Ophthalmic Optical Coherence Tomography

描述（由申请人提供）：该II期小型企业创新研究申请旨在通过将傅立叶域OCT（FD-OCT）技术商业化并开发用于各种受试者类别的视网膜OCT成像的强大接口，大幅扩展光学相干断层扫描（OCT）技术在临床前人类和动物研究应用中的商业可用性。傅立叶域OCT（FD-OCT）是一种新的创新，与传统的时域OCT（TD-OCT）系统相比，它在灵敏度和鲁棒性方面具有显著的优势。在第一阶段项目中，提出并实现了一种用于视网膜成像的新型扫频光源OCT（SS-OCT）系统，然而系统性能受到830 nm波长的扫频激光组件的可用性的阻碍，导致低功率和低扫频速率。在分包商开发扫频光源830 nm激光器的同时，Bioptigen成功开发了基于光谱域OCT（SD-OCT）的第二台视网膜成像仪。SD-OCT是FD-OCT的替代形式，其中使用宽带光源和光谱仪代替快速扫描激光源。Bioptigen SD-OCT成像仪表现出出色的性能，轴向分辨率为6微米，SNR为106 dB，实时图像更新速率为每秒17张图像（每张图像1000条轴线），软件用户友好。 拟议的第二阶段项目将继续开发我们的高性能SD-OCT视网膜扫描仪系统，增加额外的功能，并将系统从工程测试原型转移到商业系统。我们的研究人员、分包商和顾问团队包括光电元件制造（OCT技术的基础）、光学传感方面的专家，视网膜和眼前节成像OCT系统的原始开发者之一，以及OCT在人类和动物研究应用方面的领先专家。 该提案的具体目标是：1.设计并制造820 nm SD-OCT发动机的生产原型，2.开发高速“OCT眼底”成像，3.构建模块化平台接口，用于人类和研究动物的非接触式成像，4。开发手持式SD-OCT探头，用于人类和研究动物的接触成像; 5.开发并测试OCT视网膜扫描仪的增强型软件套件。

DESCRIPTION (provided by applicant): This Phase II Small Business Innovative Research application proposes to dramatically expand the commercial availability of optical coherence tomography (OCT) technology for pre-clinical human and animal research applications by commercializing Fourier-domain OCT (FD-OCT) technology and developing robust interfaces for retinal OCT imaging in a wide variety of subject classes. Fourier domain OCT (FD-OCT) is a recent innovation which has significant advantages in sensitivity and robustness compared to conventional time-domain OCT (TD-OCT) systems. In the Phase I project, a novel Swept Source OCT (SS-OCT) system for retinal imaging was proposed and implemented, however the system performance was hampered by the availability of swept laser components at the 830nm wavelength, resulting in low power and a slow sweep rate. Simultaneous with development of the swept-source 830nm laser by a subcontractor, a second retinal imager based on Spectral Domain OCT (SD-OCT) was successfully developed at Bioptigen. SD-OCT is an alternative form of FD-OCT, in which a broad band light source and a spectrometer are used in place of a rapidly swept laser source. The Bioptigen SD-OCT imager exhibited outstanding performance, with 6 micrometer axial resolution, 106 dB of SNR at a real-time image update rate of 17 images per second (at 1000 axial lines per image), and user-friendly software. The proposed Phase II project will continue the development of our high-performance SD-OCT retinal scanner system, adding additional functionality and moving the system from an engineering beta prototype to a commercial system. Our team of investigators, subcontractors, and consultants includes experts in optoelectronic component manufacturing (the basis of OCT technology), optical sensing, one of the original developers of OCT systems for retinal and anterior segment imaging, and a leading expert in human and animal research applications of OCT. The specific aims of the proposal are to: 1. Design and build a production prototype 820 nm SD-OCT engine, 2. Develop high speed "OCT Fundus" imaging, 3. Build a modular platform interface for non-contact imaging in humans and research animals, 4. Develop handheld SD-OCT probes for contact imaging in humans and research animals, and 5. Develop and test an enhanced software suite for the OCT retinal scanner.