BRAIN MAPPING OF HUNGER AND SATIETY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 由于大脑活动一直与食物刺激有关，而禁食和进食状态下的大脑活动不同，因此不需要研究来了解肥胖者与正常体重的人大脑活动的差异。神经反应可能为理解暴饮暴食和肥胖的机制提供重要数据。这项试点计划的目的是确定绘制肥胖者大脑对饥饿、饱腹感和满足感反应图的可行性。 这项研究将使用15O标记水和正电子发射断层扫描(PET)来测量禁食、进食和完全饱和状态下人的局部脑血流量。据我们所知，这项研究以前没有报道过，因此这将作为设计未来研究的可行性数据。这项研究还将考虑生化指标(包括胰岛素和费氏脂肪酸)与大脑活动之间的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because brain activity has been associated with food stimuli and brain activity differs in the fasted and fed states, studies are not needed to understand differences in brain activity in obese compared to normal weight persons. The neural response may provide important data to understand mechanisms involved in overeating and obesity. The purpose of the pilot proposal is to determine the feasibility of mapping the brain's response to hunger, satiety and satisfaction in obese persons. This study will use 15O labeled water and Positron Emission Tomography (PET) to measure regional cerebral blood flow in persons in the fasted, fed, and fully satiated states. To our knowledge, this study has not been previously reported so this will serve as feasibility data for designing future studies. The study will also allow for correlations between biochemical measures, (including insulin and fee fatty acids) and brain activity.