GAMMACELL-220 EXCEL REFURBISHED RESEARCH IRRADIATOR: BIODEFENSE

GAMMACELL-220 EXCEL 翻新研究辐照器：生物防御

• 批准号: 7335187
• 负责人: DAVID H WALKER
• 金额: $ 10.64万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7335187
• 关键词: biomedical facility; bioterrorism /chemical warfare; communicable diseases; community; hyperthermia; infection; proteomics; success; university

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Over the past two decades, the University of Texas Medical Branch at Galveston (UTMB) has built a premier infectious disease research program focused on emerging infections and biodefense pathogens in accordance with the NIAID's mission to develop countermeasures for these agents. This success is largely due to a critical mass of world-class researchers and the availability of unique laboratory facilities. In 2003, UTMB was the only academic institution awarded NIAID grants to establish both a Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research and a National Biocontainment Laboratory (NBL) to provide more high containment laboratory space. In addition, with partial support from the NIAID, a toiosafety level 4 (BSL4) laboratory was opened in 2003 (and became operational in 2004) as the first laboratory of its type on a university campus in North America. These facilities provide an opportunity to increase overall research efforts, including the capability to conduct studies on the world's most dangerous pathogens. A critical requirement inherent to the scope of the NIAID's research mission is to share these facilities with regional and national researchers and to provide support services for research that can only be done in these high containment facilities. A reliable biosafety and biosecurity method is essential for sharing and working safely with the highly dangerous agents. Therefore, the overall objective is to procure a Gammacell 220 Excel refurbished research irradiator to provide the most reproducible and controlled method to inactivate these dangerous agents while at the same time preserving their biological properties. An example of use of this instrument will be to inactivate Rift Valley fever virus such that genomic and proteomics analysis can be safely performed outside the BSL4 laboratory. The irradiator will be available for use by NIH-supported UTMB investigators, as well as NIH-supported regional and national investigators. When the NBL is completed in 2008, researchers from that facility will also have access to the irradiator. A representative users' group with 21 funded grants are described, including 14 major (12 of which are NIH- funded) and 7 minor users representing multidisciplinary research projects involving several departments at UTMB. It is important to note that usage of the proposed gamma irradiator will drastically increase as usage of the BSL4 laboratory increases and with the completion of the NBL. The irradiator will be maintained and operated under an advisory oversight committee as a core facility in the Center for Biodefense and Emerging Infectious Diseases at UTMB. Yearly maintenance fees will be charged to Pis and administered through the BSL4 Service Center. The irradiator will significantly enhance the ability of investigators to conduct research safely and more efficiently, as well as protect the community from any threats that may be associated with working with these life-threatening pathogens.

该子项目是利用 NIH/NCRR 资助的共享仪器补助金提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是资助机构，不一定是研究者的机构。描述（由申请人提供）：在过去的二十年中，德克萨斯大学加尔维斯顿医学分部 (UTMB) 根据 NIAID 为这些病原体制定对策的使命，建立了一个主要的传染病研究项目，重点关注新出现的感染和生物防御病原体。这一成功很大程度上归功于大量的世界一流研究人员和独特的实验室设施。 2003 年，UTMB 是唯一一家获得 NIAID 拨款的学术机构，用于建立生物防御和新兴传染病研究区域卓越中心和国家生物防护实验室 (NBL)，以提供更高安全性的实验室空间。此外，在 NIAID 的部分支持下，2003 年开设了一个 4 级安全 (BSL4) 实验室（并于 2004 年投入运营），这是北美大学校园中第一个此类实验室。这些设施为加强整体研究工作提供了机会，包括对世界上最危险的病原体进行研究的能力。 NIAID 研究任务范围固有的一个关键要求是与地区和国家研究人员共享这些设施，并为只能在这些高密闭设施中进行的研究提供支持服务。可靠的生物安全和生物安保方法对于安全地共享和使用高度危险的制剂至关重要。因此，总体目标是采购 Gammacell 220 Excel 翻新研究辐照器，以提供最具重复性和可控性的方法来灭活这些危险物质，同时保留其生物特性。使用该仪器的一个例子是灭活裂谷热病毒，以便可以在 BSL4 实验室外安全地进行基因组和蛋白质组学分析。该辐照器可供 NIH 支持的 UTMB 研究人员以及 NIH 支持的地区和国家研究人员使用。当 NBL 于 2008 年竣工时，该设施的研究人员也将能够使用辐照器。描述了具有 21 项资助的代表性用户组，其中包括 14 个主要用户（其中​​ 12 个由 NIH 资助）和 7 个次要用户，代表涉及 UTMB 多个部门的多学科研究项目。值得注意的是，随着 BSL4 实验室使用量的增加以及 NBL 的完成，所提议的伽马辐照器的使用量将急剧增加。该辐照器将作为 UTMB 生物防御和新发传染病中心的核心设施，在咨询监督委员会的监督下进行维护和运营。每年的维护费将向 Pi 收取并通过 BSL4 服务中心进行管理。该辐照器将显着增强研究人员安全、更有效地进行研究的能力，并保护社区免受与这些危及生命的病原体相关的任何威胁。