Neurobiology & Genetics Laboratory Core

神经生物学和遗传学实验室核心(NGLC)将对多个 从而确保各项目之间的最佳和可比较的可靠性。它提供了规模经济 并随着学习优先顺序的改变而转移资源。这些检测分为几个主要领域。毒理学 使用脑组织的分析提供了最近精神药物暴露的较长时间框架 药物比体液高，因为大脑水平往往高出10-40倍。这将对 项目1中的死后大脑研究，药物可能会改变结果。第二个领域是遗传学和 表观遗传学。这里的分析将包括基因变异、甲基化和基因表达分析。后者 DOMAIN适用于项目1和项目2。核心将检测项目5中的唾液皮质醇和响应 也将与项目3和4的结果相关联。由于项目6正在研究自杀行为如何 可能是由项目3和4的大型成像数据集预测的，它还将考虑 来自项目5的实验室数据。因此，来自该核心的研究结果与每个项目直接或间接相关。

The Neurobiology and Genetics Laboratory Core (NGLC) will carry out specialized assays for multiple projects and thereby insure optimal and comparable reliability across projects. It offers an economy of scale and moves resources as study priorities change. The assays fall into several major domains. Toxicology assays such as ones using brain tissue provide a longer time frame on most recent exposure to psychotropic drugs than body fluids since brain levels tend to be 10-40 times higher. This will be valuable for the postmortem brain studies in Project 1 where drugs may alter the results. The second domain is genetics and epigenetics. Here assays will include gene variants, methylation and gene expression assays. The latter domain is applicable to Projects 1 and 2. The core will assay salivary Cortisol in Project 5 and the responses will also be correlated with findings from Projects 3 and 4. Since Project 6 is looking at how suicidal behavior may be predicted by the large imaging data sets from Projects 3 and 4, it will also consider the impact of the laboratory data from Project 5. Thus, findings from this core are relevant directly or indirectly to every project.