An Integrated Software Platform for Accelerating Image-Driven Ophthalmic Research and Driving New Insights and Endpoints to the Clinic

一个集成软件平台,用于加速图像驱动的眼科研究并为临床带来新的见解和终点

基本信息

项目摘要

ABSTRACT More than 20 million patients suffer from age-related macular degeneration, diabetic retinopathy, or glaucoma. These degenerative eye diseases develop over decades, and their prevalence is increasing. Retinal imaging technologies such as optical coherence tomography and adaptive optics ophthalmoscopy are essential tools in the investigation and management of eye disease. New quantitative biomarkers derived from these and other imaging modalities are critical to the clinical translation of emerging ophthalmic innovations. However, biomarker development in the era of artificial intelligence requires large volumes of annotated images and transparent, reproducible processes, which places new demands on the management of living subjects research, data sharing, and algorithm development. Unfortunately, current software platforms are not effective in integrating these data in a manner that meets specific requirements in ophthalmology, Our goal in this Direct-to-Phase II SBIR, consistent with objectives of the NIH Strategic Plan for Data Science, is to create an integrated platform (PaaS) for the collection, curation, analysis, and sharing of ocular images and data. We will extend the capabilities of systems developed by the Advanced Ocular Imaging Program (AOIP), Medical College of Wisconsin (MCW), which include: (a) LATTICE - a software solution that reduces costs, reduces errors, and improves communications in the management of living-subjects research; (b) MOSAIC - an image processing platform and algorithm library with traditional and AI-trained algorithms; and (c) The AOIP Image Bank - a Repository that houses images and data on 1578 fully-consent human research subjects. To create the integrative platform, we will address four aims: (a) Extend LATTICE to meet the workflow requirements of academic and sponsored research in local and multisite environments, including the extensible direct integration of data relevant to ocular studies; (b) Design and implement a hybrid (local + cloud) REPOSITORY architecture, data schema, knowledge ontology, and query architecture for Owners and Readers of data.; (c) Integrate and demonstrate LATTICE, REPOSITORY and MOSAIC into a continuous ocular science workflow and (d) integrate and demonstrate Lattice, Repository and Mosaic into a continuous ocular science workflow. Our Integrated Translational Imaging platform will enable ophthalmic innovators to translate sight-saving insights and interventions to the clinic faster, with less frustration, and greater confidence. Our proposal fills an important technology gap in the field of ophthalmic data science and biomarker development. While the number and type of imaging devices continues to grow, the tools to develop and deploy new biomarkers and clinical endpoints using these exquisite imaging devices has not kept pace. With this program we will enable a new generation of image-driven innovation to find its way to the clinic.
摘要

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Eric L. Buckland其他文献

Eric L. Buckland的其他文献

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{{ truncateString('Eric L. Buckland', 18)}}的其他基金

Validating Automated Photoreceptor Analytics Software For Degenerative Eye Disease Research and Biopharma Clinical Trials.
验证用于退行性眼病研究和生物制药临床试验的自动光感受器分析软件。
  • 批准号:
    9918805
  • 财政年份:
    2020
  • 资助金额:
    $ 74.33万
  • 项目类别:
An Integrated Software Platform for Accelerating Image-Driven Ophthalmic Research and Driving New Insights and Endpoints to the Clinic
一个集成软件平台,用于加速图像驱动的眼科研究并为临床带来新的见解和终点
  • 批准号:
    10226822
  • 财政年份:
    2020
  • 资助金额:
    $ 74.33万
  • 项目类别:
An Integrated Software Platform for Accelerating Image-Driven Ophthalmic Research and Driving New Insights and Endpoints to the Clinic
一个集成软件平台,用于加速图像驱动的眼科研究并为临床带来新的见解和终点
  • 批准号:
    10631602
  • 财政年份:
    2020
  • 资助金额:
    $ 74.33万
  • 项目类别:
Intrasurgical Optical Coherence Tomography
术中光学相干断层扫描
  • 批准号:
    9006007
  • 财政年份:
    2014
  • 资助金额:
    $ 74.33万
  • 项目类别:
Intrasurgical Optical Coherence Tomography
术中光学相干断层扫描
  • 批准号:
    8782159
  • 财政年份:
    2014
  • 资助金额:
    $ 74.33万
  • 项目类别:
Choroidal Blood Flow Imaging with Spectral Domain OCT
使用谱域 OCT 进行脉络膜血流成像
  • 批准号:
    8780425
  • 财政年份:
    2014
  • 资助金额:
    $ 74.33万
  • 项目类别:
Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
用于干眼和角膜诊断的非球面 SDOCT 成像系统
  • 批准号:
    8394731
  • 财政年份:
    2012
  • 资助金额:
    $ 74.33万
  • 项目类别:
Pediatric Spectral Domain Optical Coherence Tomography
儿科谱域光学相干断层扫描
  • 批准号:
    8838894
  • 财政年份:
    2009
  • 资助金额:
    $ 74.33万
  • 项目类别:
Pediatric Spectral Domain Optical Coherence Tomography
儿科谱域光学相干断层扫描
  • 批准号:
    8429508
  • 财政年份:
    2009
  • 资助金额:
    $ 74.33万
  • 项目类别:
Full Range Spectral Domain Anterior Segment OCT Scanner
全范围谱域眼前节 OCT 扫描仪
  • 批准号:
    7219581
  • 财政年份:
    2007
  • 资助金额:
    $ 74.33万
  • 项目类别:

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