Pathology

病理

基本信息

批准号：
7727027
负责人：
Thomas March
金额：
$ 29.77万
依托单位：
LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7727027
关键词：
Acute Alcian Blue Animal Euthanasia Animals Antigens Area Autopsy Biochemistry Blood Blood Cell Count Body Fluids Bronchoalveolar Lavage Bronchoalveolar Lavage Fluid Canis familiaris Cells Chemistry Chronic Clinical Clinical Pathology Data Detection Economic Inflation End Point Evaluation Fibrosis Freezing Hematology Hematoxylin and Eosin Staining Method Histology Histopathology Human Resources Hyperplasia Hypertrophy Immunohistochemistry In Situ Hybridization Laboratories Liquid substance Lung Messenger RNA Methods Molecular Biology Mucous body substance Mustard Gas Organ Paraffin Embedding Pathogenesis Pathologist Pathology Periodic acid Schiff stain method Preparation Procedures Process Proteomics Pulmonary Emphysema Research Institute Research Project Grants Rodent Safety Scientist Serum Services Slide Specimen Staining method Stains Standards of Weights and Measures Therapeutic Intervention Therapeutic Uses Time Tissue Banks Tissue Fixation Tissues Toxic effect Trichrome stain method United States Food and Drug Administration Urinalysis Work experience lung injury morphometry pressure sample collection sample fixation tissue processing

项目摘要

Specific Aims The Pathology Core will provide service to the research projects outlined by the Center. The Pathology Core for the Center will be the responsibility of personnel in both campuses of the Lovelace Biomedical and Environmental Research Institute (LBERI). Pathology facilities at LBERI are comprised of 3 separate functional areas (Necropsy, Histology, and Clinical Pathology). Each of these produce data or material from which data are derived (e.g., complete blood cell counts, serum chemistry, gross post-mortem findings, histopathology slides and findings) that are analyzed by the pathologists and technicians of the core as well as by scientists outside of the core. The Pathology Core will provide service to studies conducted in all Projects. In any project requiring the euthanasia of animals and subsequent collection of tissue, blood, bronchoalveolar lavage fluid (BALF), and/or other body fluids, the Necropsy Laboratory will be involved. For assessment of toxicity or for identifying targets for therapeutic intervention, Clinical Pathology and Histology services will be used. Specimens collected in these studies may be used in procedures specific to the respective project, but ultimately many specimens collected from Projects 2-5 will also be analyzed for endpoints outlined in Project 1. The Pathology Core will provide service to the Center but will also perform ongoing duties for other studies being conducted by LBERI. Therefore, any or all personnel (including pathologists) within the Necropsy, Clinical Pathology, and Histology Laboratories may be required to work on any given Center project at any given time. A complete description of personnel experience and capabilities follow along with detailed descriptions of the facilities.

具体目标病理核心将为中心概述的研究项目提供服务。这该中心的病理核心将是人员在两个校园中的责任 Lovelace生物医学和环境研究所（Lberi）。 Lberi的病理设施由3个独立的功能区域（尸检，组织学和临床病理学）组成。每个这些产生数据或得出数据的材料（例如，完整的血细胞计数，血清化学，验尸后发现，组织病理学幻灯片和发现）核心的病理学家和技术人员以及核心之外的科学家。病理核心将为所有项目进行的研究提供服务。在任何项目中需要动物安乐死，随后收集组织，血液，支气管肺泡灌洗液（BALF）和/或其他体液，将涉及尸检实验室。为了评估毒性或确定治疗干预，临床病理和将使用组织学服务。这些研究中收集的标本可以用于程序特定于各个项目，但最终从项目2-5收集的许多标本也将对项目1中概述的端点进行分析。病理核心将为中心提供服务但也将对Lberi进行的其他研究履行持续的职责。因此，任何或所有人员（包括病理学家）在尸检，临床病理学和组织学中在任何给定时间，可能要求实验室在任何给定的中心项目上工作。完整人事经验和能力的描述以及详细描述设施。