CLINICAL CORE

临床核心(核心B)的主要目标将是为GNYARCE研究项目和合作努力提供具有良好特征的自闭症和自闭症谱系障碍受试者和非自闭症对照受试者的队列。核心B将酌情通过诊断评估和评估共病、认知、发育和适应性评估、病史和筛查，以及从自闭症和自闭症谱系受试者以及家庭成员和对照/对照受试者收集遗传样本，获得全面的临床和实验室数据。它将收集一组通用的评估数据，并衡量目标核心症状领域和相关特征 共同的条件，以更好地定义队列。核心将提供基线评估，以评估诊断资格和认知能力，执行功能分析，并确定核心症状的特征，以纳入项目I、II和III。为了实现其目标，核心B将利用三个临床研究站点和一个基因研究站点：西奈山医学院的西弗自闭症研究中心、纽约州立大学石溪分校的科迪自闭症和发育障碍中心、北岸-长岛犹太人健康系统的自闭症中心，以及西奈山的家庭遗传研究计划。

The primary objective of the Clinical Core (Core B) will be to provide a well-characterized cohort of subjects with autism and autism spectrum disorders and non-autistic control subjects for enrollment in GNYARCE research projects and collaborative endeavors. Core B will acquire comprehensive clinical and laboratory data through diagnostic evaluation and assessment of comorbidity, cognitive, developmental, and adaptive assessment, medical history and screening, and genetic sample collection from autistic and autism spectrum subjects as well as family members and control/comparison subjects, as appropriate. It will collect a common set of assessment data and measure target core symptom domains and associated features and comorbid conditions to better define the cohort. The Core will provide baseline evaluation to assess diagnostic eligibility and cognitive ability, perform a functional analysis, and characterize core symptomatology for inclusion in Projects I, II, and III. To accomplish its goals, Core B will utilize three clinical research sites and a genetic research site: the Seaver Autism Research Center at the Mount Sinai School of Medicine, the Cody Center for Autism and Developmental Disabilities at the State University of New York at Stony Brook, the Center for Autism in the North Shore-Long Island Jewish Health System, and the Family Genetic Studies Program at Mount Sinai.