The role of striosomes in basal ganglia function

描述（由申请人提供）：纹状体具有独特的富含μ阿片受体的细胞簇，称为纹状体，其嵌入在纹状体外基质中。我们的长期目标是确定纹状体在健康和疾病中的作用。具体的假设是，纹状体和它们的输出通路是选择和组织复杂运动序列的功能单位，并且它们的病理有助于亨廷顿病的症状。该假设基于以下报道：（1）在亨廷顿病患者中，纹状体是选择性脆弱的（Hedreen & Folstein，1995），（2）在重复运动期间，纹状体显示出Fos免疫反应性增加（Canales & Graybiel，2000），以及（3）在亨廷顿病小鼠模型中，纹状体体积与复杂运动正相关（Lawhorn et al，2005）。具体目的是：1检验在亨廷顿病小鼠模型中纹状体被选择性损伤的假设，2。通过损伤纹状体中的μ阿片样物质受体簇细胞来确定纹状体是否是执行复杂的测序任务和加速旋转杆任务所必需的，以及3.用2-脱氧葡萄糖放射自显影术测定正常行为动物的纹状体功能相关性。

DESCRIPTION (provided by applicant): The striatum has distinct mu opioid receptor rich clusters of cells called striosomes, which are embedded in an extrastriosomal matrix. Our long term goal is to determine the role of striosomes in health and disease. The specific hypothesis is that striosomes and their output pathways are functional units that select and organize complex movement sequences and their pathology contributes to symptoms of Huntington's disease. The hypothesis is based on reports (1) that striosomes are selectively vulnerable in Huntington's disease patients (Hedreen & Folstein, 1995), (2) striosomes show increase Fos immunoreactivity during repetetive movements (Canales & Graybiel, 2000) and (3) striosome volume postively correlates with a complex movement in a Huntington's disease mouse model (Lawhorn et al, 2005). The specific aims are to: 1 Test the hypothesis that striosomes are selectively damaged in a Huntington's disease mouse model, 2. Determine whether striosomes are necessary to perform a complex sequencing task and an accelerating rotarod task by lesioning the mu opiod receptor clusters of cells in the striatum, and 3. Determine a functional correlate of striosomes using 2-deoxyglucose autoradiography in normal behaving animals.