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MEMS Blood Pressure Sensor for a Pediatric VAD

用于儿科 VAD 的 MEMS 血压传感器

基本信息

批准号：
7269163
负责人：
BRIAN NORLING
金额：
$ 22.31万
依托单位：
LAUNCHPOINT TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7269163
关键词：
Abdomen Address Adult Algorithms Amplifiers Aneurysm Animals Back Biological Models Blood Blood Pressure Blood Pressure Monitors Blood flow Calibration Cardiac Cardiac Surgery procedures Cardiomyopathies Cardiovascular system Catheters Childhood Clinical Code Coin Computer software Coupled Coupling Custom Data Decompression Sickness Detection Devices Diastolic blood pressure Digital Signal Processing Electromagnetics Electronics Equilibrium Evaluation Failure Feedback Finite Element Analysis Flushing Frequencies Government Housing In Vitro Infant Laboratories Lead Left Magnetism Marketing Measurement Measures Methods Modeling Molds Monitor Motion Noise Numbers Object Attachment Operative Surgical Procedures Paper Patients Perioperative Persons Phase Physiologic pulse Principal Investigator Process Pulmonary artery structure Pulse taking Pump Purpose Rate Respiratory Diaphragm Shapes Signal Transduction Silicon Simulate Software Design Stents Structure System Technology Testing Time Titanium Transplantation Universities Upper arm Urethane Vacuum Validation Ventricular analog computerized data processing concept congenital heart disorder cost design digital dipole moment electric impedance improved in vivo innovation magnetic field mortality motor control new technology pressure repaired response seal sensor simulation size ventricular assist device

项目摘要

DESCRIPTION (provided by applicant): Approximately 30,000 new cases of congenital heart disease (CHD) occur each year with an annual mortality rate of 5,000 to 6,000 patients. At least 20% of these patients die due to perioperative ventricular failure, progressive cardiomyopathy (CM) or complications following cardiac transplants. Of those, 1,000 to 1,200 pediatric patients per year represent the candidates for our PediaFlowTM Ventricular Assist Device (PVAD). This project aims to enable end-diastolic pressure control for the PediaFlowTM by developing a miniature pressure sensor to be embedded in the pump inflow wall. This pressure sensor incorporates a number of innovations including: a dynamically-balanced silicon resonator, connector-less assembly through the use of a permanent magnet coupling concept, and a pulsed approach to excitation and signal processing. These innovations will lead to a low-cost hermetically-sealed 2mm-scale pressure sensor which meets the above need as well as being applicable to cardiac catheterized patients and other surgical candidates. MEMS Blood Pressure Sensor for a Pediatric VAD Principal Investigator: Brink, Damon Project Narrative The measurement of blood pressure is critical to the ongoing treatment of many circulatory ailments. Any of the thousands of cardiac surgery patients, in particular patients utilizing ventricular assist devices (VADs), especially infants, require nearly constant monitoring. This project applies new electromechanical systems (MEMS) technology to enable software algorithms and clinicians to easily track fluctuations in blood pressure.

描述(申请人提供)：每年新增先天性心脏病(CHD)病例约30,000例，每年死亡率为5,000至6,000人。这些患者中至少有20%死于围手术期心力衰竭、进行性心肌病(CM)或心脏移植后的并发症。在这些患者中，每年有1,000至1,200名儿科患者代表我们的PediaFlowTM脑室辅助装置(PVAD)的候选患者。该项目旨在通过开发嵌入泵流入壁的微型压力传感器来实现PediaFlowTM的舒张末压力控制。这种压力传感器结合了许多创新，包括：动态平衡硅谐振器、通过使用永磁体耦合概念的无连接器组装以及脉冲激励和信号处理方法。这些创新将导致一种低成本的密封2 mm尺度的压力传感器，该传感器满足上述需求，并适用于心导管术患者和其他外科候选人。MEMS血压传感器用于儿科VAD首席研究员：Brink，Damon项目叙述血压测量对正在进行的许多循环系统疾病的治疗至关重要。数以千计的心脏手术患者，特别是使用心脏辅助装置(VAD)的患者，特别是婴儿，几乎需要持续监测。该项目应用了新的机电系统(MEMS)技术，使软件算法和临床医生能够轻松跟踪血压波动。