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Bio-Psych Stress Measure Associations and Preterm Birth

生物心理压力测量协会和早产

基本信息

批准号：
7294918
负责人：
GWEN A LATENDRESSE
金额：
$ 3.47万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-01 至 2008-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): There is compelling evidence that chronic stress contributes to the risk of preterm birth. A proposed mechanism for this contribution is via the maternal-fetal-placental hypothalamic-pituitary-adrenal axes, with corticotropin-releasing hormone (CRH) playing a major regulatory role. The proposed preliminary study of 100 pregnant women has three aims: 1) To identify which aspects of maternal chronic stress have the strongest and most predictive relationships with CRH levels at 15-20 weeks of gestation, using psychometric, behavioral, and demographic indicators of chronic stress, 2) To identify differences in these measures of chronic stress, between categorical splits (i.e. quartiles, tertiles) in CRH levels at 15-20 weeks of gestation, in order to determine if there are relevant groups having potential for stress reduction interventions, and 3) To evaluate the relationships between measures of CRH and chronic stress at 15-20 weeks gestation, and the outcome of term vs. preterm birth, in order to determine which measures might render the greatest predictive value. This preliminary study will lay the groundwork for future investigations of stress reduction interventions having potential to reduce preterm birth. The study will be conducted in conjunction with a longitudinal maternal serum sample collection and storage project, which will be available to the applicant for future biobehavioral research studies.

描述（由申请人提供）：有令人信服的证据表明，慢性压力有助于早产的风险。一个提出的机制，这种贡献是通过母亲-胎儿-胎盘下丘脑-垂体-肾上腺轴，促肾上腺皮质激素释放激素（CRH）发挥主要的调节作用。对100名孕妇进行的初步研究有三个目标：1）使用慢性应激的心理测量、行为和人口统计学指标，确定母体慢性应激的哪些方面与妊娠15-20周时的CRH水平具有最强和最具预测性的关系，2）确定这些慢性应激指标在分类分裂之间的差异（即四分位数，三分位数），以确定是否存在具有压力减轻干预潜力的相关组，以及3）评估妊娠15-20周时CRH和慢性压力的测量值之间的关系，以及足月与早产的结果，以确定哪些措施可能提供最大的预测值。这项初步研究将为未来研究有可能减少早产的减压干预措施奠定基础。本研究将与纵向母体血清样本采集和储存项目一起进行，该项目将提供给申请人用于未来的生物行为研究。