The Functional Muscle-Bone Unit in JRA

JRA 中的功能性肌肉骨骼单位

• 批准号: 7257217
• 负责人: JON Michael BURNHAM
• 金额: $ 12.68万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-16 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7257217
• 关键词: Address; Adherence; Adolescent; Adult; Affect; Aging; Arthritis; Arts; Biomechanics; Body Composition; Bone Density; Cachexia; Child; Childhood; Chronic; Chronic Childhood Arthritis; Chronic Disease; Condition; Consensus; Cross-Sectional Studies; Data; Deformity; Development; Diet; Disease; Energy Metabolism; Epidemiology; Exercise Physiology; Failure; Fatty acid glycerol esters; Feasibility Studies; Fellowship; Fracture; Glucocorticoids; Growth; Health; Inflammation; Inflammatory; Joints; Label; Life; Longitudinal Studies; Measurement; Measures; Methods; Minerals; Morbidity - disease rate; Muscle; Muscle function; Musculoskeletal; Nutrition Assessment; Osteoporosis; Pattern; Physical activity; Population; Psychology; Research; Research Methodology; Research Personnel; Rest; Rheumatoid Arthritis; Rheumatology; Risk; Risk Factors; Safety; Skeletal Development; Skeletal system; Skeleton; Structure; Techniques; Testing; Training; United States National Institutes of Health; Water; Weight-Bearing state; X-Ray Computed Tomography; behavior prediction; bone; bone health; bone strength; career; clinical epidemiology; density; disease characteristic; early onset; experience; functional status; illness length; improved; mortality; nutrition; osteoclastogenesis; programs; response; skills; therapy design; vibration; young adult

The candidate is a pediatric rheumatologist with advanced training in clinical epidemiology and a research focus on the musculoskeletal complications of juvenile rheumatoid arthritis (JRA). This application proposes a comprehensive, interdisciplinary program that will provide the candidate with the skills and experience necessary for his development into an independent investigator in pediatric rheumatology and epidemiology. His career development will be guided by an outstanding team of experienced investigators in nutrition, body composition, bone health, epidemiology, exercise physiology, and psychology. His training will include formal coursework in advanced methods in nutritional assessment, behavior prediction, and biostatistical techniques for the analysis of longitudinal data. During his rheumatology fellowship, he conducted a preliminary study of the functional muscle-bone unit in children with JRA, demonstrating substantial deficits in bone density and structure in strong association with decreased muscle mass. The research component described in this application proposes to extend this study to examine longitudinal changes in bone structure and muscle mass, and to identify determinants of cachexia in children with JRA, such as increased resting energy expenditure, inflammation and decreased physical activity. These studies will include advanced research methods, such as quantitative computed tomography to assess bone and muscle, the doubly labeled water technique to assess energy expenditure, and accelerometry to assess physical activity patterns. In addition, the study will incorporate measures of inflammation and regulators of osteoclastogenesis. This proposal includes a pilot and feasibility study to assess the adherence, safety, and efficacy of whole body vibration in children with JRA, an intervention designed to load the skeleton and improve bone mass. Completion of this study will provide the applicant with the data and experience needed to support subsequent independent proposals to improve musculoskeletal health in this high-risk population.

候选人是一名儿科风湿病学家，接受了临床流行病学和研究的高级培训 专注于青少年类风湿关节炎（JRA）的肌肉骨骼并发症。此申请提出 一个全面的跨学科计划，将为候选人提供技能和经验 他发展为儿科流变学和流行病学领域的独立研究者所必需的。 他的职业发展将受到一支杰出的营养研究人员的杰出团队的指导 组成，骨骼健康，流行病学，运动生理学和心理学。他的培训将包括 营养评估，行为预测和生物统计学的高级方法中的正式课程 纵向数据分析的技术。在他的风湿病学研究金期间，他进行了一次 JRA儿童的功能性肌肉骨单位的初步研究，证明了大量缺陷 在骨密度和结构中，与肌肉质量降低相关。研究组成部分 在本申请中描述的是扩展这项研究以检查骨结构的纵向变化 和肌肉质量，并确定患有JRA儿童的恶病质的决定因素，例如增加静止 能量消耗，炎症和体育锻炼减少。这些研究将包括高级 研究方法，例如定量计算机断层扫描以评估骨骼和肌肉，双重 标记的水技术评估能量支出和评估体育锻炼的加速度计 模式。此外，该研究将结合炎症和调节剂的措施 破骨细胞生成。该建议包括一项试点和可行性研究，以评估依从性，安全性和 全身振动在JRA儿童中的功效，该干预措施旨在加载骨骼和 改善骨骼质量。这项研究的完成将为申请人提供所需的数据和经验 支持随后的独立建议，以改善这种高危人群中的肌肉骨骼健康。