Functional Muscle-Bone Unit in JRA

JRA 中的功能性肌肉骨骼单元

• 批准号: 6964261
• 负责人: JON Michael BURNHAM
• 金额: $ 14.16万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-16 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6964261
• 关键词: bioenergetics; body composition; body physical activity; bone density; cachexia; children; clinical research; computed axial tomography; diet; epidemiology; human subject; human therapy evaluation; inflammation; juvenile rheumatoid arthritis; longitudinal human study; muscle function; musculoskeletal disorder therapy; musculoskeletal system; nutrition related tag; patient oriented research; photon absorptiometry; sarcopenia

DESCRIPTION (provided by applicant): The candidate is a pediatric rheumatologist with advanced training in clinical epidemiology and a research focus on the musculoskeletal complications of juvenile rheumatoid arthritis (JRA). This application proposes a comprehensive, interdisciplinary program that will provide the candidate with the skills and experience necessary for his development into an independent investigator in pediatric rheumatology and epidemiology. His career development will be guided by an outstanding team of experienced investigators in nutrition, body composition, bone health, epidemiology, exercise physiology, and psychology. His training will include formal coursework in advanced methods in nutritional assessment, behavior prediction, and biostatistical techniques for the analysis of longitudinal data. During his rheumatology fellowship, he conducted a preliminary study of the functional muscle-bone unit in children with JRA, demonstrating substantial deficits in bone density and structure in strong association with decreased muscle mass. The research component described in this application proposes to extend this study to examine longitudinal changes in bone structure and muscle mass, and to identify determinants of cachexia in children with JRA, such as increased resting energy expenditure, inflammation and decreased physical activity. These studies will include advanced research methods, such as quantitative computed tomography to assess bone and muscle, the doubly labeled water technique to assess energy expenditure, and accelerometry to assess physical activity patterns. In addition, the study will incorporate measures of inflammation and regulators of osteoclastogenesis. This proposal includes a pilot and feasibility study to assess the adherence, safety, and efficacy of whole body vibration in children with JRA, an intervention designed to load the skeleton and improve bone mass. Completion of this study will provide the applicant with the data and experience needed to support subsequent independent proposals to improve musculoskeletal health in this high-risk population.

描述（由申请人提供）： 该候选人是一名儿科流变学家，对临床流行病学进行了高级培训，研究重点是少年类风湿关节炎（JRA）的肌肉骨骼并发症。该申请提出了一项全面的跨学科计划，该计划将为候选人提供发展为儿科流变学和流行病学独立研究者所必需的技能和经验。他的职业发展将由一支杰出的营养，身体组成，骨骼健康，流行病学，运动生理学和心理学的经验丰富的调查员团队指导。他的培训将包括用于营养评估，行为预测和生物统计学技术的高级方法的正式课程，以分析纵向数据。在他的风湿病学研究金期间，他对JRA儿童进行了功能性肌肉单位的初步研究，表明骨密度和结构的大量缺陷与肌肉质量降低有很强的联系。本应用中描述的研究组成部分建议扩展这项研究，以检查骨结构和肌肉质量的纵向变化，并确定JRA儿童的恶病质决定因素，例如增加的静息能量消耗，炎症和体育活动减少。这些研究将包括先进的研究方法，例如定量计算机断层扫描，以评估骨骼和肌肉，双重标记的水技术来评估能量消耗，并加速测定法以评估体育锻炼模式。此外，该研究将结合炎症和破骨细胞生成的调节剂的测量。该建议包括一项试验性和可行性研究，以评估JRA儿童全身振动的依从性，安全性和功效，这是一种旨在加载骨骼并改善骨骼质量的干预措施。这项研究的完成将为申请人提供支持后续独立建议所需的数据和经验，以改善此高风险人群中的肌肉骨骼健康。