HYPOTHALAMIC PITUITARY ADRENAL AXIS FUNCTION IN ADOLESCENT ANTISOCIAL FEMALES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 通过以下方法描述患有CD的青春期女孩HPA轴的功能，并与没有CD的女孩(NCD)进行比较： A)确定CD女孩在24小时内通过7个唾液样本测量的总的皮质醇活性是否低于NCD女孩；b)调查CD女孩的HPA轴对心理应激的反应，如血浆促肾上腺皮质激素(ACTH)和血清皮质醇水平是否比NCD女孩迟钝；c)确定CD女孩的HPA轴在补充外源性促肾上腺皮质激素释放激素(CRH)时是否会做出与NCD女孩相似的反应；D)评估以下变量对HPA轴功能的影响：不良生活事件暴露、物质使用、睡眠模式、季节、测试前体力活动和心理唤醒以及口服避孕药。如果发现影响，则在分析中对变量(S)进行统计控制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To characterize the function of the HPA axis in adolescent girls with CD and compare it to girls who do not have CD (NCD) by the following methods: a) Determine if overall diurnal cortisol activity, measured by 7 saliva samples during a 24-hour period, is lower in CD than in NCD girls; b) Investigate whether the HPA axis response to psychological stress, as measured by plasma adrenocorticotropin hormone (ACTH) and serum cortisol levels, is blunted in CD girls compared to NCD girls; c) Determine if the HPA axis in CD girls will respond similarly to that of NCD girls when supplied with exogenous corticotropin releasing hormone, (CRH); d) Assess the effects of the following variables on HPA axis function: exposure to adverse life events, use of substances, sleep patterns, season, pre-test physical activity and psychological arousal, and oral contraceptives. If an effect is found, the variable(s) will be statistically controlled in the analyses.