BRAIN MAPPING OF HUNGER AND SATIETY

饥饿和饱腹感的大脑图谱

• 批准号: 7603364
• 负责人: CONSUELO HOPKINS WILKINS
• 金额: $ 0.01万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603364
• 关键词: Biochemical; Brain; Brain Mapping; Cerebrovascular Circulation; Computer Retrieval of Information on Scientific Projects Database; Data; Fasting; Fatty Acids; Fees; Food; Funding; Future; Grant; Hunger; Hyperphagia; Institution; Insulin; Knowledge; Label; Measures; Obesity; Persons; Positron-Emission Tomography; Purpose; Reporting; Research; Research Personnel; Resources; Satiation; Source; Stimulus; United States National Institutes of Health; Water; Weight; design; feeding; relating to nervous system; response; satisfaction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because brain activity has been associated with food stimuli and brain activity differs in the fasted and fed states, studies are not needed to understand differences in brain activity in obese compared to normal weight persons. The neural response may provide important data to understand mechanisms involved in overeating and obesity. The purpose of the pilot proposal is to determine the feasibility of mapping the brain's response to hunger, satiety and satisfaction in obese persons. This study will use 15O labeled water and Positron Emission Tomography (PET) to measure regional cerebral blood flow in persons in the fasted, fed, and fully satiated states. To our knowledge, this study has not been previously reported so this will serve as feasibility data for designing future studies. The study will also allow for correlations between biochemical measures, (including insulin and fee fatty acids) and brain activity.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 由于大脑活动与食物刺激有关，并且大脑活动在禁食和进食状态下不同，因此不需要研究来了解肥胖者与正常体重者相比大脑活动的差异。 神经反应可能为理解暴饮暴食和肥胖的机制提供重要数据。 该试点提案的目的是确定绘制肥胖者大脑对饥饿，饱腹感和满意度的反应的可行性。 本研究将使用15 O标记水和正电子发射断层扫描（PET）来测量禁食、进食和完全饱足状态下的局部脑血流量。 据我们所知，这项研究以前没有报道过，因此这将作为设计未来研究的可行性数据。 该研究还将考虑生化指标（包括胰岛素和脂肪酸）与大脑活动之间的相关性。