Comparison of Exhaled and Serum Nitric Oxide Levels
Comparison of Exhaled and Serum Nitric Oxide Levels
批准号:
7141313
负责人:
JiYeon Choi
金额:
$4.4万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-01-01 至 2008-12-31
关键词:
Acute Lung InjuryAdultAffectAirAnalysis of VarianceAsthmaBiological AssayBloodBreathingCaviaConditionConfounding Factors (Epidemiology)Critical IllnessDevelopmentDiagnosisDisruptionExhalationFellowshipGasesHead and Neck SurgeryHumanIndividualInflammationInpatientsInstructionInvasiveLaryngectomyLungLung TransplantationMeasuresMethodsMonitorNamesNational Research Service AwardsNeuro-Oncological Ventral Antigen 2Nitric OxideNitric Oxide SynthaseNitritesNoseOryctolagus cuniculusOxidative StressOxygenPatientsPatternPneumoniaProcessPurposeRQ2RangeResearchSerumSerum MarkersStagingStandards of Weights and MeasuresTechniquesTechnologyTimeTracheostomy procedureUnited States Food and Drug AdministrationVentilatorWeekage groupairway inflammationcompliance behaviordaydesigninhaled nitric oxideinterestneonateprospectiverespiratoryresponsestatistics
中文摘要
呼出的一氧化氮(NO)作为肺部炎症的非侵入性标志物越来越受到关注
英文摘要
There is a growing interest in exhaled nitric oxide (NO) as a non-invasive marker of pulmonary inflammation
and oxidative stress. Previous studies has focused on use of exhaled NO to diagnose and monitor the airway
inflammation in spontaneously breathing patients, However, few studies have involved mechanically ventilated
(MV) patients. Airway inflammation and oxidative stress during MV tend to predispose to more serious
complications, such as acute lung injury. Thus exhaled NO analysis may also have a potential use in MV
patients. As an initial step, it is necessary to explore changes in levels of exhaled NO and its serum marker
(serum nitrite [sNOa"- ]) over time in patients who require an artificial airway (which disrupts normal NO flow
from the nose to the lower airways) and MV (which introduces confounding factors). The purpose of this study
is to examine changes in exhaled NO from the nose (nNO), exhaled NO from the lower ariways (LNO) and
sNO2~ over time in: 1) spontaneously breathing patients undergoing tracheostomy or laryngectomy (T/L), and
2) patients undergoing tracheostomy while on MV (T-MV). A prospective, 2x3 repeated measures design will
be used. Comparisons will be made between nNO, LNO and sNC>2~ obtained 1) pre-T/L, Day 1-3 post-T/L,
and 1 week after in T/L patients, and 2) pre-tracheostomy, Day 1-3 post-tracheostomy, and 1 week after in
T-MV patients. Statistical analysis will include descriptive statistics, 2x3 repeated measures MANCOVA, one
wav repeated measures ANOVA and Soearman's rank correlation.
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会议论文
Caregivers of Prolonged Mechanical Ventilation: Mind-Body Interaction Model
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批准号:7945296
-
项目类别:
-
资助金额:$3.63万
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财政年份:2009
-
负责人:JiYeon Choi
-
依托单位:
Caregivers of Prolonged Mechanical Ventilation: Mind-Body Interaction Model
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批准号:7673131
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项目类别:
-
资助金额:$4.72万
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财政年份:2009
-
负责人:JiYeon Choi
-
依托单位:
Comparison of Exhaled and Serum Nitric Oxide Levels
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批准号:7056530
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项目类别:
-
资助金额:$4.4万
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财政年份:2006
-
负责人:JiYeon Choi
-
依托单位:
Comparison of Exhaled and Serum Nitric Oxide Levels
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批准号:7334745
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项目类别:
-
资助金额:$1.69万
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财政年份:2006
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负责人:JiYeon Choi
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依托单位:
海外基金