Gammacell-220 Excel Refurbished Research Irradiator

Gammacell-220 Excel 翻新研究辐照器

• 批准号: 7046980
• 负责人: DAVID H WALKER
• 金额: $ 35.48万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7046980
• 关键词: biomedical facility; bioterrorism /chemical warfare; communicable diseases; community; hyperthermia; infection; proteomics; success; university

DESCRIPTION (provided by applicant): Over the past two decades, the University of Texas Medical Branch at Galveston (UTMB) has built a premier infectious disease research program focused on emerging infections and biodefense pathogens in accordance with the NIAID's mission to develop countermeasures for these agents. This success is largely due to a critical mass of world-class researchers and the availability of unique laboratory facilities. In 2003, UTMB was the only academic institution awarded NIAID grants to establish both a Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research and a National Biocontainment Laboratory (NBL) to provide more high containment laboratory space. In addition, with partial support from the NIAID, a toiosafety level 4 (BSL4) laboratory was opened in 2003 (and became operational in 2004) as the first laboratory of its type on a university campus in North America. These facilities provide an opportunity to increase overall research efforts, including the capability to conduct studies on the world's most dangerous pathogens. A critical requirement inherent to the scope of the NIAID's research mission is to share these facilities with regional and national researchers and to provide support services for research that can only be done in these high containment facilities. A reliable biosafety and biosecurity method is essential for sharing and working safely with the highly dangerous agents. Therefore, the overall objective is to procure a Gammacell 220 Excel refurbished research irradiator to provide the most reproducible and controlled method to inactivate these dangerous agents while at the same time preserving their biological properties. An example of use of this instrument will be to inactivate Rift Valley fever virus such that genomic and proteomics analysis can be safely performed outside the BSL4 laboratory. The irradiator will be available for use by NIH-supported UTMB investigators, as well as NIH-supported regional and national investigators. When the NBL is completed in 2008, researchers from that facility will also have access to the irradiator. A representative users' group with 21 funded grants are described, including 14 major (12 of which are NIH- funded) and 7 minor users representing multidisciplinary research projects involving several departments at UTMB. It is important to note that usage of the proposed gamma irradiator will drastically increase as usage of the BSL4 laboratory increases and with the completion of the NBL. The irradiator will be maintained and operated under an advisory oversight committee as a core facility in the Center for Biodefense and Emerging Infectious Diseases at UTMB. Yearly maintenance fees will be charged to Pis and administered through the BSL4 Service Center. The irradiator will significantly enhance the ability of investigators to conduct research safely and more efficiently, as well as protect the community from any threats that may be associated with working with these life-threatening pathogens.

描述（由申请人提供）：在过去的二十年中，德克萨斯大学医学分支在加尔维斯顿（UTMB）已经建立了一个首要的传染病研究计划，重点是新出现的感染和生物防御病原体按照NIAID的使命，以制定这些代理商的对策。这一成功在很大程度上归功于世界级研究人员的临界质量和独特的实验室设施的可用性。2003年，UTMB是唯一一家获得NIAID赠款的学术机构，建立了生物防御和新兴传染病研究区域卓越中心和国家生物遏制实验室（NBL），以提供更多的高遏制实验室空间。此外，在NIAID的部分支持下，2003年开设了一个厕所安全4级（BSL 4）实验室（并于2004年投入使用），这是北美大学校园内第一个此类实验室。这些设施为加强总体研究工作提供了机会，包括对世界上最危险的病原体进行研究的能力。NIAID研究使命范围所固有的一个关键要求是与区域和国家研究人员共享这些设施，并为只能在这些高封闭设施中进行的研究提供支助服务。可靠的生物安全和生物安保方法对于分享高度危险物剂和安全地使用高度危险物剂至关重要。因此，总体目标是采购Gammacell 220 Excel翻新研究辐照器，以提供最可重复和最可控的方法来消除这些危险制剂，同时保持其生物特性。使用该仪器的一个例子是对裂谷热病毒进行测序，以便在BSL 4实验室之外安全地进行基因组学和蛋白质组学分析。该辐照器将可供NIH支持的UTMB研究人员以及NIH支持的地区和国家研究人员使用。当NBL在2008年完成时，该设施的研究人员也将可以使用辐照器。一个有代表性的用户组与21个资助的赠款，包括14个主要（其中12个是NIH资助）和7个小用户代表多学科研究项目，涉及几个部门在UTMB。重要的是要注意，随着BSL 4实验室使用量的增加和NBL的完成，拟议伽马辐照器的使用量将急剧增加。辐照器将在咨询监督委员会的监督下维护和运行，作为UTMB生物防御和新发传染病中心的核心设施。每年的维护费用将由Pis支付，并通过BSL 4服务中心进行管理。辐照器将大大提高研究人员安全和更有效地进行研究的能力，并保护社区免受与这些危及生命的病原体有关的任何威胁。