An Integrated Software Platform for Accelerating Image-Driven Ophthalmic Research and Driving New Insights and Endpoints to the Clinic
一个集成软件平台,用于加速图像驱动的眼科研究并为临床带来新的见解和终点
基本信息
- 批准号:9908389
- 负责人:
- 金额:$ 74.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAge related macular degenerationAlgorithmsArchitectureArtificial IntelligenceAutomobile DrivingBiological MarkersBlindnessClinicClinicalClinical ResearchCollectionCommunicationComputer softwareConsentDataData DiscoveryData ScienceDiabetic RetinopathyDockingEconomicsEnvironmentEye diseasesFoundationsFrustrationFundingGlaucomaGoalsHousingHuman Subject ResearchHybridsImageImaging DeviceImaging technologyInfluentialsInterventionInvestigationKnowledgeLibrariesMosaicismOntologyOphthalmologyOphthalmoscopyOptical Coherence TomographyPatientsPhasePoliciesPrevalenceProcessReaderResearchResearch SubjectsSavingsScienceSiteSmall Business Innovation Research GrantSpeedStrategic PlanningStructureSystemTechnologyTranslatingTranslationsUnited States National Institutes of HealthValidationVisionWisconsinadaptive opticsalgorithm developmentalgorithm trainingapplication programming interfacebiomarker developmentbiomarker discoveryclinical translationcostdata accessdata exchangedata integrationdata sharingdata warehousedeep learningdesignefficacy testingexperiencefightingimage processingimage reconstructionimaging modalityimaging platformimaging programimprovedinnovationinsightmedical schoolsmicrosystemsocular imagingprocess repeatabilityprogramsrepositoryretinal imagingsafety testingsoftware systemsstructured datatoolverification and validationvision science
项目摘要
ABSTRACT
More than 20 million patients suffer from age-related macular degeneration, diabetic retinopathy, or glaucoma. These
degenerative eye diseases develop over decades, and their prevalence is increasing. Retinal imaging technologies such as
optical coherence tomography and adaptive optics ophthalmoscopy are essential tools in the investigation and
management of eye disease. New quantitative biomarkers derived from these and other imaging modalities are critical to
the clinical translation of emerging ophthalmic innovations. However, biomarker development in the era of artificial
intelligence requires large volumes of annotated images and transparent, reproducible processes, which places new
demands on the management of living subjects research, data sharing, and algorithm development. Unfortunately,
current software platforms are not effective in integrating these data in a manner that meets specific requirements in
ophthalmology,
Our goal in this Direct-to-Phase II SBIR, consistent with objectives of the NIH Strategic Plan for Data Science, is to create
an integrated platform (PaaS) for the collection, curation, analysis, and sharing of ocular images and data. We will extend
the capabilities of systems developed by the Advanced Ocular Imaging Program (AOIP), Medical College of Wisconsin
(MCW), which include: (a) LATTICE - a software solution that reduces costs, reduces errors, and improves communications
in the management of living-subjects research; (b) MOSAIC - an image processing platform and algorithm library with
traditional and AI-trained algorithms; and (c) The AOIP Image Bank - a Repository that houses images and data on 1578
fully-consent human research subjects. To create the integrative platform, we will address four aims: (a) Extend LATTICE
to meet the workflow requirements of academic and sponsored research in local and multisite environments, including
the extensible direct integration of data relevant to ocular studies; (b) Design and implement a hybrid (local + cloud)
REPOSITORY architecture, data schema, knowledge ontology, and query architecture for Owners and Readers of data.; (c)
Integrate and demonstrate LATTICE, REPOSITORY and MOSAIC into a continuous ocular science workflow and (d) integrate
and demonstrate Lattice, Repository and Mosaic into a continuous ocular science workflow. Our Integrated Translational
Imaging platform will enable ophthalmic innovators to translate sight-saving insights and interventions to the clinic faster,
with less frustration, and greater confidence.
Our proposal fills an important technology gap in the field of ophthalmic data science and biomarker development. While
the number and type of imaging devices continues to grow, the tools to develop and deploy new biomarkers and clinical
endpoints using these exquisite imaging devices has not kept pace. With this program we will enable a new generation of
image-driven innovation to find its way to the clinic.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Eric L. Buckland其他文献
Eric L. Buckland的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Eric L. Buckland', 18)}}的其他基金
Validating Automated Photoreceptor Analytics Software For Degenerative Eye Disease Research and Biopharma Clinical Trials.
