ALERTNESS AND COGNITIVE PERFORMANCE IN SLEEP-RESTRICTED

睡眠受限时的警觉性和认知表现

• 批准号: 7084875
• 负责人: Jeanne F Duffy
• 金额: $ 13.71万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7084875
• 关键词: actigraphy; age difference; aging; attention; circadian rhythms; cognition; eye movements; human middle age (35-64); human old age (65+); performance; personal log /diary; polysomnography; short term memory; sleep; sleep deprivation; sleep disorders; wakefulness; young adult human (21-34)

Insufficient sleep is a major health and safety problem for young and older adults alike. National polls indicate that more than a quarter of adults 18-84 years of age regularly sleep less than 7 h per night, with 15% reporting sleeping less than 6 h per night. The deficits in alertness and performance ability associated with insufficient sleep can lead to greater risk for automobile accidents, home and workplace accidents, and on-the-job errors in sleepy individuals. Insufficient sleep can also have a negative effect on the quality of life, with impacts on irritability, mood, and motivation. There is evidence from acute sleep deprivation studies that older adults may respond differently to sleep loss than young adults, but studies comparing the response to chronic sleep restriction in older and young adults have not yet been conducted. Here, we propose to investigate the consequences of 4 weeks of chronic insufficient sleep on daytime alertness and performance in older (55-70) and young (18-30) adults. Subjects will be scheduled to sleep an equivalent of 5 h per 24 h in a forced desynchrony protocol, in order that we can investigate both the circadian and wake-dependent contributions to alertness and performance across the 4 weeks of sleep restriction. We will use subjective and objective measures to assess alertness across each waking episode, and subjects will perform a battery of tasks several times per day to measure the consequences of sleep restriction on cognitive throughput, sustained attention, reaction time, motivation, mood and short-term memory. Our study design will allow us to assess independently the impact of time-of-day (circadian phase) and duration of prior wakefulness, as well as their interactions, on measures of daytime alertness and performance under conditions of sleep restriction across 4 weeks. Results from this study have important implications for understanding the consequences of chronic insufficient sleep in older adults. Most adults regularly fail to get sufficient sleep, but few studies have attempted to quantify the consequences of chronic insufficient sleep in middle-aged and older people. Insufficient sleep can have important effects on health, safety, and quality of life. Knowledge of how the alertness, performance, and memory of healthy older people respond to insufficient sleep will provide a basis for future research and for advice and recommendations for maintaining health and well-being as we age.

对于年轻人和老年人来说，睡眠不足是一个重大的健康和安全问题。国家民意测验 表明超过四分之一的18-84岁的成年人定期睡眠不到每晚7小时， 15％的报告每晚睡觉不到6小时。机敏性和性能能力相关的缺陷 由于睡眠不足会导致汽车事故，家庭和工作场所事故的更大风险，以及 困倦的人在职错误。睡眠不足也会对生活质量产生负面影响， 对烦躁，情绪和动力产生影响。急性睡眠剥夺研究有证据表明 老年人对睡眠损失的反应可能与年轻人不同，但是将反应与 尚未进行年龄段和年轻人的慢性睡眠限制。 在这里，我们建议研究白天长期睡眠不足4周的后果 年龄较大（55-70）和年轻人（18-30）成年人的警觉性和表现。受试者将安排睡觉 在强制性取消协议中，相当于每24小时5小时，以便我们可以研究 在4周的睡眠中，昼夜节律和依赖尾流的贡献 限制。我们将采取主观和客观措施来评估每个醒着情节的警觉性， 主题每天将几次执行一系列任务以衡量睡眠的后果 限制认知吞吐量，持续关注，反应时间，动机，情绪和短期 记忆。我们的研究设计将使我们能够独立评估一天的时间（昼夜节律）的影响 以及先前的清醒及其互动的持续时间，白天警报的措施和 在4周内睡眠限制条件下的表现。 这项研究的结果对理解慢性的后果具有重要意义 老年人睡眠不足。大多数成年人经常无法获得足够的睡眠，但是很少有研究 试图量化中年和老年人长期睡眠不足的后果。 睡眠不足会对健康，安全和生活质量产生重要影响。了解如何 机敏性，表现和对健康老年人的记忆对睡眠不足的反应将提供基础 为了将来的研究以及随着年龄的增长而保持健康和福祉的建议和建议。