Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD

描述(由申请人提供)：建议的SBIR计划的总体目标是开发一种新型的生理控制系统，用于旋转离心式MiTiHeartLVAD，该系统采用磁悬浮叶轮和主动/被动混合磁轴承支持系统，其中仅主动控制推力轴承。提出的基本前提是，可用的系统数据集将提供一种自我感知和冗余的方法来控制泵的输出，同时避免与进气口负流量或吸气/汽蚀相关的有害条件。由于进口压力较低，因此作用在转子上的流体力较低，因此预计正常运行的泵和在入口处经历负流动或吸入的泵的运行将不同。通过监测泵的运行参数，将开发出一种新颖可靠的泵速度控制系统，以避免进口吸气/汽蚀和/或负流量。第一阶段项目的目标是通过参数研究论证利用测量的泵参数进行泵控制的可行性，这将导致制定适当的控制方案。第二阶段的目标将是使用已建立的计算机模拟模型来评估控制方案，以改进MiTiHeart LVAD的第一阶段控制算法和控制器。然后，控制器和算法将通过仪表化的非脉动和脉动模拟环路的体外测试来验证。最终的第二阶段验证测试将通过活体动物研究完成。拟建的高速加工中心将由牙医和/或牙科实验室技术人员用于制造陶瓷牙科修复体。拟建的加工中心将采用创新的集成气动、高速、精密、主轴/电机组件设计，以实现高加工速度，同时确保低加工损坏的可能性：从而通过加工快速制造低损伤的牙科修复体。

DESCRIPTION (provided by applicant): The overall objective of the proposed SBIR Program is to develop a novel physiologic control system for use with the rotary centrifugal MiTiHeart LVAD that employs a magnetically suspended impeller with a hybrid active/passive magnetic bearing support system wherein only the thrust bearing is actively controlled. The fundament premise forwarded is that the available system data sets will provide a self-sensing and redundant method of controlling pump output while avoiding the detrimental conditions associated with negative flow or suction/cavitation at the inlet. It is expected that the pump operation will be different for a normally operating pump and one undergoing negative flow or suction at the inlet due to the lower inlet pressure and hence fluid forces acting on the rotor. By monitoring pump operating parameters a novel and reliable pump speed control system will be developed that avoids inlet suction/cavitation and/or negative flow. The goal of Phase I project is to demonstrate the feasibility of using the measured pump parameters for pump control through a parametric study that would lead to the development of the appropriate control scheme. The goal of Phase II will be to evaluate the control scheme using established computer simulation models to refine the Phase I control algorithm and controller for the MiTiHeart LVAD. The controller and algorithm will then be validated through instrumented non-pulsatile and pulsatile mock loop in vitro testing. Final Phase II validation testing will be accomplished through in vivo animal studies. The proposed high-speed machining center will be used by dentists and/or dental laboratory technicians for fabrication of ceramic dental restorations. The proposed machining center will be designed with an innovative integrated air-driven, high-speed, precision, spindle/motor assembly to allow high machining rates while ensuring low potential for machining damage: thus, enabling rapid fabrication of low-damage dental restorations by machining.