SQUID magnetometer detection system for real-time tumor tracking

用于实时肿瘤跟踪的SQUID磁力计检测系统

• 批准号: 7480087
• 负责人: DOUGLAS N PAULSON
• 金额: $ 8.99万
• 依托单位: TRISTAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480087
• 关键词: Accounting; Address; Algorithms; Caliber; Clinical; Compatible; Computational algorithm; Data; Detection; Dimensions; Dose; Frequencies; Goals; Location; Measurement; Measures; Medical Technology; Modality; Modification; Motion; Noise; Normal tissue morphology; Operative Surgical Procedures; Patients; Phase; Physiologic pulse; Positioning Attribute; Prostate; Public Health; Pulse taking; Radiation; Radiation therapy; Radio; Range; Real-Time Systems; Relative (related person); Signal Transduction; Site; Solutions; System; Technology; Testing; Time; Tumor Volume; Uncertainty; Update; Work; base; design; design and construction; detector; magnetic field; meter; prototype; research study; sensor; size; superconducting quantum interference device; tumor; vector

DESCRIPTION (provided by applicant): The goal of radiation therapy is to deliver a curative dose of radiation to the tumor while minimizing the damage to the surrounding normal tissue. Currently, tumor localization is the most significant problem in radiation delivery with respect to achieving curative radiation doses. In order to maximize the delivery dose, the tumor position must be accurately known in both space and time to hit the target during treatment where motion is important. To account for this location uncertainty, tumor dose is delivered to the volume where the tumor might be during treatment. Therefore, the treatment volume and corresponding complications increase with positioning uncertainty. The long term goal of this project is to accurately locate the real-time tumor position during radiation treatment with the following constraints necessary for increasing tumor control: (1) the tumor will be located with real-time tracking where position updates will be acquired within one second; (2) the tumor position will be described in three dimensions relative to a coordinate system defined within the treatment room with an accuracy of less than 1 mm; and (3) the detectors will be extended to ranges that are 2-3 meters or greater. The localization system proposed for this project is made of an (1) implantable, passive transmitter, (2) an external dipole antenna for energizing the transmitter, and (3) a superconducting quantum interference device (SQUID) magnetometer detection system. The energized transmitter will generate a pulsed magnetic field that will be detected by the SQUID sensors which will then be used to locate the transmitter position in real-time. This phase I work of this project will specifically address the detector system design. The goal is to construct a vector magnetometer system that will measure the magnetic field signal at a level of 0.1 pT. In order to detect these extremely low level signals, SQUID magnetometers will be used as the sensors. Even though their sensitivity is large, noise is a major problem that requires specific filtering and design in order to detect these signals. We will design the basic system from measurements and experiments conducted within this project. PUBLIC HEALTH RELEVANCE: Real-time tumor tracking in radiation therapy, with positional accuracies less than 1 mm, will guide radiation to the exact location. This will reduce complications and increase tumor control to the extent that has not been possible with existing technologies.

描述(申请人提供)：放射治疗的目标是向肿瘤提供治疗剂量的辐射，同时将对周围正常组织的损害降至最低。目前，肿瘤定位是实现根治性放射剂量的放射治疗中最重要的问题。为了最大限度地增加给药剂量，在治疗过程中，必须在空间和时间上都准确地知道肿瘤的位置，以击中运动重要的靶点。为了考虑这种位置的不确定性，在治疗期间，肿瘤剂量被输送到肿瘤可能所在的体积。因此，随着定位的不确定，治疗量和相应的并发症增加。该项目的长期目标是在放射治疗期间准确定位肿瘤的实时位置，并满足以下限制条件，以加强对肿瘤的控制：(1)通过实时跟踪对肿瘤进行定位，并在一秒内获得位置更新；(2)通过相对于治疗室内定义的坐标系以低于1毫米的精度描述肿瘤位置；(3)探测器将扩展到2-3米或更大的范围。该项目提出的定位系统由(1)植入式无源发射机、(2)为发射机供电的外部偶极子天线和(3)超导量子干涉装置(SQUID)磁强计探测系统组成。通电的发射机将产生一个脉冲磁场，该磁场将被SQUID传感器探测到，然后用于实时定位发射机的位置。该项目的第一阶段工作将专门针对探测器系统的设计。目标是构建一个矢量磁力计系统，该系统将在0.1PT的水平上测量磁场信号。为了探测到这些极低水平的信号，将使用SQUID磁强计作为传感器。尽管它们的灵敏度很高，但噪声是一个主要问题，需要特定的滤波和设计才能检测到这些信号。我们将通过在该项目中进行的测量和实验来设计基本系统。与公共卫生相关：放射治疗中的实时肿瘤跟踪，其定位精度低于1毫米，将引导放射治疗到准确的位置。这将减少并发症，并将肿瘤控制提高到现有技术所不可能达到的程度。