Bio-Psych Stress Measure Associations and Preterm Birth

生物心理压力测量协会和早产

• 批准号: 7156446
• 负责人: GWEN A LATENDRESSE
• 金额: $ 3.47万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156446
• 关键词: birth; clinical research; psychometrics; stress

DESCRIPTION (provided by applicant): There is compelling evidence that chronic stress contributes to the risk of preterm birth. A proposed mechanism for this contribution is via the maternal-fetal-placental hypothalamic-pituitary-adrenal axes, with corticotropin-releasing hormone (CRH) playing a major regulatory role. The proposed preliminary study of 100 pregnant women has three aims: 1) To identify which aspects of maternal chronic stress have the strongest and most predictive relationships with CRH levels at 15-20 weeks of gestation, using psychometric, behavioral, and demographic indicators of chronic stress, 2) To identify differences in these measures of chronic stress, between categorical splits (i.e. quartiles, tertiles) in CRH levels at 15-20 weeks of gestation, in order to determine if there are relevant groups having potential for stress reduction interventions, and 3) To evaluate the relationships between measures of CRH and chronic stress at 15-20 weeks gestation, and the outcome of term vs. preterm birth, in order to determine which measures might render the greatest predictive value. This preliminary study will lay the groundwork for future investigations of stress reduction interventions having potential to reduce preterm birth. The study will be conducted in conjunction with a longitudinal maternal serum sample collection and storage project, which will be available to the applicant for future biobehavioral research studies.

描述（由申请人提供）：有令人信服的证据表明，慢性压力会增加早产的风险。一种提出的机制是通过母体-胎儿-胎盘下丘脑-垂体-肾上腺轴，促肾上腺皮质激素释放激素（CRH）发挥主要的调节作用。这项针对100名孕妇的初步研究有三个目的：1)利用慢性应激的心理测量学、行为学和人口学指标，确定母亲慢性应激的哪些方面与妊娠15-20周CRH水平有最强和最具预测性的关系；2)在妊娠15-20周CRH水平的分类分裂（即四分位数、三分位数）之间，确定这些慢性应激测量的差异，以确定是否有相关群体具有减少应激干预的潜力；3)评估妊娠15-20周CRH与慢性应激、足月与早产结局之间的关系，以确定哪些指标可能具有最大的预测价值。这一初步研究将为未来研究有可能减少早产的减压干预措施奠定基础。该研究将与纵向母体血清样本收集和储存项目一起进行，该项目将为申请人将来的生物行为研究提供支持。