can be administered. Impaired brachial artery flow mediated dilatory (FMD) capacities have been shown to exist in children and young adults with hypercholesterolemia, hyperhomocysteinemia, diabetes and in those who smoke. Impaired brachial artery FMD has been shown to relate to impaired endothelial function, which is an early manifestation of the atherosclerotic process. If impaired brachial artery FMD is a predictor of the process, then it may be used to non-invasively assess atherosclerosis early in its development and to evaluate the effect of therapeutic interventions. In a cohort of 600 adults, 35 to 43 years of age, from the Muscatine Study, whose risk factors were measured during childhood and young adulthood, we propose to measure contemporaneous risk factors, and brachial artery FMD, along with coronary artery calcification (CAC) and carotid artery intimal-medial thickness (IMT) (the latter two established measures of early atherosclerosis) and again 3 years later. This effort is designed to examine the following hypotheses: 1) Established risk factor levels measured in childhood, adulthood and across the years from childhood through adulthood are predictive of brachial artery FMD; 2) Putative risk factor levels measured in adulthood are related to the degree of brachial artery FMD, CAC and carotid artery IMT; 3) Brachial artery FMD, CAC and carotid artery IMT are related in adults; and 4) Brachial artery FMD is predictive of increased carotid artery IMT. This application is a revision of one previously submitted as a supplement to another grant.

许多年轻的成年受试者患有一定程度的动脉粥样硬化性冠状动脉和颈动脉疾病，并且 没有任何症状。随着时间的推移，许多人突然、意外地死亡，并且只能得到有限的治疗 一旦出现症状性冠心病和中风，就有可用的选择。由于动脉粥样硬化 该过程从青年时期开始，对动脉粥样硬化早期表现的测量可能具有以下潜力： 识别治疗时有早发冠状动脉和颈动脉闭塞性血管疾病风险的受试者 可以管理选项。肱动脉血流介导的扩张（FMD）能力受损 研究表明，存在于患有高胆固醇血症、高同型半胱氨酸血症、糖尿病和糖尿病的儿童和年轻人中。 在那些吸烟的人中。肱动脉 FMD 受损已被证明与内皮功能受损有关， 这是动脉粥样硬化过程的早期表现。如果肱动脉 FMD 受损是以下疾病的预测因素： 过程，然后它可以用于非侵入性地评估动脉粥样硬化的早期发展，并 评估治疗干预的效果。 马斯卡廷研究对 600 名 35 至 43 岁的成年人进行了队列研究，测量了他们的危险因素 在儿童期和青年期，我们建议测量同期危险因素和肱动脉 动脉 FMD，以及冠状动脉钙化 (CAC) 和颈动脉内膜中层厚度 (IMT) （后两项建立了早期动脉粥样硬化的测量方法），三年后又进行了一次。这项努力的目的是 检验以下假设： 1) 在儿童期、成年期和成年期测量的既定危险因素水平 从童年到成年的各个时期都是肱动脉 FMD 的预测因素； 2) 推定风险 成年期测量的因子水平与肱动脉FMD、CAC和颈动脉的程度相关 IMT； 3）成人肱动脉FMD、CAC和颈动脉IMT相关； 4) 肱动脉 FMD 为 颈动脉 IMT 增加的预测。 该申请是对先前作为另一项资助的补充提交的申请的修订。