HIV Outcomes Research and Training in Uganda

乌干达的艾滋病毒结果研究和培训

• 批准号: 7485756
• 负责人: DAVID Roy BANGSBERG
• 金额: $ 13.69万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-27 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485756
• 关键词: Adherence; Africa; Africa South of the Sahara; African; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Anti-Retroviral Agents; Antiretroviral drug resistance; Award; Beer; Behavior; Biology; Cameroon; Case Management; Central African Republic; Child; Clinical; Communication; Congo; Consumption; Contracts; Country; Data; Dependence; Depressed mood; Development; Directly Observed Therapy; Disruption; Drug Exposure; Drug Kinetics; Drug resistance; Drug user; Economics; Elderly; Faculty; Funding; Gabon; Generic Drugs; Ghana; Goals; HIV; Hand; Health; Home environment; Homelessness; Household; Individual; Institution; International; Interruption; Intoxication; Ivory Coast; Kenya; Lead; Legal; Life; Manuscripts; Marriage; Measurement; Measures; Mediating; Medical Students; Mental Depression; Mentorship; Metabolism; Names; Namibia; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Nigeria; Outcome; Outcomes Research; Patients; Pharmaceutical Preparations; Pilot Projects; Principal Investigator; Process; Production; Productivity; Publications; Publishing; Recruitment Activity; Religion and Spirituality; Research; Research Personnel; Research Training; Resistance; Resistance development; Resources; San Francisco; Slave; South Africa; Substance of Abuse; System; Thinking; Time; Treatment outcome; Uganda; Universities; Urbanization; Viral; Woman; antiretroviral therapy; career; cost; design; distilled alcoholic beverage; drinking; improved; male; man; men; patient oriented research; programs; rural area; social; treatment duration

DESCRIPTION (provided by applicant): This application is for a Mid-Career Investigator Award in Patient-Oriented Research (K-24). My goals in this award are to: 1) Increase research productivity in a resource poor setting and 2) Directed mentorship of promising sub-Saharan African students, medical officers, fellows and junior faculty in designing, executing, and publishing outcomes research relevant to resource-poor settings. My research to date has focused on adherence and health outcomes in impoverished HIV+ drug users in San Francisco. This has included NIMH-funded research on the biology of incomplete adherence (NIMH 54907), Directly Observed Depression Treatment to improve depression and HIV treatment outcomes in depressed homeless individuals (NIMH 63011) and a comparison of Modified Directly Observed Therapy vs. Adherence Case Management (NIMH 64388). This domestic program has identified 9 junior investigators who have collectively published 7 first author publications. More recently, I have expanded my research program to Uganda. With pilot R-21 funding from the NIAAA, we are studying adherence, pharmacokinetics and resistance to generic antiretroviral therapy (NIAAA 014784). This expanding international research program has also identified 4 talented junior investigators (2 Ugandan and 2 US investigators) with 2 manuscripts accepted for publication and an additional two in review. The K-24 mechanism is ideally suited to create sufficient protected time to expand this international research program and to provide directed mentorship of these promising investigators. My established relationship with and support of Makerere University in Uganda likely will lead to several additional promising international investigators. Furthermore, this directed goal of expanding international HIV research and mentorship is a priority for my home institution; I have the supportive commitment from my home institution to reduce my clinical and administrative responsibilities to 20% in order to achieve this goal.

描述（由申请人提供）：本申请是面向患者研究（K-24）的中期职业研究者奖。我在这个奖项中的目标是：1)在资源匮乏的环境中提高研究效率；2)指导有前途的撒哈拉以南非洲学生、医务人员、研究员和初级教师设计、执行和发表与资源匮乏环境相关的研究成果。到目前为止，我的研究主要集中在旧金山贫困的艾滋病毒+吸毒者的依从性和健康结果。这包括NIMH资助的关于不完全依从性生物学的研究（NIMH 54907），直接观察抑郁症治疗以改善抑郁无家可归者的抑郁症和艾滋病毒治疗结果（NIMH 63011），以及改良直接观察治疗与依从性病例管理的比较（NIMH 64388）。该国内项目已确定9名初级研究人员，共发表了7篇第一作者论文。最近，我把我的研究项目扩展到了乌干达。在NIAAA的试点R-21资助下，我们正在研究对非专利抗逆转录病毒治疗的依从性、药代动力学和耐药性（NIAAA 014784）。这个不断扩大的国际研究项目还确定了4名有才华的初级研究人员（2名乌干达和2名美国研究人员），其中2篇手稿已被接受发表，另外2篇正在审查中。K-24机制非常适合于创造足够的保护时间来扩大这一国际研究计划，并为这些有前途的研究人员提供直接指导。我与乌干达Makerere大学建立的关系和对它的支持可能会导致另外几名有前途的国际研究人员。

项目成果

100% adherence study: educational workshops vs. video sessions to improve adherence among ART-naive patients in Salvador, Brazil.

100%%20依从性%20研究：%20教育%20研讨会%20vs.%20视频%20会话%20至%20改善%20依从性%20其中%20ART-naive%20患者%20in%20萨尔瓦多，%20巴西。

• DOI: 10.1007/s10461-008-9414-0
• 发表时间: 2008
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Sampaio-Sa,Marcia;Page-Shafer,Kimberly;Bangsberg,DavidR;Evans,Jennifer;Dourado,MariadeLourdes;Teixeira,Celia;Netto,EduardoM;Brites,Carlos
• 通讯作者: Brites,Carlos

Health information seeking among Mbararan adolescents: results from the Uganda Media and You survey.

姆巴拉兰青少年寻求健康信息：乌干达媒体与你调查的结果。

• DOI: 10.1093/her/cym026
• 发表时间: 2008
• 期刊: Health education research
• 影响因子: 2.4
• 作者: Ybarra,MicheleL;Emenyonu,Nneka;Nansera,Denis;Kiwanuka,Julius;Bangsberg,DavidR
• 通讯作者: Bangsberg,DavidR

Food insufficiency is associated with high-risk sexual behavior among women in Botswana and Swaziland.

• DOI: 10.1371/journal.pmed.0040260
• 发表时间: 2007-10
• 期刊: PLoS medicine
• 影响因子: 15.8
• 作者: Weiser SD;Leiter K;Bangsberg DR;Butler LM;Percy-de Korte F;Hlanze Z;Phaladze N;Iacopino V;Heisler M
• 通讯作者: Heisler M

A qualitative analysis of factors influencing HPV vaccine uptake in Soweto, South Africa among adolescents and their caregivers.

• DOI: 10.1371/journal.pone.0072094
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Katz IT;Nkala B;Dietrich J;Wallace M;Bekker LG;Pollenz K;Bogart LM;Wright AA;Tsai AC;Bangsberg DR;Gray GE
• 通讯作者: Gray GE