ENDOTHELIAL FUNCTION IN TEENAGE GIRLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是论证在有和没有精神疾病诊断的青春期女孩中测量内皮功能的可行性。这项初步研究将收集数据，提交给将于2006年10月1日提交的美国国立卫生研究院拨款提案的初步研究部分。该提案中的研究将调查青少年抑郁或品行障碍是否与心血管疾病(CVD)的风险因素有关，包括内皮功能受损。 心血管疾病是成年男女发病率和死亡率的重要原因。心血管疾病似乎有多种途径，但心血管系统病理的标志可能早在儿童时期就很明显了。一些研究表明，早期危险因素和CVD之间的中间步骤之一是内皮功能障碍。 某些类型的精神病可能会增加患心血管疾病的风险。成人研究表明，心血管疾病与发病前的抑郁症史有关，抑郁症预示着更差的预后。这种联系的机制尚不清楚，但下丘脑-垂体-肾上腺(HPA)轴的过度活动可能通过代谢综合征的发展发挥作用。反社会行为，如青少年行为障碍，也可能与后来由于HPA轴活动不足而增加的心血管疾病风险有关。我们小组和其他人之前的工作已经证明，慢性活动不足与炎症水平升高有关。长期的炎症，如C反应蛋白升高等特征，是成人心血管疾病的一个众所周知的危险因素。 如果我们能够在更大的研究中证明某些形式的青少年精神病理学与心血管疾病风险因素有关，这将使我们能够确定一组需要预防工作的青少年。此外，具有不同类型危险因素的行为表型可能会增加我们对成人心血管疾病的多种途径的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. he purpose of this study is to demonstrate the feasibility of measuring endothelial function in adolescent girls with and without psychiatric diagnoses. This pilot study will collect data to present in the Preliminary Studies section of an NIH grant proposal to be submitted on 10/1/06. The study in the proposal will investigate if adolescent depression or conduct disorder is associated with risk factors for cardiovascular disease (CVD), including compromised endothelial function. CVD is a significant cause of morbidity and mortality in adult women and men. There appear to be multiple pathways to CVD, but markers of cardiovascular system pathology may be evident as early as childhood. Several studies have suggested that one of the intermediate steps between early risk factors and CVD is endothelial dysfunction. Certain types of psychopathology may increase the risk for CVD. Adult studies indicate that CVD is associated with a pre-morbid history of depression and that depression predicts a poorer prognosis. The mechanism of this association is not known , but hyperactivity of the hypothalamic pituitary adrenal (HPA) axis is likely to play a role through the development of the metabolic syndrome. Antisocial behavior, such as adolescent conduct disorder may also be associated with increased risk for later cardiovascular disease because of HPA axis hypoactivity. Previous work by our group and others has demonstrated that chronic underactivity is associated with elevated levels of inflammation. Prolonged inflammation, as manifested by characteristics such as elevated C-reactive protein is a well-described risk factor for adult cardiovascular disease. If we can demonstrate that certain forms of adolescent psychopathology are associated with cardiovascular disease risk factors in the larger study, it will enable us to identify a group of teens in need of preventive work. Furthermore, behavioral phenotypes with different types of risk factors may increase our understanding of the multiple paths to adult cardiovascular disease.