Noninvasive real-time total hemoglobin measurement utilizing inexpensive liquid c

利用廉价液体c进行无创实时总血红蛋白测量

• 批准号: 7328381
• 负责人: Alan R Kivnik
• 金额: $ 12.76万
• 依托单位: CORUM MEDICAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-28 至 2009-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7328381
• 关键词: Accident and Emergency department; Age; Anemia; Area; Blood; Blood Tests; Blood Transfusion; Caring; Clinic; Clinical Research; Clinical Trials; Collection; Color; Condition; Coupled; Coupling; Data; Devices; Diagnosis; Diffuse; Encapsulated; Enrollment; Environment; Equipment; Erythrocytes; Ethnic Origin; Eyelid structure; Fiber Optics; Health Personnel; Hematology; Hemoglobin; Hemoglobin concentration result; Hospitals; Image; Individual; Invasive; Island; Light; Lighting; Liquid substance; Marketing; Measurement; Measures; Medical; Medical Device Designs; Methods; Monitor; Operative Surgical Procedures; Oxygen saturation measurement; Patients; Performance; Phase; Physicians; Physiologic pulse; Population; Principal Investigator; Pulse taking; Range; Research; Rhode Island; Screening procedure; Signal Transduction; Solutions; Source; Spectrum Analysis; Structure of palpebral conjunctiva; Tarsal plate; Techniques; Technology; Testing; Time; Transfusion; Universities; Variant; Visible Radiation; Weight; base; concept; conjunctiva; cost; data acquisition; detector; instrumentation; irradiation; liquid crystal; medical specialist; microchip; notch protein; oncology; performance site; programs; sensor; size; voltage

DESCRIPTION (provided by applicant): As a rapid screening technique for anemia, physicians can pull down the lower eyelid and examine the color of the inside lining of the eyelid, called the palpebral conjunctiva. While a qualitative inspection of the palpebral conjunctiva has been shown to be inaccurate in diagnosing anemia, the palpebral conjunctiva is an excellent access point to measure hemoglobin and other blood constituents when analyzed quantitatively using spectroscopy. Using diffuse reflectance spectroscopy, specifically examining the specific visible light absorbance at the palpebral conjunctiva, our team has shown that total hemoglobin levels can be measured noninvasively in a small initial study. The conjunctiva is illuminated with a low power broadband white light source, the diffusely reflected light is collected, and the reflectance signal is analyzed to calculate hemoglobin concentration. While our proof of concept studies on the accuracy of this technique used a commercial grating based spectrometer, liquid crystal (LC) filter technology, one the core competencies of our team, can be used in conjunction with a single photodiode detector to manufacture an ultra-compact and inexpensive microchip spectrometer. The specific configuration of the liquid crystal material to be used, ferroelectric liquid crystal, has shown a full spectrum tunable notch filter with bandwidth <25nm across this regime. Coupling a white LED as an irradiation source into the microchip spectrometer can allow for the fabrication of a fully functional spectroscopic device used to collect the diffuse reflectance spectra from the conjunctiva, calculate hemoglobin concentration, and reliably diagnose anemia. The simplicity of the examination, explicitly pulling down the lower eyelid to expose the palpebral conjunctiva and holding the sensor up to the exposed area to make a measurement, enable this device to be used by a wide array of healthcare providers in numerous environments. The simplicity of this device can enable hemoglobin concentration screening to become a new vital sign in the same fashion the pulse oximeter enabled oxygen saturation measurement. The proposed project here involves (1) the clinical trial of commercial spectroscopic equipment to demonstrate technique accuracy and (2) the clinical trial of fabricated microspectrometer to demonstrate device operation, accuracy, and repeatability compared to commercial instrumentation and invasive blood testing.

描述（由申请人提供）：作为贫血的快速筛查技术，医生可以拉下下眼睑并检查眼睑内衬（称为睑结膜）的颜色。虽然睑结膜的定性检查已被证明在诊断贫血方面不准确，但在使用光谱学进行定量分析时，睑结膜是测量血红蛋白和其他血液成分的绝佳接入点。我们的团队使用漫反射光谱，专门检查睑结膜的特定可见光吸光度，表明可以在一项小型初步研究中非侵入性地测量总血红蛋白水平。用低功率宽带白光源照射结膜，收集漫反射光，分析反射信号以计算血红蛋白浓度。虽然我们对该技术准确性的概念验证研究使用了基于商用光栅的光谱仪，但液晶 (LC) 滤波器技术（我们团队的核心能力之一）可以与单个光电二极管探测器结合使用，以制造超紧凑且廉价的微芯片光谱仪。所使用的液晶材料（铁电液晶）的具体配置已显示出在此范围内带宽<25nm的全光谱可调谐陷波滤波器。将白色 LED 作为照射源耦合到微芯片光谱仪中，可以制造功能齐全的光谱装置，用于收集结膜的漫反射光谱、计算血红蛋白浓度并可靠地诊断贫血。检查简单，明确地拉下下眼睑以暴露睑结膜，并将传感器举到暴露区域进行测量，使得该设备能够被众多环境中的众多医疗保健提供者使用。该设备的简单性可以使血红蛋白浓度筛查成为新的生命体征，就像脉搏血氧计实现氧饱和度测量一样。这里提出的项目涉及（1）商业光谱设备的临床试验，以证明技术准确性；（2）制造的微型光谱仪的临床试验，以证明与商业仪器和侵入性血液检测相比的设备操作、准确性和可重复性。