哥伦比亚大学 MLSCN 中心-猫眼课题宝

哥伦比亚大学 MLSCN 中心

批准号：

7499909

负责人：

JAMES ROTHMAN

金额：

$20.13万

依托单位：

COLUMBIA UNIVERSITY HEALTH SCIENCES

依托单位国家：

美国

项目类别：

财政年份：

2005

资助国家：

美国

项目状态：

已结题

起止时间：

2005-07-01 至 2008-06-30

来源：

https://reporter.nih.gov/project-details/7499909

关键词：

Address Adherence Adopted Arts Automation Biological Biological Assay Biology Budgets Capital Cells Cellular biology Chemistry Commit Communities Compatible Complement Computer software Data Data Analyses Databases Decision Making Deposition Development Eels Equipment Exercise Goals Housing Image Image Analysis Informatics Information Systems Intellectual Property Laboratories Lead Leadership Management Information Systems Manuals Molecular Target Numbers Operative Surgical Procedures Other Resources Phase Procedures Proteins Proteomics Protocols documentation Rate Research Research Personnel Resolution Resource Development Resources Right-On Robotics Screening Result Screening procedure Senior Scientist Series Services Sister Specificity Staging Structure System Technology Time TimeLine United States National Institutes of Health Universities Work base cellular imaging computerized data processing data integration design experience functional genomics high throughput screening programs repository small molecule tool vector

期刊论文(6)

专著(0)

科研奖励(0)

会议论文

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.

DOI： 10.1007/s10822-011-9469-2

发表时间： 2011-09

期刊：

Journal of computer-aided molecular design

影响因子： 3.5

作者：

[Vidović D, Xie Y, Rinderspacher A, Deng SX, Landry DW, Chung C, Smith DH, Tautz L, Schürer SC]

通讯作者： Schürer SC

Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.

DOI： 10.1021/jm101004d

发表时间： 2011-01-27

期刊：

Journal of medicinal chemistry

影响因子： 7.3

作者：

[Vang T, Xie Y, Liu WH, Vidović D, Liu Y, Wu S, Smith DH, Rinderspacher A, Chung C, Gong G, Mustelin T, Landry DW, Rickert RC, Schürer SC, Deng SX, Tautz L]

通讯作者： Tautz L

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.

DOI： 10.1016/j.bmcl.2009.01.087

发表时间： 2009-03-15

期刊：

Bioorganic & medicinal chemistry letters

影响因子： 2.7

作者：

[Rinderspacher A, Cremona ML, Liu Y, Deng SX, Xie Y, Gong G, Aulner N, Többen U, Myers K, Chung C, Andersen M, Vidović D, Schürer S, Brandén L, Yamamoto A, Landry DW]

通讯作者： Landry DW

Cell-based assays using primary endothelial cells to study multiple steps in inflammation.

使用原代内皮细胞进行基于细胞的测定来研究炎症的多个步骤。

DOI： 10.1016/s0076-6879(06)14015-x

发表时间： 2006

期刊：

Methods in enzymology

影响因子： --

作者：

[Mayer,Thomas, Jagla,Bernd, Wyler,MichaelR, Kelly,PeterD, Aulner,Nathalie, Beard,Matthew, Barger,Geoffrey, Tobben,Udo, Smith,DeborahH, Branden,Lars, Rothman,JamesE]

通讯作者： Rothman,JamesE

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.

DOI： 10.1016/j.bmcl.2008.03.079

发表时间： 2008-05

期刊：

Bioorganic & medicinal chemistry letters

影响因子： 2.7

作者：

[Yuli Xie;Yidong Liu;G. Gong;A. Rinderspacher;S. Deng;Deborah H. Smith;Udo Toebben;Effie Tzilianos;L. Brandén;D. Vidović;Caty Chung;S. Schürer;L. Tautz;D. Landry]

通讯作者： Yuli Xie;Yidong Liu;G. Gong;A. Rinderspacher;S. Deng;Deborah H. Smith;Udo Toebben;Effie Tzilianos;L. Brandén;D. Vidović;Caty Chung;S. Schürer;L. Tautz;D. Landry