验证用于退行性眼病研究和生物制药临床试验的自动光感受器分析软件。
- 批准号:
9918805 - 财政年份:2020
- 资助金额:
$ 74.33万 - 项目类别:
An Integrated Software Platform for Accelerating Image-Driven Ophthalmic Research and Driving New Insights and Endpoints to the Clinic
一个集成软件平台,用于加速图像驱动的眼科研究并为临床带来新的见解和终点
- 批准号:
10226822 - 财政年份:2020
- 资助金额:
$ 74.33万 - 项目类别:
An Integrated Software Platform for Accelerating Image-Driven Ophthalmic Research and Driving New Insights and Endpoints to the Clinic
一个集成软件平台,用于加速图像驱动的眼科研究并为临床带来新的见解和终点
- 批准号:
10631602 - 财政年份:2020
- 资助金额:
$ 74.33万 - 项目类别:
Choroidal Blood Flow Imaging with Spectral Domain OCT
使用谱域 OCT 进行脉络膜血流成像
- 批准号:
8780425 - 财政年份:2014
- 资助金额:
$ 74.33万 - 项目类别:
Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
用于干眼和角膜诊断的非球面 SDOCT 成像系统
- 批准号:
8394731 - 财政年份:2012
- 资助金额:
$ 74.33万 - 项目类别:
Pediatric Spectral Domain Optical Coherence Tomography
儿科谱域光学相干断层扫描
- 批准号:
8838894 - 财政年份:2009
- 资助金额:
$ 74.33万 - 项目类别:
Pediatric Spectral Domain Optical Coherence Tomography
儿科谱域光学相干断层扫描
- 批准号:
8429508 - 财政年份:2009
- 资助金额:
$ 74.33万 - 项目类别:
Full Range Spectral Domain Anterior Segment OCT Scanner
全范围谱域眼前节 OCT 扫描仪
- 批准号:
7219581 - 财政年份:2007
- 资助金额:
$ 74.33万 - 项目类别:
相似海外基金
I(eye)-SCREEN: A real-world AI-based infrastructure for screening and prediction of progression in age-related macular degeneration (AMD) providing accessible shared care
I(eye)-SCREEN:基于人工智能的现实基础设施,用于筛查和预测年龄相关性黄斑变性 (AMD) 的进展,提供可及的共享护理
- 批准号:
10102692 - 财政年份:2024
- 资助金额:
$ 74.33万 - 项目类别:
EU-Funded
Inhibiting Neovascularization and Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration
抑制新生血管性年龄相关性黄斑变性的新生血管形成和视网膜下纤维化
- 批准号:
10639785 - 财政年份:2023
- 资助金额:
$ 74.33万 - 项目类别:
Inhibition of melanogenesis in retinal pigment epithelium, a contributing factor in age-related macular degeneration
抑制视网膜色素上皮中的黑色素生成,这是年龄相关性黄斑变性的一个促成因素
- 批准号:
23K09052 - 财政年份:2023
- 资助金额:
$ 74.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Deciphering the role of osteopontin in the aging eye and age-related macular degeneration
破译骨桥蛋白在眼睛老化和年龄相关性黄斑变性中的作用
- 批准号:
10679287 - 财政年份:2023
- 资助金额:
$ 74.33万 - 项目类别:
Evaluation of New Anti-inflammatory Treatments for Age-Related Macular Degeneration
年龄相关性黄斑变性的新型抗炎治疗方法的评价
- 批准号:
10642988 - 财政年份:2023
- 资助金额:
$ 74.33万 - 项目类别:
Progression of Early Atrophic Lesions in Age-related Macular degeneration
年龄相关性黄斑变性早期萎缩性病变的进展
- 批准号:
10635325 - 财政年份:2023
- 资助金额:
$ 74.33万 - 项目类别:
Cellular and molecular mechanisms of AIM2 and NLRP3 inflammasome activation in age-related macular degeneration
年龄相关性黄斑变性中 AIM2 和 NLRP3 炎症小体激活的细胞和分子机制
- 批准号:
10584110 - 财政年份:2023
- 资助金额:
$ 74.33万 - 项目类别:
Elucidation of roles of mast cells and macrophages in the pathogenesis of age-related macular degeneration
阐明肥大细胞和巨噬细胞在年龄相关性黄斑变性发病机制中的作用
- 批准号:
22H03243 - 财政年份:2022
- 资助金额:
$ 74.33万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
AMD Mitochondria Modulate Expression of microRNA 135b-5p and 148a-3p in RPE Cybrids: Implications for Age-related Macular Degeneration
AMD 线粒体调节 RPE Cybrids 中 microRNA 135b-5p 和 148a-3p 的表达:对年龄相关性黄斑变性的影响
- 批准号:
10433610 - 财政年份:2022
- 资助金额:
$ 74.33万 - 项目类别:
Targeting the inflammatory response in age-related macular degeneration
针对年龄相关性黄斑变性的炎症反应
- 批准号:
10504138 - 财政年份:2022
- 资助金额:
$ 74.33万 - 项目类别: