Transvaginal probe for fetal magnetocardiography

经阴道胎儿心磁图探头

• 批准号: 7225647
• 负责人: DOUGLAS N PAULSON
• 金额: $ 9.11万
• 依托单位: TRISTAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225647
• 关键词: Abdomen; Animals; Brain; Caliber; Cardiac; Cephalic; Characteristics; Data; Detection; Devices; Electromagnetics; Environment; Event; Fetus; Gestational Age; Goals; Heart; Human; Labor Presentation; Lead; Liquid substance; Magnetism; Measurement; Measures; Mechanics; Noise; Obesity; Patient currently pregnant; Patients; Pattern; Phase; Pregnancy; Property; Reporting; Safety; Scalp structure; Sheep; Signal Transduction; Squid; Standards of Weights and Measures; Surface; Techniques; Technology; Testing; Tissues; Transvaginal Ultrasound; Uterus; Vagina; Week; base; design; fetal; instrument; millimeter; transmission process

DESCRIPTION (provided by applicant): The goal of this project is to develop an instrument for transvaginal fetal cardiac and brain electromagnetic activity at gestations younger than what can be achieved using present technology of transabdomenal fetal signal recording. Recording minute magnetic signals in the fetus is impossible at gestations earlier than 15 weeks using existing technology and is unreliable using standard technology at gestations less than 20-24 weeks, and at any gestation in an obese patient. The proximity of the vagina to the uterus makes this an ideal approach for the obese patient or the early to mid pregnancy. While transvaginal ultrasound has been employed, it alone cannot detect heart conduction abnormalities, because it only assesses mechanical events, and not the electrical events that lead up to the mechanical events. In addition, present technology is large and bulky, generally suspended from a ceiling mount device and covering roughly the diameter of the full-term maternal gravid abdomen. It is anticipated that a transvaginal SQUID probe would obtain signals from fetuses as small as 10- 12 weeks gestation, in conjunction with magnetic shielding. The advantage over present fetal magnetic recording technologies is that it allows more proximate access to the very immature fetus, and unique recording angles, which are superior for signal acquisition. The magnetic signal has been shown to be far superior to the electric signal for fetal cardiac recording due to the characteristics of fetal/maternal tissue and fluid transmission properties.

描述（由申请人提供）：本项目的目标是开发一种仪器，用于在比使用目前的经阴道胎儿信号记录技术所能实现的更年轻的妊娠期进行经阴道胎儿心脏和大脑电磁活动。使用现有技术在小于15周的妊娠中记录胎儿中的微小磁信号是不可能的，并且在小于20-24周的妊娠中以及在肥胖患者的任何妊娠中使用标准技术是不可靠的。阴道与子宫的接近使其成为肥胖患者或妊娠早期至中期的理想方法。虽然已采用经阴道超声，但仅靠它无法检测心脏传导异常，因为它仅评估机械事件，而不是导致机械事件的电事件。此外，目前的技术是大而笨重的，通常从天花板安装装置悬挂并且大致覆盖足月孕妇妊娠腹部的直径。预期经阴道SQUID探针将结合磁屏蔽从小至妊娠10- 12周的胎儿获得信号。与目前的胎儿磁记录技术相比，其优势在于它允许更近距离地接近非常不成熟的胎儿，并具有独特的记录角度，这对于信号采集来说是上级的。由于胎儿/母体组织的特性和流体传输特性，磁信号已被证明远远上级用于胎儿心脏记录的电信号。