ENDOTHELIAL FUNCTION IN TEENAGE GIRLS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 本研究的目的是证明在有和没有精神病诊断的青春期女孩中测量内皮功能的可行性。 本试验性研究将收集数据，并在2006年10月1日提交的NIH拨款申请的初步研究部分中提供。 该提案中的研究将调查青少年抑郁症或行为障碍是否与心血管疾病（CVD）的危险因素有关，包括内皮功能受损。 CVD是成年女性和男性发病率和死亡率的重要原因。CVD似乎有多种途径，但心血管系统病理学标志物可能早在儿童时期就很明显。 一些研究表明，早期危险因素和CVD之间的中间步骤之一是内皮功能障碍。 某些类型的精神病理学可能会增加CVD的风险。成人研究表明，CVD与抑郁症的发病前病史有关，抑郁症预测预后较差。 这种关联的机制尚不清楚，但下丘脑垂体肾上腺（HPA）轴的过度活跃可能通过代谢综合征的发展发挥作用。反社会行为，如青少年行为障碍，也可能与以后心血管疾病的风险增加，因为HPA轴功能减退。 我们小组和其他人以前的工作已经证明，慢性活动不足与炎症水平升高有关。 长期炎症，表现为C反应蛋白升高等特征，是成人心血管疾病的一个众所周知的风险因素。 如果我们能在更大的研究中证明某些形式的青少年精神病理学与心血管疾病的危险因素有关，这将使我们能够确定一组需要预防工作的青少年。 此外，具有不同类型风险因素的行为表型可能会增加我们对成人心血管疾病多种途径的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. he purpose of this study is to demonstrate the feasibility of measuring endothelial function in adolescent girls with and without psychiatric diagnoses. This pilot study will collect data to present in the Preliminary Studies section of an NIH grant proposal to be submitted on 10/1/06. The study in the proposal will investigate if adolescent depression or conduct disorder is associated with risk factors for cardiovascular disease (CVD), including compromised endothelial function. CVD is a significant cause of morbidity and mortality in adult women and men. There appear to be multiple pathways to CVD, but markers of cardiovascular system pathology may be evident as early as childhood. Several studies have suggested that one of the intermediate steps between early risk factors and CVD is endothelial dysfunction. Certain types of psychopathology may increase the risk for CVD. Adult studies indicate that CVD is associated with a pre-morbid history of depression and that depression predicts a poorer prognosis. The mechanism of this association is not known , but hyperactivity of the hypothalamic pituitary adrenal (HPA) axis is likely to play a role through the development of the metabolic syndrome. Antisocial behavior, such as adolescent conduct disorder may also be associated with increased risk for later cardiovascular disease because of HPA axis hypoactivity. Previous work by our group and others has demonstrated that chronic underactivity is associated with elevated levels of inflammation. Prolonged inflammation, as manifested by characteristics such as elevated C-reactive protein is a well-described risk factor for adult cardiovascular disease. If we can demonstrate that certain forms of adolescent psychopathology are associated with cardiovascular disease risk factors in the larger study, it will enable us to identify a group of teens in need of preventive work. Furthermore, behavioral phenotypes with different types of risk factors may increase our understanding of the multiple paths to adult cardiovascular disease.