Electron Transport in Tissue-like Material

类组织材料中的电子传输

• 批准号: 7234408
• 负责人: LARRY H TOBUREN
• 金额: $ 20.97万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234408
• 关键词: Accounting; Affect; Apoptosis; Area; Attention; Biochemistry; Biological; Biological Models; Carbon Dioxide; Cells; Characteristics; Charge; Chemicals; Chemistry; Code; Collaborations; Computer Simulation; Data; Databases; Deposition; Development; Dimensions; Dose; Effectiveness; Electron Transport; Electronics; Electrons; Employee Strikes; Equilibrium; Evaluation; Event; Faculty; Film; Freezing; Gases; Genomic Instability; Germany; Goals; Grant; Hydrocarbons; Institutes; Investigation; Ionizing radiation; Ions; Knowledge; Letters; Measurement; Measures; Modeling; Modification; Molecular; Molecular Structure; Object Attachment; Oligonucleotides; Pathway interactions; Pattern; Personal Satisfaction; Phase; Phase Transition; Physics; Play; Potential Energy; Principal Investigator; Probability; Process; Production; Property; Proteins; Protons; Radiation; Radiation Protection; Radiobiology; Range; Reporting; Research; Research Personnel; Role; Screening procedure; Simulate; Solid; Source; Structure; Surface; Technology; Temperature; Testing; Theoretical model; Thick; Tissue Sample; Tissues; Uncertainty; Universities; Water; Work; Xenon; absorption; amorphous solid; base; carcinogenesis; chemical reaction; clinically relevant; cryogenics; design; group cooperation; insight; insulin promoter factor 1; interest; ionization; macromolecule; member; models and simulation; nanometer; nanoscale; particle; physical property; programs; repaired; research study; response; simulation; success

DESCRIPTION (provided by applicant): This proposal is a revised competitive renewal of a three year grant initiated in July, 2002. The proposed study of electron emission from thin foils is designed to provide data to test computational models developed to describe the initial spatial pattern of energy deposition by ionizing radiation in biologic material. These initial damage patterns affect subsequent chemistry and biochemistry that influence crucial cellular pathways leading to biological repair, genomic instability, apoptosis, and/or finally cancer induction. Much of our knowledge of the initial patterns of radiation damage is obtained from event-by-event Monte Carlo track simulation models that often contain uncertainties in their cross section database. The current work, and the proposed extension, provides data on which we can test track simulation models at the level of the physics of electron transport, i.e., prior to modification and averaging by chemical reactions. During the initial grant period data have been obtained for electron transport in water, a major constituent of tissue; SF6, a unique molecule with well defined structure in the low-energy electron transport spectra; and preliminary data have been obtained for several molecules that aid in assessment of effects of surfaces bonding and molecular structure on electron spectra, e.g., data have been derived from solid (frozen) CO2, C2H6, C3H6, C2F2H2, and Xenon. Continuing study of hydrocarbons is underway and target technology is being developed to extend this work to larger bio-molecules and tissue. The cryogenic target provides a unique capability to study bio-molecules and tissue as a function of temperature and thereby as a function of water content. A major goal of the continued work is to better understand the role of water in the transport of electrons in bio- molecules and tissue. We feel this expanded study will provide unique insight into the role of tissue constituents on electron transport, and provide data that can provide sensitive tests of evolving models of electron transport following energy deposition by ionizing radiation. This work will contribute to increased accuracy in the assessment of local dose distributions delivered to cells, cellular components, and critical biomolecules. The results will enhance our effort to establish clinically relevant radiation treatment with a better understanding of potential damage to healthy tissue.

描述（由申请人提供）：本提案是2002年7月启动的三年赠款的修订竞争性续期。拟议的研究从薄箔的电子发射的目的是提供数据，以测试计算模型开发描述的初始空间模式的能量沉积的电离辐射在生物材料。这些初始损伤模式影响随后的化学和生物化学，其影响导致生物修复、基因组不稳定性、细胞凋亡和/或最终癌症诱导的关键细胞途径。我们对辐射损伤的初始模式的了解，大部分是从逐个事件的蒙特卡罗轨迹模拟模型中获得的，这些模型的横截面数据库中往往含有不确定性。目前的工作，以及拟议的扩展，提供了数据，我们可以测试跟踪模拟模型的物理水平的电子传输，即，在通过化学反应改性和平均化之前。在最初的授权期内，已经获得了组织的主要成分水的电子传输数据; SF6，在低能电子传输光谱中具有明确结构的独特分子;以及已经获得了几种分子的初步数据，这些分子有助于评估表面键合和分子结构对电子光谱的影响，例如，数据来源于固态（冷冻）CO2、C2 H6、C3 H6、C2 F2 H2和氙气。碳氢化合物的持续研究正在进行中，目标技术正在开发，以将这项工作扩展到更大的生物分子和组织。低温目标提供了一种独特的能力，研究生物分子和组织作为温度的函数，从而作为水含量的函数。继续工作的一个主要目标是更好地了解水在生物分子和组织中电子传输中的作用。我们认为，这项扩大的研究将提供独特的洞察组织成分对电子传输的作用，并提供数据，可以提供电离辐射能量沉积后的电子传输模型的发展敏感的测试。这项工作将有助于提高评估局部剂量分布传递到细胞，细胞成分和关键生物分子的准确性。这些结果将加强我们建立临床相关放射治疗的努力，更好地了解对健康组织的潜在损害。