HIV Outcomes Research and Training in Uganda

描述（由申请人提供）： 此应用程序是在以患者为导向的研究（K-24）的中期职业生涯研究者奖。我在这个奖项的目标是：1）在资源贫乏的环境中提高研究生产力，2）有前途的撒哈拉以南非洲学生，医务人员，研究员和初级教师在设计，执行和出版成果相关的指导资源贫乏的环境研究。迄今为止，我的研究主要集中在旧金山弗朗西斯科贫困的HIV+吸毒者的依从性和健康结果。这包括NIMH资助的关于不完全依从性生物学的研究（NIMH 54907），直接观察抑郁症治疗以改善抑郁症和无家可归者的艾滋病毒治疗结果（NIMH 63011）以及改良直接观察治疗与依从性病例管理的比较（NIMH 64388）。该国内项目已确定9名初级研究者，他们共同发表了7篇第一作者出版物。最近，我把研究项目扩展到了乌干达。在NIAAA的R-21试点资助下，我们正在研究非专利抗逆转录病毒治疗的依从性、药代动力学和耐药性（NIAAA 014784）。这个不断扩大的国际研究项目还确定了4名有才华的初级研究人员（2名乌干达和2名美国研究人员），其中2份手稿已被接受出版，另外2份正在审查中。K-24机制非常适合创造足够的保护时间来扩大这一国际研究计划，并提供直接的 这些有前途的研究人员的指导。我与乌干达马凯雷雷大学建立的关系和支持可能会导致另外几个有前途的国际调查人员。 此外，扩大国际艾滋病毒研究和指导的目标是我的家乡机构的优先事项;我从我的家乡机构的支持承诺，以减少我的临床和行政责任，以实现这一目标的20%。

DESCRIPTION (provided by applicant): This application is for a Mid-Career Investigator Award in Patient-Oriented Research (K-24). My goals in this award are to: 1) Increase research productivity in a resource poor setting and 2) Directed mentorship of promising sub-Saharan African students, medical officers, fellows and junior faculty in designing, executing, and publishing outcomes research relevant to resource-poor settings. My research to date has focused on adherence and health outcomes in impoverished HIV+ drug users in San Francisco. This has included NIMH-funded research on the biology of incomplete adherence (NIMH 54907), Directly Observed Depression Treatment to improve depression and HIV treatment outcomes in depressed homeless individuals (NIMH 63011) and a comparison of Modified Directly Observed Therapy vs. Adherence Case Management (NIMH 64388). This domestic program has identified 9 junior investigators who have collectively published 7 first author publications. More recently, I have expanded my research program to Uganda. With pilot R-21 funding from the NIAAA, we are studying adherence, pharmacokinetics and resistance to generic antiretroviral therapy (NIAAA 014784). This expanding international research program has also identified 4 talented junior investigators (2 Ugandan and 2 US investigators) with 2 manuscripts accepted for publication and an additional two in review. The K-24 mechanism is ideally suited to create sufficient protected time to expand this international research program and to provide directed mentorship of these promising investigators. My established relationship with and support of Makerere University in Uganda likely will lead to several additional promising international investigators. Furthermore, this directed goal of expanding international HIV research and mentorship is a priority for my home institution; I have the supportive commitment from my home institution to reduce my clinical and administrative responsibilities to 20% in order to achieve this goal.