Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task.
Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task.
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DOI：
10.1016/j.neuroscience.2009.05.021
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发表时间：
2009-09-29
期刊：
影响因子：
3.3
通讯作者：
Brown, L. L.
中科院分区：
文献类型：
--
作者：
Lawhorn, C.;Smith, D. M.;Brown, L. L.
Basal ganglia striosomes, or patches, are rich in mu opioid receptors (MOR) and form a 3-dimiensional labyrinth of cells that extend throughout the mid and anterior striatum in mice. Though previous studies have suggested that striosomes could affect drug-induced motor output in rodents, the functional role of these compartmentalized MOR-rich striosomes is not well understood. To investigate any relationship between the striosomes and motor behavior we used the toxin dermorphin-saporin (DS) to selectively ablate MOR-rich striosomal cells. FVB mice were bilaterally infused with DS in the mid striatum alone or in the mid and anterior striatum, and were tested on three motor tasks and in an open field. Two volume measurement procedures and stereological cell counts were used to confirm the induced pathology. Mice that received DS injections showed significantly smaller volumes (−26 to −44%) and fewer cells (−30 to −49%) in the striosome compartment compared to mice that received control injections of saline or saporin. Striosome pathology was greatest in the dorsolateral striatum. The extrastriosomal matrix was not significantly affected, resulting in an imbalance in the ratio of striosome-to-matrix cells. Behaviorally, toxin injections caused deficits on an accelerating rotarod task and the deficit was worse in mice that received mid and anterior injections than those that received mid striatal injections alone. However, DS-injected mice did not differ from control mice on other motor tasks. We conclude that the MOR-rich cells of the striosomes are necessary for optimal rotarod performance, including learning and/or improvement on the task.
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影响因子：
2.9
作者：
Brooks, Simon P.;Trueman, Rebecca C.;Dunnett, Stephen B.
通讯作者：
Dunnett, Stephen B.
DOI：
10.1097/00005072-199501000-00013
发表时间：
1995-01-01
影响因子：
3.2
作者：
HEDREEN, JC;FOLSTEIN, SE
通讯作者：
FOLSTEIN, SE
DOI：
10.1073/pnas.82.24.8780
发表时间：
1985-12-01
影响因子：
11.1
作者：
GERFEN, CR;BAIMBRIDGE, KG;MILLER, JJ
通讯作者：
MILLER, JJ
影响因子：
8.2
作者：
Choleris, E;Thomas, AW;Prato, FS
通讯作者：
Prato, FS
DOI：
10.1097/00005072-198701000-00002
发表时间：
1987-01-01
影响因子：
3.2
作者：
FERRANTE, RJ;KOWALL, NW;RICHARDSON, EP
通讯作者：
RICHARDSON, EP