Cognitive Sequelae of early and mid-life depression

早中年抑郁症的认知后遗症

• 批准号: 7196487
• 负责人: HOCHANG B LEE
• 金额: $ 16.96万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7196487
• 关键词: Age; Aging; Alleles; Award; Baltimore; Biometry; Catchment Area; Cognitive; Cognitive deficits; Complement; Dementia; Development; Disease; Dysthymic Disorder; Education; Elderly; Enrollment; Epidemiologic Studies; Epidemiology; Functional disorder; Funding; Goals; Health Status; Impaired cognition; Individual; Knowledge; Master' s Degree; Measures; Memory; Memory impairment; Mental Depression; Mental disorders; Mentors; Neuropsychological Tests; Neuropsychology; Numbers; Outcome; Postdoctoral Fellow; Race; Recording of previous events; Research; Research Personnel; Research Project Grants; Research Training; Risk; Sampling; Severities; Testing; Time; aging population; apolipoprotein E-4; career; clinical epidemiology; cohort; depressive symptoms; design; executive function; experience; geriatric depression; instrument; middle age; mild neurocognitive impairment; minor depressive disorder; neuropsychological; programs; sex

DESCRIPTION (provided by applicant): This K23 application will prepare the candidate for an independent research career in the clinical epidemiology of late-life mental disorders. The focus of the research project is to determine the degree to which early and mid-life depressive spectrum disorder increases risk of developing cognitive deficits in later life. Late-life depression has been associated with subsequent development of cognitive deficits in late life,but no previous study has examined the association between early and mid-life depression and later life cognitive deficits. The proposed study provides an unusual, time-sensitive opportunity to test this hypothesis by taking advantage of the recently funded fourth wave of the Baltimore Epidemiologic Catchment Area (ECA) study. Using a retrospective cohort design, the investigator proposes to sample people with depression before age 50 as assessed in previous waves of the Baltimore ECA studies, and examine their neuropsychological outcomes 10 to 23 years later. The specific aims of the proposal are: 1) to determine whether early and mid-life depressive spectrum disorder (before age 50) increases risk of developing Mild Cognitive Impairment or dementia in later life (after age 60), 2) to investigate the longitudinal association between early and mid-life depressive spectrum disorder and late life cognitive deficits in specific neuropsychological domains (i.e. executive function and memory), and 3) to estimate what extent duration, number of episodes, and severity of early and mid-life depressive spectrum disorder predict cognitive impairment in late life. This study will serve as a vehicle for the candidate to obtain invaluable experience in the design and fieldwork of an epidemiologic study of the aging population. To complement his practical research training, the candidate will concurrently enroll in formal courses in Epidemiology and Biostatistics of Aging and fulfill the requirements for a Master's degree. He will participate in seminars in the post-doctoral program in neuropsychology to develop advanced knowledge in use and interpretation of neuropsychological instruments. A panel of mentors and consultants (Drs. Constantine Lyketsos, William Eaton, Jason Brandt, George Rebok, Kung-Yee Liang, George Alexopoulos, and Anand Kumar) will guide his research and training. This award will provide groundwork for his long term goal of becoming an expert in clinical epidemiology of late life mental disorders.

描述（由申请人提供）：此K23应用程序将准备在晚年精神障碍的临床流行病学的独立研究生涯的候选人。该研究项目的重点是确定早期和中期抑郁谱系障碍在多大程度上增加了晚年发展认知缺陷的风险。晚年抑郁症与晚年认知缺陷的后续发展有关，但以前没有研究研究过早期和中期抑郁症与晚年认知缺陷之间的关系。拟议的研究提供了一个不寻常的，时间敏感的机会，以测试这一假设，利用最近资助的第四波巴尔的摩流行病学流域（ECA）的研究。使用回顾性队列设计，研究人员建议对50岁之前患有抑郁症的人进行抽样，如巴尔的摩ECA研究的前几波评估，并检查他们10至23年后的神经心理学结果。该提案的具体目标是：1）确定是否早期和中年抑郁谱系障碍（50岁之前）增加晚年患轻度认知障碍或痴呆症的风险（60岁以后），2）探讨早、中年抑郁谱系障碍与晚年特定神经心理学领域认知缺陷的纵向关联（即执行功能和记忆），以及3）估计早期和中期抑郁谱系障碍的程度持续时间，发作次数和严重程度预测晚年的认知障碍。这项研究将作为候选人获得宝贵的经验，在设计和现场工作的流行病学研究的老龄化人口的工具。为了补充他的实践研究培训，候选人将同时参加流行病学和衰老生物统计学的正式课程，并满足硕士学位的要求。他将参加神经心理学博士后课程的研讨会，以发展神经心理学仪器的使用和解释方面的先进知识。一个由导师和顾问组成的小组（康斯坦丁·莱克索斯、威廉·伊顿、贾森·勃兰特、乔治·雷博克、梁孔义、乔治·亚历山德罗斯和阿南德·库马尔博士）将指导他的研究和培训。该奖项将为他成为晚年精神障碍临床流行病学专家的长期目标奠定基础。