Experimental Genetics of the Laboratory Mouse in Cancer Research

描述（由申请人提供）：癌症是一组遗传复杂且生物学异质性的疾病。越来越清楚的是，实验室小鼠是人类基因定义最好的实验模式生物，为快速了解癌症的遗传基础提供了重要机会。因此，在小鼠遗传学、基因组学和生物学方面进行基础广泛的培训的工具对实现这一目标至关重要。我们课程的总体目标是培训年轻科学家（博士前，博士后学员，新的研究人员），并重新培训已建立的研究人员使用遗传定义的实验室小鼠作为遗传工具，询问有关基因功能和遗传学在癌症中的作用的问题。完成课程的学生将获得以下工作知识：（1）小鼠遗传学和基因组学，（2）生长控制和癌症，（3）实验设计和统计遗传学在复杂性状分析中的应用，（4）生物信息学，（5）与小鼠一起工作的动物健康和伦理考虑，（6）基本的小鼠手术技术，（7）体内成像和（8）人类癌症的小鼠模型。将重点介绍小鼠如何用于基础研究向临床的转化。 这些目标将通过提供一个密集的10天的课程，以30名学生选择他们的杰出的研究潜力来实现。他们将与一群来自杰克逊实验室和其他机构的著名小鼠遗传学家和生物学家互动。学生入学人数故意保持较小，以实现学生与教师互动的理想水平。该课程将于每年8月的最后两周在公海举行，杰克逊实验室的海滨会议中心是课程演示和学生和教师住宿的地点。上午、下午和晚上举行讲座、讨论、研讨会和演示，总共约80小时的教学和实践培训。 杰克逊实验室是美国国家癌症研究所指定的癌症中心，在举办高级课程和科学会议方面有着悠久的历史。本申请中所述的“癌症研究中实验小鼠的实验遗传学”课程自1992年以来每年举办一次。 与人类健康的相关性：实验室小鼠是一种强大的遗传工具，将继续在理解癌症的遗传基础以及预测新的和现有疗法的临床安全性和有效性方面发挥深远的作用。像这样的短期课程是培养治愈这种疾病所需的高技能年轻研究人员骨干所必需的。

DESCRIPTION (provided by applicant): Cancer is a genetically complex and biologically heterogeneous group of disorders. It has become increasingly clear that the laboratory mouse, the best genetically defined experimental model organism for humans, presents a major opportunity for rapid advancement in understanding the genetic basis of cancer. Therefore, tools for broad-based training in mouse genetics, genomics and biology is critical to meet this end. The overall goal for our course is to train young scientists (predoctoral, postdoctoral trainees, new investigators) and to re-train established investigators in the use of genetically defined laboratory mice as genetic tools for asking questions about gene function and the role of genetics in cancer. Students completing the course will acquire a working knowledge of: (1) mouse genetics and genomics, (2) growth control and cancer, (3) experimental design and the application of statistical genetics to complex trait analysis, (4) bioinformatics, (5) animal health and ethical considerations in working with mice, (6) basic mouse surgical techniques, (7) in vivo imaging and (8) mouse models for human cancer. How the mouse is used in the translation of basic research to the clinic will be emphasized. These Aims will be accomplished by offering an intensive 10-day course to 30 students chosen for their outstanding research potential. They will interact with a group of prominent mouse geneticists and biologists both from The Jackson Laboratory and other institutions. Student enrollment is kept deliberately small to achieve the desired level of student-faculty interaction. The course will be held annually during the last 2 weeks of August in a retreat setting at Highseas, The Jackson Laboratory's oceanfront conference center that is the site both for the course presentations and residential accommodations for the students and faculty. Lectures, discussions, workshops, and demonstrations are held mornings, afternoons, and evenings for a total of approximately 80 hours of didactic and hands-on training. The Jackson Laboratory is an NCI-designated Cancer Center and has a long history of hosting advanced courses and scientific meetings. The course on "Experimental Genetics of the Laboratory Mouse in Cancer Research" described in this application has been held annually since 1992. Relevance to Human Health: The laboratory mouse is a powerful genetic tool that will continue to play a profound role in understanding the genetic basis of cancer, and in predicting clinical safety and efficacy of new and existing therapies. Short courses such as these are required to develop the cadre of highly skilled young investigators that will be needed to cure this disease.