CYP19 & VDR genotypes and bone loss in menopausal women

CYP19

• 批准号: 7244404
• 负责人: KAREN J WHITT
• 金额: $ 3.04万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7244404
• 关键词: Affect; Age; Aging; American; Androgens; Aromatase; Baltimore; Bone Density; CYP19A1 gene; Calcium; Cross-Sectional Studies; DNA; Disease; Enzymes; Estrogen Metabolism; Estrogens; Ethnic Origin; Functional disorder; Genes; Genetic; Genotype; Haplotypes; Health; Health Care Costs; Height; Hormone replacement therapy; Intake; Intervention; Knowledge; Life Style; Longitudinal Studies; Menopausal Status; Menopause; Osteoporosis; Ovarian; Participant; Physical activity; Purpose; Rate; Receptor Gene; Research; Risk; Sampling; Smoking; Symptoms; Time; VDR gene; Vitamin D3 Receptor; Weight; Woman; base; bone; bone loss; dietary control; experience; promoter

DESCRIPTION (provided by applicant): During the menopausal transition, women experience bone loss that can increase the risk of developing osteoporosis. Osteoporosis is a major health issue, as it affects 10 million Americans over age 50 and associated health care costs are $18 billion each year. The genetic basis of osteoporosis is not completely understood. The CYP19 gene and the VDR gene are possible contributors to the pathophysiology associated with bone loss because of their involvement in estrogen metabolism. The purpose of this retrospective, cross-sectional study is to determine if there is a significant difference in bone mineral density and rate of bone loss over a 10-year period according to VDR and CYP19 genotypes and haplotypes in a sample of women from the Baltimore Longitudinal Study on Aging (BLSA) after controlling for dietary and lifestyle factors. CYP19 and VDR genotypes and haplotypes will be evaluated using BLSA DNA samples. Factorial ANCOVA will be used to evaluate differences in BMD and rate of bone loss among subjects according to genotype and haplotype. Findings from this study will increase knowledge about CYP19 & VDR genotypes, BMD, and bone loss in women. Identification of genes that contribute to high rates of bone loss could identify women at risk for osteoporosis prior to symptoms when intervention has the best chance of impacting the health span.

描述（由申请人提供）：在更年期过渡期间，妇女经历骨质流失，可以增加骨质疏松症的风险。骨质疏松症是一个主要的健康问题，因为它影响了50岁以上的1000万美国人，相关的医疗保健费用为每年180亿美元。骨质疏松症的遗传基础尚不完全了解。 CYP19基因和VDR基因可能是导致与骨质流失相关的病理生理学的原因，因为它们参与了雌激素代谢。这项回顾性的，横断面研究的目的是确定根据VDR和CYP19基因型和单倍型的骨矿物质密度和骨质流失率是否存在显着差异，而在控制饮食和生活方式因素后，巴尔的摩纵向研究（BLSA）的妇女样本中是否存在骨骼矿物质密度和骨骼损失。 CYP19和VDR基因型和单倍型将使用BLSA DNA样品进行评估。 阶乘ANCOVA将根据基因型和单倍型评估受试者之间的BMD差异和骨质流失率。这项研究的结果将增加有关女性CYP19和VDR基因型，BMD和骨质流失的知识。当干预措施有最大的机会影响健康范围时，鉴定出高骨质流失率的基因可能会鉴定出骨质疏松症风险的女性。