HIV Outcomes Research and Training in Uganda

乌干达的艾滋病毒结果研究和培训

• 批准号: 6952288
• 负责人: DAVID Roy BANGSBERG
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-27 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952288
• 关键词: AIDS; AIDS therapy; Africa; HIV infections; alcoholism /alcohol abuse; antiAIDS agent; antiviral agents; behavioral /social science research tag; clinical research; data collection methodology /evaluation; disease /therapy duration; drug interactions; drug resistance; health behavior; human immunodeficiency virus; human subject; human therapy evaluation; interview; longitudinal human study; outcomes research; patient oriented research; pharmacokinetics; phlebotomy; therapy compliance; training

DESCRIPTION (provided by applicant): This application is for a Mid-Career Investigator Award in Patient-Oriented Research (K-24). My goals in this award are to: 1) Increase research productivity in a resource poor setting and 2) Directed mentorship of promising sub-Saharan African students, medical officers, fellows and junior faculty in designing, executing, and publishing outcomes research relevant to resource-poor settings. My research to date has focused on adherence and health outcomes in impoverished HIV+ drug users in San Francisco. This has included NIMH-funded research on the biology of incomplete adherence (NIMH 54907), Directly Observed Depression Treatment to improve depression and HIV treatment outcomes in depressed homeless individuals (NIMH 63011) and a comparison of Modified Directly Observed Therapy vs. Adherence Case Management (NIMH 64388). This domestic program has identified 9 junior investigators who have collectively published 7 first author publications. More recently, I have expanded my research program to Uganda. With pilot R-21 funding from the NIAAA, we are studying adherence, pharmacokinetics and resistance to generic antiretroviral therapy (NIAAA 014784). This expanding international research program has also identified 4 talented junior investigators (2 Ugandan and 2 US investigators) with 2 manuscripts accepted for publication and an additional two in review. The K-24 mechanism is ideally suited to create sufficient protected time to expand this international research program and to provide directed mentorship of these promising investigators. My established relationship with and support of Makerere University in Uganda likely will lead to several additional promising international investigators. Furthermore, this directed goal of expanding international HIV research and mentorship is a priority for my home institution; I have the supportive commitment from my home institution to reduce my clinical and administrative responsibilities to 20% in order to achieve this goal.

描述(由申请者提供)：本申请是关于以病人为中心的研究(K-24)职业中期研究人员奖的申请。我在这个奖项中的目标是：1)在资源匮乏的环境下提高研究效率，2)指导有前途的撒哈拉以南非洲学生、医务人员、研究员和初级教员设计、执行和发表与资源匮乏环境相关的研究成果。到目前为止，我的研究重点是旧金山贫困的艾滋病毒+吸毒者的依从性和健康结果。这包括由国立卫生研究院资助的关于不完全坚持的生物学的研究(54907)，直接观察抑郁症治疗以改善抑郁无家可归者的抑郁和艾滋病毒治疗结果(63011)，以及改良直接观察疗法与坚持病例管理的比较(64388)。这一国内项目确定了9名初级调查人员，他们总共发表了7篇第一作者出版物。最近，我把我的研究项目扩展到了乌干达。在NIAAA的R-21试点资助下，我们正在研究非专利抗逆转录病毒疗法的依从性、药代动力学和耐药性(NIAAA 014784)。这一不断扩大的国际研究计划还确定了4名有才华的初级调查人员(2名乌干达调查人员和2名美国调查人员)，2份手稿已接受出版，另外2份正在审查中。K-24机制非常适合创造足够的保护时间来扩大这一国际研究计划，并为这些有前途的研究人员提供指导指导。我与乌干达Makerere大学建立的关系和对该大学的支持可能会导致更多有前途的国际调查人员。 此外，扩大国际艾滋病毒研究和指导的这一定向目标是我所在机构的优先事项；我所在机构的支持承诺将我的临床和管理责任减少到20%，以实现这一目标。