Psychosocial and Neighborhood Mechanisms and Consequences of Black-White Sleep Disparties on Cognition

心理社会和邻里机制以及黑白睡眠差异对认知的影响

• 批准号: 10868330
• 负责人: Alyssa Ann Gamaldo
• 金额: $ 39.76万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10868330
• 关键词: Address; Administrative Supplement; Adult; African American; Alzheimer' s Disease; Alzheimer' s disease related dementia; Award; Biological Markers; Black Populations; Black race; COVID-19 pandemic; COVID-19 pandemic effects; Cognition; Cognitive; Cognitive Therapy; Communities; Complex; Coupling; Data; Data Collection; Devices; Disease; Disparity; Educational Intervention; Evaluation; Event; Evidence based intervention; Exposure to; Financial Hardship; Funding; Future; Goals; Health; Health Disparities Research; Human Resources; Impaired cognition; Impairment; Individual; Inflammation; Inflammatory; Interleukin-10; Interleukin-6; Intervention; Knowledge; Life; Life Cycle Stages; Literature; Longevity; Measures; Methods; Mission; Monitor; Neighborhoods; Neuropsychological Tests; Parents; Participant; Performance; Population; Procedures; Protocols documentation; Psychometrics; Psychosocial Assessment and Care; Psychosocial Factor; Public Health; Race; Research; Risk; Role; Sampling; Sleep; Sleep disturbances; Spirituality; Testing; Underrepresented Populations; Underserved Population; United States National Institutes of Health; Variant; Videoconferencing; Work; actigraphy; biopsychosocial; black/white disparity; cognitive function; cognitive testing; cognitive training; cohesion; community based participatory research; contextual factors; coping; data reduction; dementia risk; design; experience; health difference; health disparity; healthy aging; high risk; improvement on sleep; inflammatory marker; innovation; insight; intervention program; middle age; mild cognitive impairment; pandemic disease; parent project; protective factors; psychosocial; racial difference; racial disparity; racial diversity; recruit; resilience factor; retention rate; sleep health; smartphone based assessment; social; social disparities; socioeconomics; stressor; success; time interval; wireless; wireless fidelity

FUNDED PARENT UF1 SUMMARY African American/Black adults are at an elevated risk for mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD)1–3.Thus, the identification of modifiable factors underlying this heightened risk is urgently needed. One such modifiable factor essential to cognitive health is sleep. Specifically, sleep is associated with impaired cognitive functioning and risk for mild cognitive impairment, particularly within Black adults4–6. Additionally, life stressors and protective/resilient factors are associated with cognitive and sleep health7–12, but limited research has revealed how all these factors interconnect to explain observable differences in cognitive functioning within Black adults. Understanding these associations is even more pressing in midlife – a period of life (a) where the sleep-cognition relationship has not been extensively investigated, (b) for which Black people are at a high risk of cognitive dysfunction, and (c) represents an ideal period to target for intervention13. The overall objective of this study, branded Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Sleep, is to identify mechanisms of Black-White sleep disparities and the mechanisms that account for Black-White differences in ADRD risk. The study includes annual assessments across 3 years to assess sleep duration and quality, cognitive functioning, inflammatory biomarkers (e.g., CRP, IL-6), life stressors (e.g., perceived neighborhood disorder), and resilience factors (e.g., spirituality, coping) in a sample of middle-aged (30-64 years) Black and White participants from the HANDLS Study. The HANDLS Sleep Study includes three specific aims: Aim 1: determine if there are racial differences in the daily coupling of sleep and mobile cognitive functioning and whether differences in this coupling are moderated by life stressors (e.g., financial strain and neighborhood disorder); Aim 2: test longitudinal associations among sleep and performance on mobile cognitive assessments and explore the role of life stressors, protective factors (e.g., spirituality and neighborhood cohesion) and inflammation; Aim 3: determine whether changes in the strength of the daily coupling of sleep and performance on mobile cognitive assessments relate to racial differences in traditional annual measures of cognitive decline over 3 years, and to elucidate the potential mediational role of inflammation. The HANDLS Sleep Study is innovative because it will examine the association between sleep and cognitive functioning over various time intervals (daily and annual), and it will also examine the relationship of life stressors, sleep, inflammatory biomarkers, and/or resilient factors on racial disparities in cognitive decline. Furthermore, this research is significant because of its potential to identify psychosocial and contextual factors related to impaired sleep and cognition that could serve as the basis for evidence-based interventions.

供资方案UF 1汇总 非裔美国人/黑人成年人患轻度认知障碍（MCI）和阿尔茨海默病的风险较高 疾病和相关痴呆（ADRD）1- 3。因此， 迫切需要提高风险。其中一个对认知健康至关重要的可变因素是睡眠。 具体来说，睡眠与认知功能受损和轻度认知障碍的风险有关， 特别是在黑人成人中4 -6。此外，生活压力源和保护/弹性因素与以下因素有关： 认知和睡眠健康7 -12，但有限的研究揭示了所有这些因素如何相互联系，以解释 黑人成年人认知功能的明显差异。了解这些联系， 更紧迫的是在中年-一个时期的生活（a）睡眠认知关系还没有广泛 调查，（B）黑人处于认知功能障碍的高风险中，（c）代表理想的 达到干预目标的时间13.这项研究的总体目标是， 的多样性跨越生命跨度（手）睡眠，是确定机制的黑白睡眠差异 以及ADRD风险中黑白差异的机制。该研究包括年度 3年内评估睡眠持续时间和质量、认知功能、炎症 生物标记（例如，CRP、IL-6）、生活应激源（例如，感知的邻里紊乱），和弹性因素（例如， 精神，应对）在中年（30-64岁）黑人和白色参与者的样本从手 Study. HANDLS睡眠研究包括三个具体目标：目标1：确定是否存在种族差异 睡眠和移动的认知功能的日常耦合，以及这种耦合的差异是否 由生活压力调节（例如，金融紧张和邻里无序）;目标2：纵向检验 睡眠与移动的认知评估表现之间的关联，并探索生活的作用 应激源，保护因素（例如，灵性和邻里凝聚力）和炎症;目标3： 确定睡眠和移动的认知性能的日常耦合强度的变化是否 评估涉及3年内认知能力下降的传统年度测量中的种族差异，以及 阐明炎症的潜在介导作用。HANDLS睡眠研究是创新的，因为它 将研究睡眠和认知功能之间的关联在不同的时间间隔（每天和 每年），它还将检查生活压力源，睡眠，炎症生物标志物和/或 认知能力下降的种族差异的弹性因素。此外，这项研究具有重要意义，因为它 有可能识别与睡眠和认知受损相关的心理社会和背景因素， 作为循证干预措施的基础。

项目成果

The promotion of sleep wellness: Resilience as a protective factor.

促进睡眠健康：弹性作为保护因素。

• DOI: 10.3389/frsle.2023.1133347
• 发表时间: 2023
• 期刊: Frontiers in sleep
• 作者: Allan,AlexaC;Gamaldo,AlyssaA;Gamaldo,CharleneE;Gunia,BrianC;Razzak,IyiadMohamedAlAbdul;Ighodaro,Edoghogho;Salas,RachelMarieE
• 通讯作者: Salas,RachelMarieE